Tgfb1 - transforming growth factor, beta 1 Gene

Also Known as Tgfb; Tgfb-1; TGFbeta1; TGF-beta1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 21803

About Tgfb1

Chromosome 7: 25,386,427-25,404,502 forward strand.GRCm39:CM001000.3

This gene has 5 transcripts (splice variants), 210 orthologues, 32 paralogues and is associated with 137 phenotypes. Broad expression in spleen adult (RPKM 74.6), thymus adult (RPKM 41.1) and 19 other tissues.

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with Other TGF-beta family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of Other growth factors including interferon gamma and tumor necrosis factor alpha. Mice lacking a functional copy of this gene develop severe multifocal inflammatory disease, yolk sac defects and colon Cancer. [provided by RefSeq, Aug 2016]

Tgfb1 Products (2)

mRNA	Protein	Name
NM_011577.2	NP_035707.1	transforming growth factor beta-1 proprotein preproprotein
NM_011577.2	NP_035707.1	transforming growth factor beta-1 proprotein preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12773577	MGI
enables protein serine/threonine kinase activator activity	IDA IDA: Inferred from direct assay	25065622	MGI
enables transforming growth factor beta receptor binding	IPI IPI: Inferred from physical interaction	17878231	MGI

Biological Process GO Annotation	Evidence	Références	Source
acts upstream of or within Langerhans cell differentiation	IMP IMP: Inferred from mutant phenotype	17938236	MGI
acts upstream of or within Notch signaling pathway	IDA IDA: Inferred from direct assay	25446530	MGI
acts upstream of or within T cell activation	IDA IDA: Inferred from direct assay	18997793	MGI
acts upstream of T cell activation	IMP IMP: Inferred from mutant phenotype	12646629	MGI
acts upstream of or within T cell activation	IMP IMP: Inferred from mutant phenotype	17481928	MGI
acts upstream of or within T cell differentiation	IMP IMP: Inferred from mutant phenotype	17481928	MGI
acts upstream of or within T cell homeostasis	IMP IMP: Inferred from mutant phenotype	17481928	MGI
acts upstream of T cell proliferation	IMP IMP: Inferred from mutant phenotype	17481928	MGI
involved in adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	IDA IDA: Inferred from direct assay	19501566	MGI
involved in aortic valve morphogenesis	IMP IMP: Inferred from mutant phenotype	26634652	MGI
acts upstream of or within branch elongation involved in mammary gland duct branching	IMP IMP: Inferred from mutant phenotype	18614704	MGI
acts upstream of or within bronchiole development	IDA IDA: Inferred from direct assay	12634787	MGI
acts upstream of or within bronchiole development	IMP IMP: Inferred from mutant phenotype	12634787	MGI
acts upstream of or within canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	29715368	MGI
acts upstream of or within cell activation	IDA IDA: Inferred from direct assay	21956870	MGI
acts upstream of or within cell morphogenesis	IDA IDA: Inferred from direct assay	17641300	MGI
acts upstream of cell population proliferation	IDA IDA: Inferred from direct assay	15604101	MGI
acts upstream of or within cellular response to growth factor stimulus	IDA IDA: Inferred from direct assay	7848824	MGI
acts upstream of or within cellular response to ionizing radiation	IMP IMP: Inferred from mutant phenotype	17916808	MGI
acts upstream of or within cellular response to transforming growth factor beta stimulus	IDA IDA: Inferred from direct assay	23861879	MGI
involved in cellular response to virus	IDA IDA: Inferred from direct assay	18802055	MGI
acts upstream of or within columnar/cuboidal epithelial cell maturation	IMP IMP: Inferred from mutant phenotype	31336344	MGI
acts upstream of or within connective tissue development	IGI IGI: Inferred from genetic interaction	25715398	MGI
involved in embryonic liver development	IMP IMP: Inferred from mutant phenotype	7600998	MGI
acts upstream of or within endoderm development	IDA IDA: Inferred from direct assay	9921650	MGI
acts upstream of or within epithelial cell proliferation	IDA IDA: Inferred from direct assay	12208849	MGI
involved in extracellular matrix assembly	IDA IDA: Inferred from direct assay	19734317	MGI
involved in face morphogenesis	IEP IEP: Inferred from expression pattern	18498113	MGI
acts upstream of or within gene expression	IDA IDA: Inferred from direct assay	29715368	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	18802055	MGI
acts upstream of or within germ cell migration	IDA IDA: Inferred from direct assay	15993878	MGI
involved in heart development	IMP IMP: Inferred from mutant phenotype	7600998	MGI
involved in heart valve morphogenesis	IMP IMP: Inferred from mutant phenotype	8009224	MGI
acts upstream of or within inflammatory response	IMP IMP: Inferred from mutant phenotype	1436033	MGI
acts upstream of or within intracellular calcium ion homeostasis	IMP IMP: Inferred from mutant phenotype	12646629	MGI
acts upstream of or within lens fiber cell differentiation	IMP IMP: Inferred from mutant phenotype	17215516	MGI
acts upstream of or within lung alveolus development	IDA IDA: Inferred from direct assay	12634787	MGI
acts upstream of or within lymph node development	IMP IMP: Inferred from mutant phenotype	1436033	MGI
acts upstream of or within mammary gland branching involved in thelarche	IMP IMP: Inferred from mutant phenotype	18614704	MGI
acts upstream of or within mammary gland development	IDA IDA: Inferred from direct assay	1821856	MGI
acts upstream of or within mononuclear cell proliferation	IMP IMP: Inferred from mutant phenotype	17481928	MGI
acts upstream of or within muscle cell cellular homeostasis	IGI IGI: Inferred from genetic interaction	25715398	MGI
acts upstream of or within negative regulation of T cell activation	IMP IMP: Inferred from mutant phenotype	12646629	MGI
acts upstream of or within negative regulation of T cell proliferation	IMP IMP: Inferred from mutant phenotype	17481928	MGI
involved in negative regulation of biomineral tissue development	IMP IMP: Inferred from mutant phenotype	26634652	MGI
involved in negative regulation of cell growth	IDA IDA: Inferred from direct assay	12773577	MGI
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	26634652	MGI
involved in negative regulation of interleukin-17 production	IDA IDA: Inferred from direct assay	18368049	MGI
acts upstream of or within negative regulation of ossification	IDA IDA: Inferred from direct assay	15820682	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15657445	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15990875	MGI
involved in neural tube closure	IMP IMP: Inferred from mutant phenotype	7600998	MGI
involved in neural tube development	IMP IMP: Inferred from mutant phenotype	7600998	MGI
acts upstream of or within neuron apoptotic process	IDA IDA: Inferred from direct assay	29715368	MGI
involved in odontoblast differentiation	IMP IMP: Inferred from mutant phenotype	33548622	MGI
involved in oligodendrocyte development	IMP IMP: Inferred from mutant phenotype	22384214	MGI
acts upstream of or within osteoclast differentiation	IDA IDA: Inferred from direct assay	21841309	MGI
acts upstream of or within osteoclast differentiation	IGI IGI: Inferred from genetic interaction	21841309	MGI
acts upstream of or within phospholipid homeostasis	IDA IDA: Inferred from direct assay	17641300	MGI
acts upstream of or within phospholipid homeostasis	IMP IMP: Inferred from mutant phenotype	17641300	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15100250	MGI
involved in positive regulation of SMAD protein signal transduction	IDA IDA: Inferred from direct assay	12773577	MGI
involved in positive regulation of collagen biosynthetic process	IDA IDA: Inferred from direct assay	19734317	MGI
acts upstream of or within positive regulation of epithelial to mesenchymal transition	IDA IDA: Inferred from direct assay	18794329	MGI
acts upstream of positive regulation of extracellular matrix assembly	IDA IDA: Inferred from direct assay	24279830	MGI
acts upstream of or within positive regulation of fibroblast migration	IMP IMP: Inferred from mutant phenotype	23871832	MGI
acts upstream of or within positive regulation of fibroblast proliferation	IDA IDA: Inferred from direct assay	23871832	MGI
acts upstream of or within positive regulation of gene expression	IDA IDA: Inferred from direct assay	17293613	MGI
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	21984612	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	26634652	MGI
involved in positive regulation of interleukin-17 production	IDA IDA: Inferred from direct assay	19501566	MGI
involved in positive regulation of microglia differentiation	IMP IMP: Inferred from mutant phenotype	29909984	MGI
acts upstream of or within positive regulation of odontogenesis	IDA IDA: Inferred from direct assay	7848824	MGI
acts upstream of or within positive regulation of protein localization to nucleus	IGI IGI: Inferred from genetic interaction	21911934	MGI
involved in positive regulation of regulatory T cell differentiation	IMP IMP: Inferred from mutant phenotype	25065622	MGI
acts upstream of or within positive regulation of stem cell proliferation	IDA IDA: Inferred from direct assay	15604101	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15990875	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	17568773	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	31336344	MGI
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	12208849	MGI
acts upstream of or within protein phosphorylation	IGI IGI: Inferred from genetic interaction	17898001	MGI
acts upstream of or within regulation of DNA binding	IDA IDA: Inferred from direct assay	15282343	MGI
acts upstream of or within regulation of actin cytoskeleton organization	IGI IGI: Inferred from genetic interaction	21911934	MGI
acts upstream of or within regulation of binding	IDA IDA: Inferred from direct assay	15282343	MGI
acts upstream of or within regulation of branching involved in mammary gland duct morphogenesis	IGI IGI: Inferred from genetic interaction	17898001	MGI
acts upstream of or within regulation of cartilage development	IDA IDA: Inferred from direct assay	20501701	MGI
acts upstream of or within regulation of cell cycle	IDA IDA: Inferred from direct assay	19056892	MGI
acts upstream of or within regulation of cell population proliferation	IDA IDA: Inferred from direct assay	11799106	MGI
acts upstream of regulation of enamel mineralization	IMP IMP: Inferred from mutant phenotype	30243146	MGI
NOT involved in regulation of epithelial to mesenchymal transition involved in endocardial cushion formation	IMP IMP: Inferred from mutant phenotype	19161227	MGI
acts upstream of or within regulation of gene expression	IDA IDA: Inferred from direct assay	23871832	MGI
involved in regulation of interleukin-23 production	IDA IDA: Inferred from direct assay	18368049	MGI
acts upstream of or within regulation of protein import into nucleus	IDA IDA: Inferred from direct assay	11799106	MGI
acts upstream of or within regulation of regulatory T cell differentiation	IGI IGI: Inferred from genetic interaction	21245484	MGI
acts upstream of or within regulation of sodium ion transport	IDA IDA: Inferred from direct assay	16941024	MGI
acts upstream of or within regulation of striated muscle tissue development	IDA IDA: Inferred from direct assay	11711431	MGI
acts upstream of or within regulatory T cell differentiation	IDA IDA: Inferred from direct assay	15100250	MGI
acts upstream of or within regulatory T cell differentiation	IMP IMP: Inferred from mutant phenotype	17481928	MGI
acts upstream of or within retina vasculature development in camera-type eye	IDA IDA: Inferred from direct assay	29715368	MGI
acts upstream of stem cell proliferation	IDA IDA: Inferred from direct assay	15604101	MGI
acts upstream of or within surfactant homeostasis	IDA IDA: Inferred from direct assay	17641300	MGI
acts upstream of or within surfactant homeostasis	IMP IMP: Inferred from mutant phenotype	17641300	MGI
acts upstream of or within tolerance induction to self antigen	IMP IMP: Inferred from mutant phenotype	17481928	MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	12208849	MGI
involved in transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	12773577	MGI
involved in transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	8009224	MGI
involved in ureteric bud development	IEP IEP: Inferred from expression pattern	14656760	MGI
involved in vasculogenesis	IMP IMP: Inferred from mutant phenotype	7600998	MGI
involved in ventricular cardiac muscle tissue morphogenesis	IMP IMP: Inferred from mutant phenotype	8009224	MGI

Cellular Component GO Annotation	Evidence	Références	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	31336344	MGI
located in extracellular matrix	IDA IDA: Inferred from direct assay	2209468	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	18753609	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tgfb1 Protein Structure

TGFb_propeptide

TGF_beta_TGFB1

0
100
200
300
390 a.a.

Protein Preferred Names	Protein Names
transforming growth factor beta-1 proprotein
transforming growth factor beta-1 proprotein

Recombinant Tgfb1 Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P7117	TGF beta 1/TGFB1 Protein, Mouse/Rat (HEK293, Tag Free)	P04202/P17246 (A279-S390)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70648	TGF beta 1/TGFB1 Protein, Mouse/Rat (HEK293)	P04202/P17246 (A279-S390)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77677	GARP&Latent TGF beta Complex Protein, Mouse (HEK293, His)	G3XA59 (A18-L628)&P04202 (L30-S390)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P77678	GARP&Latent TGF beta Complex Protein, Mouse (Biotinylated, HEK293, His-Avi)	G3XA59 (I18-N628)&P04202 (L30-S390)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78360	Latent TGF beta 1/TGFB1 Protein, Mouse (HEK293, His)	P04202 (L30-S390)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P700227AF	Animal-Free TGF beta 1/TGFB1 Protein, Mouse/Rat (His)	P04202/P17246 (A279-S390)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (4)

Cat. No.	Nom du produit	Effect	Pureté	Phase
HY-P99305	Metelimumab	Inhibitor	98.98%	Phase 2
HY-P991382	SAR-439459	Inhibitor	99.41%	Phase 2
HY-P991383	LY2382770	Inhibitor	/	Phase 2
HY-P991950	SHR-1906	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS14435	TGFB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W764758	3-OH-Kynurenamine dihydroiodide	Activator	99.56%	Unkown
HY-RS14436	Tgfb1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-147195	QH536	Inhibitor	/	Unkown
HY-156908	3-OH-Kynurenamine	Activator	/	Unkown
HY-RS14437	Tgfb1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14438	TGFB1I1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174534	Human TGFB1 mRNA		/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-P99606	Cirevetmab	Inhibitor	≥99.0%	Unkown
HY-P990517	Anti-TGFb1 Antibody	Inhibitor	98.24%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tgfb1	NCBI	NCBI:7040