STAT4 - signal transducer and activator of transcription 4 Gene

Also Known as SLEB11

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6775

About STAT4

Cytogenetic location: 2q32.2-q32.3 Genomic coordinates (GRCh38): 2:191,029,576-191,246,175 (from NCBI)

This gene has 11 transcripts (splice variants), 199 orthologues, 6 paralogues and is associated with 6 phenotypes. Broad expression in testis (RPKM 9.8), lymph node (RPKM 6.0) and 17 other tissues.

Summary

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to Cytokines and Growth Factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]

STAT4 Products (2)

mRNA	Protein	Name
NM_001243835.2	NP_001230764.1	signal transducer and activator of transcription 4
NM_003151.4	NP_003142.1	signal transducer and activator of transcription 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	31562212	GOA
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	37256972	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	18591661	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22740693	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in T-helper 1 cell differentiation	IDA IDA: Inferred from direct assay	14688310	GOA
involved in interleukin-12-mediated signaling pathway	IDA IDA: Inferred from direct assay	7638186	GOA
involved in response to interleukin-6	IMP IMP: Inferred from mutant phenotype	37256972	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of RNA polymerase II transcription regulator complex	IPI IPI: Inferred from physical interaction	18591661	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	7638186	GOA
located in nucleus	IMP IMP: Inferred from mutant phenotype	37256972	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STAT4 Protein Structure

STAT_int

STAT_alpha

STAT_bind

SH2

0
200
400
600
748 a.a.

Protein Preferred Names	Protein Names
signal transducer and activator of transcription 4

STAT4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	STAT4	Q14765	NUP58	Homo sapiens	Q9BVL2	Y2H Array	32814053
Intra	STAT4	Q14765	STAT1	Homo sapiens	P42224	BioID	35140242
Intra	STAT4	Q14765	STAT1	Homo sapiens	P42224	Anti Tag CoIP	33961781
Intra	STAT4	Q14765	NUP58	Homo sapiens	Q9BVL2	Y2H Pooling	32814053
Intra	STAT4	Q14765	STAT4	Homo sapiens	Q14765	GMS	18591661
Intra	STAT4	Q14765	STAT4	Homo sapiens	Q14765	Solution Sedimentation	18591661
Intra	STAT4	Q14765	SH2D1B	Homo sapiens	O14796	Validated Y2H	25814554
Intra	STAT4	Q14765	NUP58	Homo sapiens	Q9BVL2	Validated Y2H	32814053
Intra	STAT4	Q14765	LAMTOR5	Homo sapiens	O43504	Anti Bait CoIP	22740693

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant STAT4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76664	STAT4 Protein, Human (sf9, His)	Q14765 (M1-E748)	≥ 90%, as determined by reducing SDS-PAGE.

STAT4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80903	STAT4 Antibody (YA055)	WB, IHC-P, IP	Human
HY-P80903A	STAT4 Antibody (YA055)(PBS only)	WB, IHC-P, ICC/IF, IP, FC	Human

Related Diseases

Diseases	Alias
Systemic Lupus Erythematosus 11	Systemic Lupus Erythematosus, Susceptibility To, 11 SLEB11 Lupus Erythematosus, Systemic, Type 11
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Arthritis	Inflammatory Joint Disease Inflammatory Disorder Of Joint
Lupus Erythematosus	Lupus Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus, Systemic Subacute Cutaneous Lupus Le - [Lupus Erythematosus]
Pediatric Systemic Lupus Erythematosus	Sle, Pediatric Onset
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Oligoarticular Juvenile Idiopathic Arthritis	Oligoarticular Jia Pauciarticular Chronic Arthritis Juvenile Pauciarticular Chronic Arthritis
Rheumatoid Factor-Negative Polyarticular Juvenile Idiopathic Arthritis	Juvenile Polyarthritis Without Rheumatoid Factor Juvenile Rheumatoid Factor-Negative Polyarthritis Rheumatoid Factor-Negative Polyarticular Jia Polyarticular Juvenile Idiopathic Arthritis, Rheumatoid Factor Negative
Behcet Syndrome	Behcet Disease Behcet'S Syndrome Behcet'S Disease Behçet Disease Bd Adamantiades-Behcet Disease Triple Symptom Complex Behçet'S Disease Behet'S Syndrome Bd Syndrome Behçet Syndrome Behçet'S Syndrome Behcet Triple Symptom Complex Malignant Aphthosis Old Silk Route Disease Adamantiades-Behçet Disease
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease
Hepatitis B	Chronic Hepatitis B Hepatitis B Infection Serum Hepatitis HBV Hepatitis B Chronic Hbv, Susceptibility To Hepatitis B, Chronic Chronic Hepatitis B Without Delta Agent Chronic Hbv - [Hepatitis B Virus] Infection Hepatitis B Nos Chronic Type B Viral Hepatitis Hep B Nos
Sezary'S Disease	Sezary Syndrome Sézary Syndrome Sezary'S Lymphoma Sezary Disease Sezary Erythroderma Sezary Lymphoma
Systemic Scleroderma	Scleroderma Progressive Systemic Sclerosis Systemic Sclerosis Scleroderma, Systemic Scleroderma Syndrome Dermatosclerosis Familial Progressive Scleroderma Progressive Scleroderma Scleroderma Disease Scleroderma, Localized Diffuse Scleroderma Scleroderma, Familial Progressive
Leukodystrophy, Hypomyelinating, 8, With Or Without Oligodontia And/Or Hypogonadotropic Hypogonadism	Hypomyelinating Leukodystrophy 8 With Or Without Oligodontia And-Or Hypogonadotropic Hypogonadism HLD8 Cerebellar Hypoplasia With Endosteal Sclerosis 4h Leukodystrophy 2 Endosteal Sclerosis-Cerebellar Hypoplasia Syndrome Leukodystrophy, Hypomyelinating, Type 8, With/Without Oligodontia And/Or Hypogonadotropic Hypogonadism
Potocki-Shaffer Syndrome	Proximal 11p Deletion Syndrome Chromosome 11p11.2 Deletion Syndrome Pss 11p11.2 Deletion P11pds Defect11 Syndrome Deletion Of Chromosome 11p11.2 POSHS
Aphthous Stomatitis	Oral Ulcer Canker Sore Aphtha Aphthous Ulceration Oral Aphthae Oral Aphthous Ulcer Canker Sores Stomatitis, Aphthous Minor Oral Aphthous Ulceration
Autoimmune Disease Of Exocrine System
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Limited Scleroderma	Limited Cutaneous Systemic Sclerosis Limited Systemic Sclerosis Systemic Sclerosis Sine Scleroderma Crest Syndrome Limited Cutaneous Systemic Scleroderma Scleroderma, Limited Systemic Sclerosis, Limited Progressive Systemic Sclerosis Sine Scleroderma Scleroderma, Sine Crest - [Calcinosis, Raynaud Phenomenon, Oesophageal Dysmotility, Sclerodactyly, And Telangiectasia] Syndrome Crst - [Calcinosis, Raynaud Phenomenon, Sclerodactyly And Telangiectasia] Syndrome
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Primary Biliary Cholangitis	Primary Biliary Cirrhosis Biliary Liver Cirrhosis Chronic Nonsuppurative Destructive Cholangitis Familial Primary Biliary Cirrhosis Pbc Hanot Syndrome Cholestatic Cirrhosis Biliary Cirrhosis Primary Liver Cirrhosis, Biliary Hanot'S Cirrhosis Biliary Cirrhosis Pericholangiolic Biliary Cirrhosis Tannhauser-Magendantz Syndrome Hanot-Rossle Syndrome Hypertrophic Cirrhosis Todd Cirrhosis Hanot Cirrhosis Charcot Cirrhosis Mahon-Tannhauser Syndrome Toxic Cirrhosis Hypertrophic Biliary Cirrhosis Monolobular Cirrhosis Unilobar Cirrhosis Xanthomatous Biliary Cirrhosis
Celiac Disease 1	Celiac Disease Coeliac Disease Celiac Sprue Celiac Disease, Susceptibility To Gluten-Sensitive Enteropathy Nontropical Sprue Sprue CELIAC1 Celiac Disease, Susceptibility To, 1 Celiac Sprue 1 Celiac Sprue, Susceptibility To, 1 Gluten-Sensitive Enteropathy 1 Gluten-Sensitive Enteropathy, Susceptibility To, 1 Idiopathic Steatorrhea Cœliac Disease Gluten Intolerance Gluten-Induced Enteropathy Gluten Enteropathy Celiac Disease, Susceptibility To, Type 1 Childhood Celiac Disease Coeliac Rickets Gee Disease Gee-Herter Disease Heubner-Herter Disease Idiopathic Steatorrhoea Thaysen'S Disease Herter Gee Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-109854A	(R)-Lisofylline	Inhibitor	99.99%	Phase 2

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-173236	STAT4-IN-1	Inhibitor	99.17%	Unkown
HY-169360	SD-436	Degrader	98.27%	Unkown
HY-N0204	Pulchinenoside A	Activator	98.81%	Unkown
HY-161464	Chlopynostat		98.36%	Unkown
HY-173357	TYD-68		99.54%	Unkown
HY-172946	SD-2301	Degrader	/	Unkown
HY-RS13891	STAT4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-150895	SI-191	Ligand	/	Unkown
HY-RS17148	Stat4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23597	Stat4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	STAT4	MGD	MGI:103062
Bos taurus	STAT4	VGNC	VGNC:106954
Rattus norvegicus	STAT4	RGD	RGD:1305747
Macaca mulatta	STAT4	VGNC	VGNC:77907
Canis familiaris	STAT4	VGNC	VGNC:103708
Felis catus	STAT4	VGNC	VGNC:80367
Others	STAT4	NCBI