1. Inhibitory Antibodies
  2. Vorsetuzumab

Vorsetuzumab  (Synonyms: Anti-Human CD70 Recombinant Antibody)

Cat. No.: HY-P99273 Purity: 95.00%
COA

Vorsetuzumab (Anti-Human CD70 Recombinant Antibody) is a human anti-CD70 antibody. Vorsetuzumab enhances macrophage-related phagocytosis of renal carcinoma cells, shows inhibitory efficacy against Burkitt’s lymphoma.

For research use only. We do not sell to patients.

Vorsetuzumab Chemical Structure

Vorsetuzumab Chemical Structure

CAS No. : 1165740-62-4

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Based on 1 publication(s) in Google Scholar

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Description

Vorsetuzumab (Anti-Human CD70 Recombinant Antibody) is a human anti-CD70 antibody. Vorsetuzumab enhances macrophage-related phagocytosis of renal carcinoma cells, shows inhibitory efficacy against Burkitt’s lymphoma[1].

IC50 & Target

CD70[1]

In Vitro

Vorsetuzumab (10 μg/mL; 2 h) augments macrophage-dependent phagocytosis of renal carcinoma cells in vitro[1].
Vorsetuzumab (10 μg/mL; 2 h) can be developed into bispecific anti-human CD70/KWAR23 antibody, results KWAR23 moderately induced macrophage phagocytosis of four renal carcinoma cell lines (RCC4, RCC10, TK10, and Caki-1)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Vorsetuzumab (10 mg/kg; i.p.; every other day; for 12 d) inhibits Burkitt’s lymphoma cell growth growth in SRG mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Burkitt’s lymphoma xenograft model in SRG mice[1]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; every other day; for 12 d
Result: Effectively inhibited Burkitt’s lymphoma cell growth but was not outperform the combination of the KWAR23 antibody (10 mg/kg).
Molecular Weight

146.1 (kDa)

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Vorsetuzumab]

Shipping

Shipping with dry ice.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Purity: 95.00%

References
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Vorsetuzumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Vorsetuzumab
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HY-P99273
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