EIF4A2 - eukaryotic translation initiation factor 4A2 Gene

Also Known as DDX2B; EIF4A; EIF4F; BM-010; eIF4A-II; eIF-4A-II

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1974

About EIF4A2

Cytogenetic location: 3q27.3 Genomic coordinates (GRCh38): 3:186,783,577-186,789,897 (from NCBI)

This gene has 27 transcripts (splice variants), 230 orthologues, 38 paralogues and is associated with 54 phenotypes. Ubiquitous expression in ovary (RPKM 426.9), brain (RPKM 313.7) and 25 other tissues.

Summary

Enables ATP hydrolysis activity. Involved in negative regulation of RNA-directed 5'-3' RNA polymerase activity. Located in perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

EIF4A2 Products (1)

mRNA Protein Name
NM_001967.4 NP_001958.2 eukaryotic initiation factor 4A-II

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP hydrolysis activity IDA
IDA: Inferred from direct assay
11922617 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11922617 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of RNA-dependent RNA polymerase activity IDA
IDA: Inferred from direct assay
11922617 GOA
Cellular Component GO Annotation Evidence References Source
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
11922617 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF4A2 Protein Structure

DEAD

DEAD: DEAD/DEAH box helicase (59 - 224)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (294 - 369)

  • 0
  • 100
  • 200
  • 300
  • 408 a.a.
Protein Preferred Names Protein Names

eukaryotic initiation factor 4A-II

  • ATP-dependent RNA helicase eIF4A-2

EIF4A2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
EIF4A2 Q14240 SLC16A9 Homo sapiens Q7RTY1
Validated Y2H
25416956
Intra
EIF4A2 Q14240 SLC16A9 Homo sapiens Q7RTY1
Y2H Prey Pooling
25416956
Intra
EIF4A2 Q14240 SSX2IP Homo sapiens Q9Y2D8
Y2H Prey Pooling
25416956
Intra
EIF4A2 Q14240 TRIM36 Homo sapiens Q9NQ86
Y2H Array
25416956
Intra
EIF4A2 Q14240 TRIM36 Homo sapiens Q9NQ86
Validated Y2H
25416956
Intra
EIF4A2 Q14240 HSPB1 Homo sapiens P04792
Anti Bait CoIP
25277244
Intra
EIF4A2 Q14240 HSPB1 Homo sapiens P04792
Reverse RRS
25277244
Intra
EIF4A2 Q14240 DPPA4 Homo sapiens Q7L190
Y2H Array
25416956
Intra
EIF4A2 Q14240 TRIM39 Homo sapiens Q9HCM9
Y2H Array
31515488
Intra
EIF4A2 Q14240 TRIM39 Homo sapiens Q9HCM9
Y2H Array
25416956
Intra
EIF4A2 Q14240 IPO11 Homo sapiens Q9UI26
Y2H Prey Pooling
25416956
Intra
EIF4A2 Q14240 PDCD4 Homo sapiens Q53EL6
Y2H Prey Pooling
25416956
Intra
EIF4A2 Q14240 PDCD4 Homo sapiens Q53EL6
Y2H Array
25416956
Cross
EIF4A2 Q14240 P27958-PRO_0000037577 Hepatitis C virus P27958-PRO_0000037577
Y2H
11922617
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EIF4A2 Proteins

Cat. No. Product Name Accession Purity
HY-P700526 EIF4A2 Protein, Human (GST) Q14240 (M1-I407) ≥ 90%, as determined by reducing SDS-PAGE.

EIF4A2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P87157 eIF4A2 Antibody (YA6850) WB, IHC-P, ICC/IF, FC Human, Mouse, Rat, Monkey

Related Diseases

Diseases Alias
Fragile X-Associated Tremor/Ataxia Syndrome

  • Fxtas Syndrome

  • Fragile X Tremor/Ataxia Syndrome

  • Fxtas
Spinocerebellar Ataxia 8

  • Spinocerebellar Ataxia Type 8

  • SCA8

  • Ataxia, Spinocerebellar, Type 8
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-145262 eIF4E-IN-2 Inhibitor 98.91% Unkown
HY-129768 CMLD012072 Inhibitor / Unkown
HY-176843 eIF4A-IN-2 Inhibitor / Unkown
HY-RS04271 EIF4A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04275 EIF4E2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04278 EIF4EBP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04282 EIF4G2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17097 Eif4b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20664 Eif4ebp2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21121 Eif4a2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27175 Eif4ebp2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27640 Eif4a2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta EIF4A2 VGNC VGNC:84185
Canis familiaris EIF4A2 VGNC VGNC:40280
Mus musculus EIF4A2 MGD MGI:106906
Bos taurus EIF4A2 VGNC VGNC:28405
Felis catus EIF4A2 VGNC VGNC:61788
Rattus norvegicus EIF4A2 RGD RGD:1309225
Others EIF4A2 NCBI