Tle3 - transducin-like enhancer of split 3 Gene

Also Known as ESG; Grg3a; Grg3b; mKIAA1547; 2610103N05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21887

Summary

Predicted to enable transcription corepressor activity. Involved in negative regulation of cold-induced thermogenesis. Predicted to be located in nucleoplasm. Predicted to be part of beta-catenin-TCF complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human TLE3 (TLE family member 3, transcriptional corepressor). [provided by Alliance of Genome Resources, Apr 2022]

Tle3 Products (3)

mRNA Protein Name
NM_001083927.1 NP_001077396.1 transducin-like enhancer protein 3 isoform 1
NM_001083928.1 NP_001077397.1 transducin-like enhancer protein 3 isoform 3
NM_009389.2 NP_033415.2 transducin-like enhancer protein 3 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17202186 MGI
Biological Process GO Annotation Evidence References Source
involved in negative regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
23473036 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transducin-like enhancer protein 3

  • grg-3

  • transducin-like enhancer of split 3, homolog of Drosophila E(spl)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14565 TLE3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19963 Tle3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26465 Tle3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tle3 NCBI NCBI:7090