Top2a - topoisomerase (DNA) II alpha Gene

Mus musculus

Also known as Top-2

Gene ID: 21973 | Gene type: protein coding

About Top2a

Chromosome 11: 98,883,769-98,915,015 reverse strand.GRCm39:CM001004.3

This gene has 7 transcripts (splice variants), 205 orthologues, 1 paralogue and is associated with 29 phenotypes. Biased expression in CNS E11.5 (RPKM 79.9), liver E14 (RPKM 47.8) and 1 other tissues.

Summary

Enables DNA Topoisomerase type II (double strand cut, ATP-hydrolyzing) activity. Involved in female meiotic nuclear division and regulation of circadian rhythm. Acts upstream of or within several processes, including DNA conformation change; embryonic cleavage; and hematopoietic progenitor cell differentiation. Located in chromosome, centromeric region; condensed chromosome; and nucleolus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human TOP2A (DNA Topoisomerase II alpha). [provided by Alliance of Genome Resources, Apr 2022]

Top2a Products(1)

mRNA	Protein	Name
NM_011623.2	NP_035753.2	DNA topoisomerase 2-alpha

Top2a Protein Structure

PTZ00108

DTHCT

0
300
600
900
1200
1528 a.a.

Protein Preferred Names

Protein Names

DNA topoisomerase 2-alpha

DNA Topoisomerase II alpha

DNA topoisomerase II, alpha isozyme

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-111630	PluriSIn #2	Inhibitor	≥98.0%	Unkown
HY-RS14894	TOP2A Human Pre-designed siRNA Set A		/	Unkown
HY-RS14895	Top2a Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS14896	Top2a Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Top2a	NCBI	NCBI:7153

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