SLC51A - solute carrier family 51 member A Gene

Also Known as OSTA; PFIC6; SLC51A1; OSTalpha

Species: Homo sapiens (human)

Gene Type: protein coding
Gene ID: 200931

Summary

Predicted to enable protein heterodimerization activity; protein homodimerization activity; and transmembrane transporter activity. Involved in bile acid secretion. Located in basolateral plasma membrane. Implicated in progressive familial intrahepatic cholestasis. [provided by Alliance of Genome Resources, Apr 2022]

SLC51A Products (1)

mRNA Protein Name
NM_152672.6 NP_689885.4 organic solute transporter subunit alpha

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16713569 GOA
Biological Process GO Annotation Evidence References Source
involved in bile acid secretion IPI
IPI: Inferred from physical interaction
16317684 GOA
Cellular Component GO Annotation Evidence References Source
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
16317684 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
12719432 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

organic solute transporter subunit alpha

  • OST-alpha

  • organic solute transporter alpha

  • organic solute transporter, alpha subunit

  • solute carrier family 51 alpha subunit

  • solute carrier family 51 subunit alpha

SLC51A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SLC51A Q86UW1 DNAJC30 Homo sapiens Q96LL9
Validated Y2H
32296183
Intra
SLC51A Q86UW1 ATXN1 Homo sapiens P54253
Y2H Array
16713569
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13280 SLC5A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13281 Slc5a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13276 SLC51B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13282 Slc5a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SLC51A VGNC VGNC:34900
Rattus norvegicus SLC51A RGD RGD:1311100
Canis familiaris SLC51A VGNC VGNC:46440
Mus musculus SLC51A MGD MGI:2146634
Felis catus SLC51A VGNC VGNC:65395
Macaca mulatta SLC51A VGNC VGNC:77793
Others SLC51A NCBI