Top2a - topoisomerase (DNA) II alpha Gene

Also Known as Top-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21973

About Top2a

Chromosome 11: 98,883,769-98,915,015 reverse strand.GRCm39:CM001004.3

This gene has 7 transcripts (splice variants), 205 orthologues, 1 paralogue and is associated with 29 phenotypes. Biased expression in CNS E11.5 (RPKM 79.9), liver E14 (RPKM 47.8) and 1 other tissues.

Summary

Enables DNA Topoisomerase type II (double strand cut, ATP-hydrolyzing) activity. Involved in female meiotic nuclear division and regulation of circadian rhythm. Acts upstream of or within several processes, including DNA conformation change; embryonic cleavage; and hematopoietic progenitor cell differentiation. Located in chromosome, centromeric region; condensed chromosome; and nucleolus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human TOP2A (DNA Topoisomerase II alpha). [provided by Alliance of Genome Resources, Apr 2022]

Top2a Products (1)

mRNA Protein Name
NM_011623.2 NP_035753.2 DNA topoisomerase 2-alpha

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity IDA
IDA: Inferred from direct assay
1331984 MGI
enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity IGI
IGI: Inferred from genetic interaction
1331984 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
23698369 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within DNA topological change IDA
IDA: Inferred from direct assay
1331984 MGI
acts upstream of or within chromosome condensation IMP
IMP: Inferred from mutant phenotype
11835580 MGI
acts upstream of or within chromosome segregation IDA
IDA: Inferred from direct assay
7842491 MGI
acts upstream of or within chromosome segregation IMP
IMP: Inferred from mutant phenotype
11835580 MGI
acts upstream of or within embryonic cleavage IMP
IMP: Inferred from mutant phenotype
11835580 MGI
involved in female meiotic nuclear division IMP
IMP: Inferred from mutant phenotype
25961503 MGI
acts upstream of or within hematopoietic progenitor cell differentiation IMP
IMP: Inferred from mutant phenotype
24029230 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
1683482 MGI
involved in regulation of circadian rhythm IMP
IMP: Inferred from mutant phenotype
24321095 MGI
Cellular Component GO Annotation Evidence References Source
located in chromosome, centromeric region IDA
IDA: Inferred from direct assay
26919979 MGI
located in condensed chromosome IDA
IDA: Inferred from direct assay
11835579 MGI
located in condensed chromosome IMP
IMP: Inferred from mutant phenotype
21795393 MGI
located in male germ cell nucleus IDA
IDA: Inferred from direct assay
9094096 MGI
located in nucleolus IDA
IDA: Inferred from direct assay
11835579 MGI
is active in nucleus IDA
IDA: Inferred from direct assay
25961503 MGI
located in nucleus IDA
IDA: Inferred from direct assay
9224616 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Top2a Protein Structure

PTZ00108

PTZ00108: PTZ00108 (23 - 1440)

DTHCT

DTHCT: pfam08070 (1430 - 1517)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1528 a.a.
Protein Preferred Names Protein Names

DNA topoisomerase 2-alpha

  • DNA Topoisomerase II alpha

  • DNA topoisomerase II, alpha isozyme

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-111630 PluriSIn #2 Inhibitor 98.0% Unkown
HY-174374 Topobexin Inhibitor 99.04% Unkown
HY-164143 T638 Inhibitor 98.61% Unkown
HY-123393 PNU-142586 Inhibitor 97.92% Unkown
HY-RS14894 TOP2A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-175834 DNA/TOP2A-IN-1 / Unkown
HY-RS14895 Top2a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14896 Top2a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W654323 PNU-142586 sodium Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Top2a NCBI NCBI:7153