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Wt1 - WT1 transcription factor Gene

Also Known as Wt-1; D630046I19Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 22431

Summary

This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It plays an essential role in the normal development of the urogenital system, and the orthologous human gene is mutated in a small subset of patients with Wilm's tumors. Alternative splicing has been noted for this gene, however, the full-length nature of these variants is not known. The mRNA for this gene has been shown to initiate translation from non-AUG (CUG) and AUG translation start sites, resulting in different isoforms. [provided by RefSeq, Apr 2013]

Wt1 Products (1)

mRNA	Protein	Name
NM_144783.2	NP_659032.3	Wilms tumor protein homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	12609742	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	8530339	MGI
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	7585606	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9784496	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in RNA splicing	IDA IDA: Inferred from direct assay	9784496	MGI
acts upstream of or within Sertoli cell development	IMP IMP: Inferred from mutant phenotype	16418481	MGI
involved in adrenal cortex formation	IMP IMP: Inferred from mutant phenotype	17537799	MGI
involved in adrenal gland development	IMP IMP: Inferred from mutant phenotype	10101119	MGI
acts upstream of or within apoptotic process	IMP IMP: Inferred from mutant phenotype	16418481	MGI
involved in branching involved in ureteric bud morphogenesis	IMP IMP: Inferred from mutant phenotype	10101119	MGI
acts upstream of or within camera-type eye development	IMP IMP: Inferred from mutant phenotype	11889045	MGI
involved in cardiac muscle cell fate commitment	IMP IMP: Inferred from mutant phenotype	21654746	MGI
involved in diaphragm development	IMP IMP: Inferred from mutant phenotype	8395349	MGI
involved in epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	9927198	MGI
acts upstream of or within flagellated sperm motility	IMP IMP: Inferred from mutant phenotype	16418481	MGI
acts upstream of or within germ cell development	IMP IMP: Inferred from mutant phenotype	15063178	MGI
involved in glomerulus development	IMP IMP: Inferred from mutant phenotype	10101119	MGI
involved in gonad development	IMP IMP: Inferred from mutant phenotype	8395349	MGI
involved in heart development	IMP IMP: Inferred from mutant phenotype	10101119	MGI
involved in kidney development	IMP IMP: Inferred from mutant phenotype	11912180	MGI
involved in male genitalia development	IMP IMP: Inferred from mutant phenotype	10077614	MGI
acts upstream of or within male gonad development	IGI IGI: Inferred from genetic interaction	19457926	MGI
acts upstream of or within male gonad development	IMP IMP: Inferred from mutant phenotype	15063178	MGI
acts upstream of mesenchymal cell apoptotic process involved in metanephros development	IMP IMP: Inferred from mutant phenotype	8395349	MGI
involved in mesenchymal to epithelial transition	IMP IMP: Inferred from mutant phenotype	8395349	MGI
acts upstream of or within mesonephros development	IMP IMP: Inferred from mutant phenotype	9118800	MGI
involved in metanephric S-shaped body morphogenesis	IEP IEP: Inferred from expression pattern	18618131	MGI
involved in metanephric S-shaped body morphogenesis	IMP IMP: Inferred from mutant phenotype	10101119	MGI
involved in metanephric comma-shaped body morphogenesis	IEP IEP: Inferred from expression pattern	18618131	MGI
involved in metanephric mesenchyme development	IMP IMP: Inferred from mutant phenotype	8395349	MGI
acts upstream of or within metanephros development	IMP IMP: Inferred from mutant phenotype	10322633	MGI
involved in metanephros development	IMP IMP: Inferred from mutant phenotype	8395349	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	8530339	MGI
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	10101119	MGI
involved in negative regulation of female gonad development	IMP IMP: Inferred from mutant phenotype	19301398	MGI
acts upstream of or within negative regulation of mesenchymal cell apoptotic process involved in metanephros development	IMP IMP: Inferred from mutant phenotype	8395349	MGI
involved in negative regulation of metanephric glomerular mesangial cell proliferation	IMP IMP: Inferred from mutant phenotype	10077614	MGI
involved in podocyte development	IEP IEP: Inferred from expression pattern	18618131	MGI
involved in podocyte differentiation	IDA IDA: Inferred from direct assay	19050011	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	8530339	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	11912180	MGI
involved in positive regulation of heart growth	IMP IMP: Inferred from mutant phenotype	8395349	MGI
involved in positive regulation of male gonad development	IMP IMP: Inferred from mutant phenotype	19301398	MGI
involved in positive regulation of metanephric ureteric bud development	IMP IMP: Inferred from mutant phenotype	8395349	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21719793	MGI
involved in posterior mesonephric tubule development	IMP IMP: Inferred from mutant phenotype	9118800	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11889045	MGI
involved in regulation of animal organ formation	IMP IMP: Inferred from mutant phenotype	17537799	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	16418481	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12151099	MGI
acts upstream of or within seminiferous tubule development	IMP IMP: Inferred from mutant phenotype	16418481	MGI
acts upstream of or within sex determination	IMP IMP: Inferred from mutant phenotype	11509181	MGI
acts upstream of or within single fertilization	IMP IMP: Inferred from mutant phenotype	16418481	MGI
acts upstream of or within spermatogenesis	IMP IMP: Inferred from mutant phenotype	16418481	MGI
involved in thorax and anterior abdomen determination	IMP IMP: Inferred from mutant phenotype	8395349	MGI
involved in ureteric bud development	IMP IMP: Inferred from mutant phenotype	10322633	MGI
acts upstream of or within vasculogenesis	IMP IMP: Inferred from mutant phenotype	16264195	MGI
involved in visceral serous pericardium development	IMP IMP: Inferred from mutant phenotype	10101119	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	14678822	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12609742	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
Wilms tumor protein homolog	Wilms tumor 1 homolog

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14872	Tideglusib	Inhibitor	99.70%	Yes

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-104036	IDH-305	Inhibitor	99.15%	Phase 2
HY-P11084	WT1 126-134 peptide		98.89%	Phase 2

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122913	Borussertib	Inhibitor	99.18%	Unkown
HY-W143698	PDGFRα kinase inhibitor 2	Inhibitor	98.95%	Unkown
HY-RS17032	Wt1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-P11084A	WT1 126-134 peptide acetate		99.12%	Unkown
HY-RS15853	WT1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-120765	BRD2879	Inhibitor	/	Unkown
HY-RS23476	Wt1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99650	Grisnilimab	Inhibitor	99.43%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Wt1	NCBI	NCBI:7490