Kdm5a - lysine (K)-specific demethylase 5A Gene

Also Known as RBP2; Rbbp2; Jarid1a

Species: Mus musculus

Gene Type: protein coding
Gene ID: 214899

Summary

Enables chromatin DNA binding activity and transcription coactivator activity. Involved in circadian regulation of gene expression and negative regulation of histone deacetylase activity. Acts upstream of or within histone H3-K4 demethylation and negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of protein-DNA complex. Is expressed in several structures, including 1st branchial arch; early conceptus; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in ankylosing spondylitis. Orthologous to human KDM5A (lysine demethylase 5A). [provided by Alliance of Genome Resources, Apr 2022]

Kdm5a Products (1)

mRNA Protein Name
NM_145997.2 NP_666109.2 lysine-specific demethylase 5A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chromatin DNA binding IDA
IDA: Inferred from direct assay
18483221 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
20064375 MGI
enables enzyme inhibitor activity IDA
IDA: Inferred from direct assay
21960634 MGI
enables histone H3K4 demethylase activity IMP
IMP: Inferred from mutant phenotype
18483221 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
20064375 MGI
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
21960634 MGI
Biological Process GO Annotation Evidence References Source
involved in circadian regulation of gene expression IMP
IMP: Inferred from mutant phenotype
21960634 MGI
involved in facultative heterochromatin formation IDA
IDA: Inferred from direct assay
20064375 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
18483221 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
18483221 MGI
part of protein-DNA complex IDA
IDA: Inferred from direct assay
18483221 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lysine-specific demethylase 5A

  • RBBP-2

  • [histone H3]-trimethyl-L-lysine(4) demethylase 5A

  • histone demethylase JARID1A

  • jumonji, AT rich interactive domain 1A (Rbp2 like)

  • jumonji/ARID domain-containing protein 1A

  • retinoblastoma binding protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (19)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100421 CPI-455 Inhibitor 98.95% Unkown
HY-147098 dTAG-47 Degrader 99.65% Unkown
HY-102047B KDOAM-25 citrate Inhibitor 98.56% Unkown
HY-107573 KDM2/7-IN-1 Inhibitor 99.9% Unkown
HY-100014 KDM5A-IN-1 Inhibitor 99.64% Unkown
HY-100421A CPI-455 hydrochloride Inhibitor 99.95% Unkown
HY-100624 Ryuvidine Inhibitor 99.23% Unkown
HY-119397A KDM5-C49 hydrochloride Inhibitor 98.22% Unkown
HY-158432 GT-653 Degrader 99.84% Unkown
HY-100764 YUKA1 Inhibitor 99.15% Unkown
HY-123419 CPI-4203 Inhibitor 99.0% Unkown
HY-144501 D18 98.79% Unkown
HY-102047 KDOAM-25 Inhibitor / Unkown
HY-119397 KDM5-C49 Inhibitor / Unkown
HY-RS07218 KDM5A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-102047A KDOAM-25 trihydrochloride Inhibitor / Unkown
HY-136682 N19-0881 Inhibitor / Unkown
HY-RS16664 Kdm5a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23099 Kdm5a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kdm5a NCBI NCBI:5927