Vwf - Von Willebrand factor Gene

Also Known as VWD; F8VWF; C630030D09; 6820430P06Rik; B130011O06Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22371

Summary

Predicted to enable several functions, including chaperone binding activity; identical protein binding activity; and Integrin binding activity. Acts upstream of or within several processes, including liver development; placenta development; and platelet activation. Located in external side of plasma membrane. Is expressed in several structures, including cardiovascular system; extraembryonic component; genitourinary system; leptomeninges; and vitelline blood vessel. Used to study von Willebrand's disease and von Willebrand's disease 2. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; Bernard-Soulier syndrome; end stage renal disease; essential thrombocythemia; and von Willebrand's disease (multiple). Orthologous to human VWF (von Willebrand factor). [provided by Alliance of Genome Resources, Apr 2022]

Vwf Products (1)

mRNA Protein Name
NM_011708.4 NP_035838.3 von Willebrand factor precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18281502 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within activation of blood coagulation via clotting cascade IDA
IDA: Inferred from direct assay
30573509 MGI
acts upstream of or within blood coagulation IMP
IMP: Inferred from mutant phenotype
9689113 MGI
acts upstream of or within cell-substrate adhesion IMP
IMP: Inferred from mutant phenotype
11071623 MGI
acts upstream of or within hemostasis IMP
IMP: Inferred from mutant phenotype
9689113 MGI
acts upstream of or within inflammatory response IDA
IDA: Inferred from direct assay
30573509 MGI
acts upstream of or within liver development IMP
IMP: Inferred from mutant phenotype
7854452 MGI
acts upstream of or within placenta development IMP
IMP: Inferred from mutant phenotype
7854452 MGI
NOT acts upstream of or within platelet activation IMP
IMP: Inferred from mutant phenotype
17380206 MGI
acts upstream of or within platelet activation IMP
IMP: Inferred from mutant phenotype
10930441 MGI
Cellular Component GO Annotation Evidence References Source
located in Weibel-Palade body IDA
IDA: Inferred from direct assay
30573509 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
8562500 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
30573509 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

von Willebrand factor

  • Von Willebrand factor homolog

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99227 Caplacizumab (His Tag) Inhibitor 99.83% Unkown

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-153999 Rondaptivon pegol Inhibitor 98.20% Phase 2
HY-147079A Egaptivon pegol sodium Inhibitor 92.75% Phase 2
HY-138019 SP-8008 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P5354 FRETS-VWF73 97.30% Unkown
HY-P5354A FRETS-VWF73 TFA 97.44% Unkown
HY-153999A Rondaptivon pegol sodium Inhibitor 98.20% Unkown
HY-138053 Ristocetin A sulfate 95.85% Unkown
HY-147079 Egaptivon pegol Inhibitor 92.75% Unkown
HY-RS15735 VWF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-153998 BT100 sodium Inhibitor / Unkown
HY-N19251 Sulfobacin B / Unkown
HY-RS17403 Vwf Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23858 Vwf Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990544 Anti-vWF Antibody 97.89% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vwf NCBI NCBI:7450