2. Gene
  3. KDM5A - lysine demethylase 5A Gene

KDM5A - lysine demethylase 5A Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as RBP2; RBBP2; RBBP-2

Gene ID: 5927 | Gene type: protein coding

About KDM5A

Cytogenetic location: 12p13.33 Genomic coordinates (GRCh38): 12:280,057-389,320 (from NCBI)

This gene has 11 transcripts (splice variants), 211 orthologues, 10 paralogues and is associated with 97 phenotypes. Ubiquitous expression in testis (RPKM 10.6), bone marrow (RPKM 8.6) and 25 other tissues.

Summary

This gene encodes a member of the Jumonji, AT-rich interactive domain 1 (JARID1) Histone Demethylase protein family. The encoded protein plays a role in gene regulation through the histone code by specifically demethylating lysine 4 of histone H3. The encoded protein interacts with many other proteins, including retinoblastoma protein, and is implicated in the transcriptional regulation of Hox genes and cytokines. This gene may play a role in tumor progression. [provided by RefSeq, Aug 2013]

KDM5A Products(1)

mRNA Protein Name
NM_001042603.3 NP_001036068.1 lysine-specific demethylase 5A

KDM5A Protein Structure

JmjN

JmjN: jmjN domain (20 - 53)

ARID

ARID: ARID/BRIGHT DNA binding domain (82 - 170)

PHD

PHD: PHD-finger (295 - 342)

JmjC

JmjC: JmjC domain, hydroxylase (470 - 586)

zf-C5HC2

zf-C5HC2: C5HC2 zinc finger (676 - 729)

PLU-1

PLU-1: PLU-1-like protein (740 - 1072)

PHD

PHD: PHD-finger (1163 - 1217)

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  • 1690 a.a.
Protein Preferred Names Protein Names

lysine-specific demethylase 5A

Jumonji, AT rich interactive domain 1A (RBP2-like)

Related Diseases

Diseases Alias
Acute Megakaryoblastic Leukemia Without Down Syndrome

Non-Ds-Amkl
Retinoblastoma

RB

Trilateral Retinoblastoma

RB1

Retinoblastoma, Trilateral

Neuroblastoma Of Retina

Rb - Retinoblastoma

Eye Cancer, Retinoblastoma

Retinal Cancer

Retinal Tumor

Glioma, Retinal

Non-Hereditary Retinoblastoma

Childhood Cancer Retinoblastoma

Malignant Neoplasm Of Retina

Retinal Neoplasms
Childhood Acute Myeloid Leukemia

Childhood Acute Myeloid Leukaemia

Paediatric Acute Myeloid Leukaemia

Pediatric Acute Myeloid Leukemia
Childhood Acute Megakaryoblastic Leukemia

Pediatric Non-Down Syndrome Acute Megakaryoblastic Leukemia
Syndromic X-Linked Intellectual Disability Claes-Jensen Type

Mental Retardation, X-Linked, Syndromic, Claes-Jensen Type

Mrxscj

Mrxsj

Syndromic X-Linked Intellectual Disability Due To Jarid1c Mutation

Syndromic X-Linked Mental Retardation Jarid1c-Related
Myeloid Leukemia

Myeloid Leukaemia

Leukaemia Myelogenous

Leukemia Myelogenous

Myeloid Granulocytic Leukaemia

Myeloid Granulocytic Leukemia

Non-Lymphocytic Leukemia

Leukemia, Myeloid

Granulocytic Leukaemia

Myelogenous Leukaemia

Myeloid Leukaemia, Unspecified, Without Mention Of Remission
Idiopathic Peripheral Autonomic Neuropathy
Acute Megakaryocytic Leukemia

Acute Megakaryoblastic Leukemia

Acute Megakaryoblastic Leukaemia

Megakaryocytic Myelosis

Thrombocytic Leukaemia

Amkl

Aml M7

Acute Myeloblastic Leukemia Type 7

Acute Myeloid Leukemia M7

Megakaryoblastic Leukemia Acute

Leukemia, Megakaryoblastic, Acute

Acute Myeloid Leukaemia, M7

Acute Megakaryocytic Leukaemia

Acute Megakaryoblastic Leukaemia, Fab M7

Fab M7

Malignant Megakaryocytosis

M7 - Acute Megakaryoblastic Leukaemia

Megakaryoblastic Leukaemia

Megakaryocytic Leukaemia

Acute Megakaryoblastic Leukaemia, Nos

Acute Megakaryoblastic Leukaemia Without Mention Of Remission
Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (13)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100421 CPI-455 Inhibitor 98.95% Unkown
HY-102047B KDOAM-25 citrate Inhibitor 98.11% Unkown
HY-100014 KDM5A-IN-1 Inhibitor 99.80% Unkown
HY-144501 D18 98.79% Unkown
HY-100764 YUKA1 Inhibitor 99.56% Unkown
HY-119397A KDM5-C49 hydrochloride Inhibitor 99.95% Unkown
HY-107573 KDM2/7-IN-1 Inhibitor ≥99.0% Unkown
HY-123419 CPI-4203 Inhibitor ≥99.0% Unkown
HY-102047 KDOAM-25 Inhibitor / Unkown
HY-100421A CPI-455 hydrochloride Inhibitor / Unkown
HY-102047A KDOAM-25 trihydrochloride Inhibitor / Unkown
HY-119397 KDM5-C49 Inhibitor / Unkown
HY-RS07218 KDM5A Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus KDM5A VGNC VGNC:30530
Felis catus KDM5A VGNC VGNC:69256
Canis familiaris KDM5A VGNC VGNC:42327
Macaca mulatta KDM5A VGNC VGNC:82169
Mus musculus KDM5A MGD MGI:2136980
Rattus norvegicus KDM5A RGD RGD:1305429