Sstr3 - somatostatin receptor 3 Gene

Also Known as sst3; Smstr3; Smstr-3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20607

About Sstr3

Chromosome 15: 78,421,208-78,428,885 reverse strand.GRCm39:CM001008.3

This gene has 2 transcripts (splice variants), 251 orthologues and 15 paralogues. Biased expression in frontal lobe adult (RPKM 2.7), cortex adult (RPKM 2.1) and 9 other tissues.

Summary

Enables signaling receptor binding activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Located in ciliary membrane and non-motile cilium. Is expressed in several structures, including adrenal gland; brain; gallbladder; genitourinary system; and gut. Orthologous to human SSTR3 (Somatostatin Receptor 3). [provided by Alliance of Genome Resources, Apr 2022]

Sstr3 Products (3)

mRNA Protein Name
NM_009218.3 NP_033244.2 somatostatin receptor type 3
NM_001411768.1 NP_001398697.1 somatostatin receptor type 3
NM_001356961.1 NP_001343890.1 somatostatin receptor type 3

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
23029470 MGI
Cellular Component GO Annotation Evidence References Source
located in ciliary membrane IDA
IDA: Inferred from direct assay
22179047 MGI
located in cilium IDA
IDA: Inferred from direct assay
22718903 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
23029470 MGI
located in non-motile cilium IDA
IDA: Inferred from direct assay
18334641 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
23029470 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sstr3 Protein Structure

7tm_GPCRs

7tm_GPCRs: cl28897 (45 - 332)

7tm_GPCRs

7tm_GPCRs: cd14964 (47 - 71)

7tm_GPCRs

7tm_GPCRs: cd14964 (80 - 101)

7tm_GPCRs

7tm_GPCRs: cd14964 (117 - 139)

7tm_GPCRs

7tm_GPCRs: cd14964 (162 - 178)

7tm_GPCRs

7tm_GPCRs: cd14964 (204 - 227)

7tm_GPCRs

7tm_GPCRs: cd14964 (264 - 286)

7tm_GPCRs

7tm_GPCRs: cd14964 (300 - 325)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 428 a.a.
Protein Preferred Names Protein Names

somatostatin receptor type 3

  • SS-3-R

  • SS3-R

  • SS3R

  • SSR-28

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P0036 Octreotide Agonist 99.96% Unkown
HY-P0036B Octreotide pamoate Agonist / Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-P0024 Veldoreotide Activator / Phase 2

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1932 Cortistatin-14 99.98% Unkown
HY-P1203 BIM-23056 Antagonist 99.98% Unkown
HY-P0024A Veldoreotide TFA Agonist 98.97% Unkown
HY-P4452 PRL 2915 Antagonist 99.92% Unkown
HY-P3618 Cortistatin-29 (reduced) 98.12% Unkown
HY-123335 L-796778 Agonist 98.00% Unkown
HY-P4469 PRL 3195 Antagonist / Unkown
HY-177493 SSTR3 Agonist-1 Agonist / Unkown
HY-123460 BN-81674 Antagonist / Unkown
HY-P2150 Cortistatin-29 (rat) / Unkown
HY-P1203A BIM-23056 TFA Antagonist / Unkown
HY-177493A SSTR3 agonist-1 TFA Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sstr3 NCBI NCBI:6753