2. Antibody-drug Conjugate/ADC Related Immunology/Inflammation
  3. Antibody-Drug Conjugates (ADCs) Transmembrane Glycoprotein
  4. MDX-1203

MDX-1203 (BMS-936561) is an antibody-drug conjugate targeting CD70. MDX-1203 binds to CD70 and mediates the specific delivery of its conjugated cytotoxic payload to tumors. MDX-1203 delivers a DNA alkylating payload into cells. MDX-1203 can be used in research related to advanced clear cell renal cell carcinoma and relapsed/refractory B-cell non-Hodgkin lymphoma.

For research use only. We do not sell to patients.

MDX-1203

MDX-1203 Chemical Structure

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MDX-1203 Related Antibodies

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Description

MDX-1203 (BMS-936561) is an antibody-drug conjugate targeting CD70. MDX-1203 binds to CD70 and mediates the specific delivery of its conjugated cytotoxic payload to tumors. MDX-1203 delivers a DNA alkylating payload into cells. MDX-1203 can be used in research related to advanced clear cell renal cell carcinoma and relapsed/refractory B-cell non-Hodgkin lymphoma[1][2].

In Vitro

MDX-1203 binds CD70 with nanomolar affinity, induces dose-dependent cell death in CD70-expressing human tumor cell lines, and mediates antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) following internalization[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MDX-1203 Related Antibodies
In Vivo

MDX-1203 (4-38 mg/kg; single dose, 2 doses) exhibits dose-dependent efficacy in a murine 786-O renal cell carcinoma xenograft model, with complete tumor regression achieved with two 38 mg/kg doses[2].
MDX-1203 (10-100 mg/kg; i.v.; single dose, every 2 weeks; 3 doses) is safe at single 25 mg/kg and 100 mg/kg intravenous doses and repeated 10 mg/kg and 25 mg/kg intravenous doses every 2 weeks for 3 doses in Rattus norvegicus, but a single 50 mg/kg intravenous dose causes severe toxicity[2].
MDX-1203 (50 mg/kg; i.v.; repeated doses) is well tolerated in cynomolgus monkeys[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: unspecified strain[2]
Dosage: 25 mg/kg (single i.v. dose); 100 mg/kg (single i.v. dose); 50 mg/kg (single i.v. dose); 10 mg/kg (i.v., every 2 weeks for 3 doses); 25 mg/kg (i.v., every 2 weeks for 3 doses)
Administration: i.v.; single dose; i.v.; every 2 weeks; 3 doses
Result: Were safe in single intravenous doses of 25 mg/kg and 100 mg/kg.
Resulted in severe toxicity (greater than 10% decrease in body weight compared to control animals) with a single 50 mg/kg intravenous dose.
Were safe with repeated intravenous doses of 10 mg/kg and 25 mg/kg (every 2 weeks for 3 doses).
Clinical Trial
SMILES

[2H][M][X1203]
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Purity & Documentation
References
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MDX-1203 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MDX-1203BMS-936561MDX1203MDX 1203BMS936561BMS 936561Antibody-Drug Conjugates (ADCs)Transmembrane GlycoproteinAntibody-Drug Conjugatesclear cell renal cell carcinomaDNA alkylating payloadratsB-cell non-Hodgkin lymphomahuman tumor cell lines786-O renal cell carcinoma xenograft modelcynomolgus monkeysCDCCD70ADCCInhibitorinhibitorinhibit

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