Traf2 - TNF receptor-associated factor 2 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22030

Summary

Enables CD40 receptor binding activity. Involved in several processes, including interleukin-17-mediated signaling pathway; positive regulation of signal transduction; and regulation of gene expression. Acts upstream of or within several processes, including cellular response to nitric oxide; programmed necrotic cell death; and regulation of JNK cascade. Located in several cellular components, including cytoplasmic side of plasma membrane; membrane raft; and vesicle membrane. Part of CD40 receptor complex and IRE1-TRAF2-ASK1 complex. Is expressed in several structures, including genitourinary system; lower jaw tooth; and mandibular process. Orthologous to human TRAF2 (TNF Receptor associated factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Traf2 Products (2)

mRNA Protein Name
NM_001290413.1 NP_001277342.1 TNF receptor-associated factor 2 isoform a
NM_009422.3 NP_033448.2 TNF receptor-associated factor 2 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables CD40 receptor binding IPI
IPI: Inferred from physical interaction
20614026 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9418902 MGI
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
18281285 MGI
enables signaling adaptor activity IDA
IDA: Inferred from direct assay
8710854 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to nitric oxide IMP
IMP: Inferred from mutant phenotype
18007661 MGI
involved in interleukin-17-mediated signaling pathway IDA
IDA: Inferred from direct assay
21822258 MGI
involved in interleukin-17-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
21822258 MGI
involved in mRNA stabilization IMP
IMP: Inferred from mutant phenotype
21822258 MGI
involved in positive regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
15121867 MGI
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
8710854 MGI
involved in positive regulation of tumor necrosis factor-mediated signaling pathway IDA
IDA: Inferred from direct assay
11374864 MGI
acts upstream of or within programmed necrotic cell death IMP
IMP: Inferred from mutant phenotype
18007661 MGI
acts upstream of or within protein catabolic process IMP
IMP: Inferred from mutant phenotype
12958312 MGI
involved in protein-containing complex assembly IDA
IDA: Inferred from direct assay
20614026 MGI
acts upstream of or within regulation of JNK cascade IDA
IDA: Inferred from direct assay
12958312 MGI
acts upstream of or within regulation of immunoglobulin production IMP
IMP: Inferred from mutant phenotype
12958312 MGI
acts upstream of or within signal transduction IDA
IDA: Inferred from direct assay
12958312 MGI
involved in signal transduction involved in regulation of gene expression IDA
IDA: Inferred from direct assay
21822258 MGI
involved in signal transduction involved in regulation of gene expression IMP
IMP: Inferred from mutant phenotype
21822258 MGI
involved in tumor necrosis factor-mediated signaling pathway IDA
IDA: Inferred from direct assay
8710854 MGI
Cellular Component GO Annotation Evidence References Source
part of CD40 receptor complex IDA
IDA: Inferred from direct assay
20614026 MGI
part of IRE1-TRAF2-ASK1 complex IDA
IDA: Inferred from direct assay
12050113 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
11821416 MGI
located in cytoplasmic side of plasma membrane IDA
IDA: Inferred from direct assay
20614026 MGI
located in cytosol IDA
IDA: Inferred from direct assay
18007661 MGI
located in membrane raft IDA
IDA: Inferred from direct assay
18007661 MGI
located in vesicle membrane IDA
IDA: Inferred from direct assay
18952128 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

TNF receptor-associated factor 2

  • E3 ubiquitin-protein ligase TRAF2

  • RING-type E3 ubiquitin transferase TRAF2

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-19696B Tauroursodeoxycholate dihydrate 99.96% Yes

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-16591 Birinapant 99.70% Phase 2

Pre-clinical Phase

Bioactive Molecules (19)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100830 NCB-0846 Inhibitor 99.61% Unkown
HY-134050 Apostatin-1 99.64% Unkown
HY-138779 ICCB-19 hydrochloride 99.25% Unkown
HY-124745 KY-05009 99.88% Unkown
HY-117469 Triptohypol C 96.56% Unkown
HY-153598 LD4172 98.32% Unkown
HY-145293 TNIK-IN-3 Inhibitor 99.79% Unkown
HY-124762 TNIK-IN-1 Inhibitor 99.25% Unkown
HY-156502 TINK-IN-1 Inhibitor 98.02% Unkown
HY-122805 PF-794 Inhibitor 99.19% Unkown
HY-156818 TNIK-IN-7 Inhibitor 99.65% Unkown
HY-100830A NCB-0970 Control 98.81% Unkown
HY-156817 TNIK-IN-6 Inhibitor 98.28% Unkown
HY-145292 TNIK-IN-2 Inhibitor 99.68% Unkown
HY-RS14197 TANK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14968 TRAF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174514 Human TNFRSF4 mRNA / Unkown
HY-RS16859 Traf2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23300 Traf2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Traf2 NCBI NCBI:7186