Stat4 - signal transducer and activator of transcription 4 Gene

Species: Mus musculus

Gene Type: protein coding

Gene ID: 20849

Summary

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to Cytokines and Growth Factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. Homozygous knockout mice for this gene exhibit reduced inflammation and cytokine production in response to immune challenge. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Stat4 Products (2)

mRNA	Protein	Name
NM_001308266.1	NP_001295195.1	signal transducer and activator of transcription 4
NM_011487.5	NP_035617.1	signal transducer and activator of transcription 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	12213961	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	23772023	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12372421	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	18234692	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11894097	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cytokine-mediated signaling pathway	IDA IDA: Inferred from direct assay	11894097	MGI
acts upstream of or within hematopoietic stem cell homeostasis	IMP IMP: Inferred from mutant phenotype	26880577	MGI
acts upstream of or within leukocyte proliferation	IDA IDA: Inferred from direct assay	12213961	MGI
acts upstream of or within positive regulation of gene expression	IGI IGI: Inferred from genetic interaction	22851706	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19666510	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	23772023	MGI
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	11489994	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	12213961	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
signal transducer and activator of transcription 4

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-109854A	(R)-Lisofylline	Inhibitor	99.99%	Phase 2

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-173236	STAT4-IN-1	Inhibitor	99.17%	Unkown
HY-169360	SD-436	Degrader	98.27%	Unkown
HY-N0204	Pulchinenoside A	Activator	98.81%	Unkown
HY-161464	Chlopynostat		98.36%	Unkown
HY-173357	TYD-68		99.54%	Unkown
HY-172946	SD-2301	Degrader	/	Unkown
HY-RS13891	STAT4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-150895	SI-191	Ligand	/	Unkown
HY-RS17148	Stat4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23597	Stat4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Stat4	NCBI	NCBI:6775