Tbx5 - T-box 5 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21388

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in heart development; positive regulation of gap junction assembly; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including cell communication involved in cardiac conduction; heart development; and positive regulation of cell population proliferation. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including embryo mesenchyme; eye; genitourinary system; heart; and vena cava. Used to study Holt-Oram syndrome. Human ortholog(s) of this gene implicated in Holt-Oram syndrome. Orthologous to human TBX5 (T-box transcription factor 5). [provided by Alliance of Genome Resources, Apr 2022]

Tbx5 Products (1)

mRNA Protein Name
NM_011537.3 NP_035667.1 T-box transcription factor TBX5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
11555635 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
22728936 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
11555635 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
22728936 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
14550786 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11572777 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within atrial septum development IMP
IMP: Inferred from mutant phenotype
19084512 MGI
acts upstream of or within atrial septum morphogenesis IGI
IGI: Inferred from genetic interaction
22898775 MGI
involved in atrioventricular bundle cell differentiation IMP
IMP: Inferred from mutant phenotype
15289437 MGI
involved in atrioventricular node cell development IMP
IMP: Inferred from mutant phenotype
15289437 MGI
involved in atrioventricular node cell fate commitment IMP
IMP: Inferred from mutant phenotype
15289437 MGI
acts upstream of or within atrioventricular valve morphogenesis IGI
IGI: Inferred from genetic interaction
19084512 MGI
acts upstream of positive effect bundle of His cell to Purkinje myocyte communication by electrical coupling IMP
IMP: Inferred from mutant phenotype
22728936 MGI
acts upstream of or within bundle of His development IGI
IGI: Inferred from genetic interaction
17604724 MGI
involved in bundle of His development IMP
IMP: Inferred from mutant phenotype
22728936 MGI
involved in cardiac left ventricle formation IMP
IMP: Inferred from mutant phenotype
19727199 MGI
acts upstream of or within cardiac muscle cell differentiation IGI
IGI: Inferred from genetic interaction
20691899 MGI
involved in cardiac muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
11431700 MGI
acts upstream of cardiac muscle cell proliferation IGI
IGI: Inferred from genetic interaction
19084512 MGI
acts upstream of positive effect cell-cell signaling IGI
IGI: Inferred from genetic interaction
22728936 MGI
acts upstream of or within embryonic forelimb morphogenesis IMP
IMP: Inferred from mutant phenotype
11572777 MGI
acts upstream of or within embryonic limb morphogenesis IGI
IGI: Inferred from genetic interaction
16380715 MGI
acts upstream of or within embryonic limb morphogenesis IMP
IMP: Inferred from mutant phenotype
12736217 MGI
acts upstream of or within endocardial cushion development IGI
IGI: Inferred from genetic interaction
19084512 MGI
acts upstream of or within forelimb morphogenesis IMP
IMP: Inferred from mutant phenotype
15621531 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
11572777 MGI
acts upstream of or within lung development IMP
IMP: Inferred from mutant phenotype
12508227 MGI
acts upstream of or within morphogenesis of an epithelium IMP
IMP: Inferred from mutant phenotype
12508227 MGI
acts upstream of or within pattern specification process IMP
IMP: Inferred from mutant phenotype
15289437 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11555635 MGI
acts upstream of positive regulation of cardiac conduction IMP
IMP: Inferred from mutant phenotype
22728936 MGI
acts upstream of or within positive regulation of cardiac muscle cell proliferation IGI
IGI: Inferred from genetic interaction
19084512 MGI
involved in positive regulation of gap junction assembly IMP
IMP: Inferred from mutant phenotype
22728936 MGI
acts upstream of or within positive regulation of secondary heart field cardioblast proliferation IMP
IMP: Inferred from mutant phenotype
22898775 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
22728936 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
16380715 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
24565863 MGI
acts upstream of or within regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
16870172 MGI
acts upstream of positive effect regulation of atrial cardiac muscle cell membrane depolarization IGI
IGI: Inferred from genetic interaction
22728936 MGI
involved in sinoatrial node development IMP
IMP: Inferred from mutant phenotype
11572777 MGI
acts upstream of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
17604724 MGI
acts upstream of or within ventricular cardiac muscle tissue development IGI
IGI: Inferred from genetic interaction
19084512 MGI
involved in ventricular septum development IMP
IMP: Inferred from mutant phenotype
19727199 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
11572777 MGI
part of transcription regulator complex IPI
IPI: Inferred from physical interaction
18285513 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

T-box transcription factor TBX5

  • T-box protein 5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14281 TBX5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174477 Mouse Tbx5 mRNA / Unkown
HY-174538 Human TBX5 mRNA / Unkown
HY-RS21440 Tbx5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27958 Tbx5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tbx5 NCBI NCBI:6910