Cd70 - CD70 antigen Gene

Also Known as Cd27l; CD27LG; Tnfsf7; Tnlg8a

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21948

Summary

Predicted to enable cytokine activity and protease binding activity. Predicted to be involved in several processes, including B cell proliferation; T cell mediated immunity; and extrinsic apoptotic signaling pathway. Predicted to be located in extracellular space and membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in Meckel's cartilage; hip; and skeleton. Human ortholog(s) of this gene implicated in lymphoproliferative syndrome. Orthologous to human CD70 (CD70 molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd70 Products (1)

mRNA Protein Name
NM_011617.2 NP_035747.1 CD70 antigen

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables receptor ligand activity IDA
IDA: Inferred from direct assay
9366422 MGI
Biological Process GO Annotation Evidence References Source
involved in T cell proliferation IDA
IDA: Inferred from direct assay
9366422 MGI
Cellular Component GO Annotation Evidence References Source
is active in plasma membrane IDA
IDA: Inferred from direct assay
9366422 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

CD70 antigen

  • CD27 ligand

  • CD27-L

  • Ki-24 antigen

  • tumor necrosis factor ligand 8a

  • tumor necrosis factor ligand superfamily member 7

Recombinant Cd70 Proteins

Cat. No. Product Name Accession Purity
HY-P72741 CD70 Protein, Mouse (HEK293, His) Q05A52 (Q47-P195) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72928 CD70 Protein, Mouse (HEK293, mFc) Q05A52 (Q47-P195) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72741AF Animal-Free CD70 Protein, Mouse (His) Q05A52 (Q47-P195) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-185484 MDX-1203 Inhibitor / Phase 1
Inhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Phase
HY-P99014 Cusatuzumab Inhibitor 98.87% Phase 2
HY-P99334 Vorsetuzumab mafodotin Inhibitor 99.69% Phase 1
HY-P991562 MDX-1411 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-160649 MC-Gly-Gly-Phe-Gly-GABA-Exatecan Inhibitor 99.72% Unkown
HY-178271 P-SCN-Bn-NOTA 95.0% Unkown
HY-174736 Human CD70 mRNA 90% Unkown
HY-178257 Fmoc-Val-Lys-PAB-Exatecan / Unkown
HY-RS02264 CD70 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16751 Cd70 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23190 Cd70 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99273 Vorsetuzumab Inhibitor 99.29% Unkown
HY-P990264 Anti-Mouse CD70 Antibody (FR70) Inhibitor 95.00% Unkown
HY-P990261 Anti-Mouse CD83 Antibody (Michel-17) Inhibitor 98.722% Unkown
HY-P991120 Balertatug Inhibitor 98.84% Unkown
HY-P991645 MDX-1115 98.86% Unkown
HY-P991809 Anti-Mouse CD70 Antibody (TAN 1-7) Inhibitor / Unkown
HY-P991930 ARX305 Antibody / Unkown
HY-P99014A Cusatuzumab (FUT8-KO) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cd70 NCBI NCBI:970