WT1 - WT1 transcription factor Gene

Also Known as GUD; AWT1; WAGR; WT-1; WT33; NPHS4; WIT-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7490

About WT1

Cytogenetic location: 11p13 Genomic coordinates (GRCh38): 11:32,387,775-32,435,539 (from NCBI)

This gene has 22 transcripts (splice variants), 204 orthologues, 4 paralogues and is associated with 130 phenotypes. Biased expression in endometrium (RPKM 27.6), testis (RPKM 17.6) and 4 other tissues.

Summary

This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Mar 2015]

WT1 Products (14)

mRNA	Protein	Name
NM_000378.6	NP_000369.4	Wilms tumor protein isoform A
NM_001198551.2	NP_001185480.1	Wilms tumor protein isoform E
NM_001198552.2	NP_001185481.1	Wilms tumor protein isoform F
NM_001367854.1	NP_001354783.1	Wilms tumor protein isoform G
NM_001407044.1	NP_001393973.1	Wilms tumor protein isoform H
NM_001407045.1	NP_001393974.1	Wilms tumor protein isoform I
NM_001407046.1	NP_001393975.1	Wilms tumor protein isoform J
NM_001407047.1	NP_001393976.1	Wilms tumor protein isoform K
NM_001407048.1	NP_001393977.1	Wilms tumor protein isoform L
NM_001407049.1	NP_001393978.1	Wilms tumor protein isoform M
NM_001407050.1	NP_001393979.1	Wilms tumor protein isoform N
NM_001407051.1	NP_001393980.1	Wilms tumor protein isoform O
NM_024424.5	NP_077742.3	Wilms tumor protein isoform B
NM_024426.6	NP_077744.4	Wilms tumor protein isoform D

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables C2H2 zinc finger domain binding	IPI IPI: Inferred from physical interaction	8119964	GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	23042785	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23042785	GOA
enables double-stranded methylated DNA binding	IDA IDA: Inferred from direct assay	25258363	GOA
enables hemi-methylated DNA-binding	IDA IDA: Inferred from direct assay	25258363	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7720589	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	1662794	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	1332065	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	15518539	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in adrenal gland development	IGI IGI: Inferred from genetic interaction	10101119	GOA
involved in branching involved in ureteric bud morphogenesis	IGI IGI: Inferred from genetic interaction	10101119	GOA
involved in cellular response to cAMP	IEP IEP: Inferred from expression pattern	15961562	GOA
involved in cellular response to gonadotropin stimulus	IDA IDA: Inferred from direct assay	15961562	GOA
involved in glomerular basement membrane development	IMP IMP: Inferred from mutant phenotype	19205749	GOA
involved in glomerulus development	IGI IGI: Inferred from genetic interaction	10101119	GOA
involved in heart development	IGI IGI: Inferred from genetic interaction	10101119	GOA
involved in kidney development	IGI IGI: Inferred from genetic interaction	11912180	GOA
involved in male gonad development	IEP IEP: Inferred from expression pattern	17848411	GOA
involved in metanephric S-shaped body morphogenesis	IGI IGI: Inferred from genetic interaction	10101119	GOA
involved in metanephric epithelium development	IEP IEP: Inferred from expression pattern	7856737	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	1332065	GOA
involved in negative regulation of apoptotic process	IGI IGI: Inferred from genetic interaction	10101119	GOA
involved in negative regulation of cell growth	IDA IDA: Inferred from direct assay	7588596	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	9553041	GOA
acts upstream of positive effect negative regulation of gene expression via chromosomal CpG island methylation	IMP IMP: Inferred from mutant phenotype	23042785	GOA
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	7585606	GOA
acts upstream of negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	23042785	GOA
involved in negative regulation of translation	IDA IDA: Inferred from direct assay	7588596	GOA
NOT involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	9815658	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	7588596	GOA
involved in positive regulation of DNA-templated transcription	IGI IGI: Inferred from genetic interaction	11912180	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	7588596	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23042785	GOA
involved in positive regulation of miRNA transcription	IMP IMP: Inferred from mutant phenotype	23042785	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	23042785	GOA
involved in sex determination	IDA IDA: Inferred from direct assay	9815658	GOA
involved in visceral serous pericardium development	IGI IGI: Inferred from genetic interaction	10101119	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nuclear speck	IDA IDA: Inferred from direct assay	9553041	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	15520190	GOA
located in nucleus	IDA IDA: Inferred from direct assay	1662794	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WT1 Protein Structure

WT1

zf-H2C2_2

zf-C2H2

0
100
200
300
400
517 a.a.

Protein Preferred Names	Protein Names
Wilms tumor protein	Wilms tumor 1

WT1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	WT1	P19544	KRT40	Homo sapiens	Q6A162	Y2H Array	31515488
Intra	WT1	P19544	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	25416956
Intra	WT1	P19544	KRTAP10-8	Homo sapiens	P60410	Y2H Array	25416956
Intra	WT1	P19544	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	25416956
Intra	WT1	P19544	TET2	Homo sapiens	Q6N021	Anti Tag CoIP	25601757
Intra	WT1	P19544	TET2	Homo sapiens	Q6N021	Anti Bait CoIP	25601757
Intra	WT1	P19544	DVL3	Homo sapiens	Q92997	Y2H Pooling	19447967

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant WT1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72261	Wilms tumor protein/WT1 Protein, Human (His-SUMO)	P19544 (M1-L449)	≥ 90%, as determined by reducing SDS-PAGE.

WT1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82532	Wilms Tumor Protein Antibody (YA2277)	WB, IHC-P, ICC/IF, FC	Human, Mouse
HY-P82532A	Wilms Tumor Protein Antibody (YA2277)(PBS only)	WB, IHC-P, ICC/IF, FC	Human, Mouse
HY-P84159	Wilms Tumor Protein Antibody (YA3856)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Monkey
HY-P84159A	Wilms Tumor Protein Antibody (YA3856)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Monkey
HY-P85931	Wilms Tumor Protein Antibody (YA5623)	IHC-P, WB, ICC/IF, ELISA	Human, Mouse, Rat, Pig
HY-P86440	Wilms Tumor Protein Antibody (YA6132)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
HY-P86923	Wilms Tumor Protein Antibody(YA6616)	mIHC	Mouse

Related Diseases

Diseases	Alias
Wilms Tumor 1	Nephroblastoma Wilms Tumor WT1 Wilms' Tumor Bilateral Wilms Tumor Wilms Tumor, Type 1 Wilms Tumor, Somatic Adult Nephroblastoma Wt1 Disorder Renal Embryonic Tumor Adult Kidney Wilms Tumor Childhood Kidney Wilms Tumor Nonanaplastic Kidney Wilms Tumor
Denys-Drash Syndrome	Drash Syndrome DDS Nephropathy, Wilms Tumor, And Genital Anomalies Wilms Tumor And Pseudohermaphroditism Wilms Tumor And Pseudo- Or True Hermaphroditism Nephropathy Associated With Male Pseudohermaphroditism And Wilms' Tumor Pseudohermaphroditism, Nephron Disorder And Wilms' Tumor Wilms Tumor-Dsd Syndrome Wilms Tumor-Disorder Of Sex Development Syndrome
Frasier Syndrome	FS
Meacham Syndrome	Meacham-Winn-Culler Syndrome Rhabdomyomatous Dysplasia-Cardiopathy-Genital Anomalies Syndrome MEACHS Meacham Winn Culler Syndrome
Nephrotic Syndrome, Type 4	NPHS4 Nephrotic Syndrome Type 4 Nephrotic Syndrome 4 Isolated Diffuse Mesangial Sclerosis
Mesothelioma, Malignant	Malignant Mesothelioma Pleural Mesothelioma MESOM Mesothelioma, Somatic Advanced Malignant Mesothelioma Asbestos-Related Malignant Mesothelioma Diffuse Malignant Mesothelioma Malignant Tumor Of Mesothelium Malignant Mesothelioma, Susceptibility To Mesothelioma Diffuse Malignant Mesothelioma Malignant Pleural Mesothelioma
Wilms Tumor, Aniridia, Genitourinary Anomalies, And Mental Retardation Syndrome	Wagr Syndrome 11p Partial Monosomy Syndrome Chromosome 11p13 Deletion Syndrome Wilms Tumor, Aniridia, Genitourinary Anomalies And Mental Retardation Syndrome 11p Deletion Syndrome Chromosome 11p Deletion Syndrome Wagr Complex Wilms Tumor-Aniridia-Genitourinary Anomalies-Intellectual Disability Syndrome Deletion 11p13 WAGR Wilms Tumor-Aniridia-Genitourinary Anomalies-Mental Retardation Syndrome Chromosome 11p Deletion 11p Deletion 11p Monosomy Deletion 11p Monosomy 11p Partial Monosomy 11p Agr Triad Wilms Tumor-Aniridia-Gonadoblastoma-Mental Retardation Syndrome Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental Retardation Syndrome Wagr Contiguous Gene Syndrome Wilms Tumor-Aniridia-Genital Anomalies-Retardation Syndrome Wilms Tumor-Aniridia-Genitourinary Anomalies-Mr Syndrome Del(11)(P13) Monosomy 11p13 Chromosome 11, Deletion 11p
Diffuse Mesangial Sclerosis	Familial Mesangial Sclerosis Mesangial Sclerosis, Diffuse Dms Diffuse Isolated Mesangial Sclerosis Isolated Diffuse Mesangial Sclerosis Nephrotic Syndrome, Early Onset With Diffuse Mesangial Sclerosis
Meacham Winn Culler Syndrome	Double Vagina, Cardiac, Pulmonary, And Other Genital Malformations With 46,Xy Karyotype
Aniridia 1	Aniridia Congenital Aniridia AN1 An Cataract With Late-Onset Corneal Dystrophy Aplasia Of Iris Absent Iris Irideremia Aniridia Ii, Formerly An2, Formerly An2 Aniridia Type Ii Aniridia, Type 1 An-1 Absence Of Iris Agenesis Of Iris Congenital Absence Of Iris Hereditary Aniridia Sporadic Aniridia
Desmoplastic Small Round Cell Tumor	Dsrct Desmoplastic Small Round-Cell Tumor Desmoplastic Small Round-Cell Neoplasm
Focal Segmental Glomerulosclerosis	Familial Idiopathic Steroid-Resistant Nephrotic Syndrome Focal Glomerulosclerosis Fsgs Segmental Glomerulosclerosis Glomerulosclerosis, Focal Segmental Fgs Focal Glomerular Sclerosis Familial Idiopathic Nephrotic Syndrome Focal Sclerosis With Hyalinosis Glomerulosclerosis, Focal Glomerulosclerosis Focal Glomerulosclerosis, Segmental, Focal Focal Segmental Glomerulosclerosis, Not Otherwise Specified
Genetic Steroid-Resistant Nephrotic Syndrome	Familial Idiopathic Steroid-Resistant Nephrotic Syndrome Genetic Srns Hereditary Steroid-Resistant Nephrotic Syndrome Familial Idiopathic Nephrotic Syndrome Nephrotic Syndrome, Steroid-Resistant, Autosomal Recessive Srn1
Disorder Of Sexual Development	Disorder Of Sex Development Disorders Of Sex Development Sex Development Disorder Sex Differentiation Disease Dsd Sex Differentiation Disorders
Gonadoblastoma	GBY
Adenomatoid Tumor	Adenomatoid Tumour Benign Localised Epithelial Mesothelioma Benign Localized Epithelial Mesothelioma
Acute Leukemia	Stem Cell Leukaemia Stem Cell Leukemia Acute Leukemias Acute Undifferentiated Leukemia Undifferentiated Leukemia Acute Leukaemia Of Unspecified Cell Type Without Mention Of Remission Blast Cell Leukaemia Blast Leukaemia Blastic Leukaemia Undifferentiated Leukaemia
Congenital Mesoblastic Nephroma	Mesoblastic Nephroma Nephroma, Mesoblastic
Clear Cell Sarcoma	Sarcoma, Clear Cell Adult Soft Part Clear Cell Sarcoma Clear Cell Sarcoma Of Soft Parts Malignant Melanoma Of Soft Parts Malignant Melanoma Of Soft Tissues Melanoma, Malignant, Of Soft Parts Sarcoma Clear Cell
46,Xy Sex Reversal	Swyer Syndrome Pure Gonadal Dysgenesis 46,Xy Gonadal Dysgenesis, Xy Female Type Gonadal Dysgenesis, 46,Xy 46,Xy Cgd 46,Xy Complete Gonadal Dysgenesis 46,Xy Pure Gonadal Dysgenesis 46 Xy Gonadal Dysgenesis 46, Xy Cgd 46, Xy Complete Gonadal Dysgenesis 46, Xy Pure Gonadal Dysgenesis Xy Pure Gonadal Dysgenesis Female With 46,Xy Karyotype Xy Females
Premature Menopause	Primary Ovarian Insufficiency Premature Ovarian Failure Hypergonadotropic Hypogonadism Premature Ovarian Insufficiency Menopause - Premature Menopause Praecox Menopause Premature Menopause, Premature Female Hypergonadotropic Hypogonadism Hypergonadotrophic Ovarian Failure Primary Female Hypogonadism Pof - [Premature Ovarian Failure] Ovarian Failure Ovarian Secretion Suppression Ovary Hyposecretion Ovary Secretion Deficiency Premature Menopause Nos
Nephrotic Syndrome	Finnish Congenital Nephrotic Syndrome Ns - [Nephrotic Syndrome] Nephrosis Syndrome Nephrosis Nos Glomerular Lesion Nephrosis
Benign Mesothelioma	Mesothelioma Benign Tumor Of Mesothelium Adenomatoid Tumor
Sex Cord-Gonadal Stromal Tumor	Sex Cord-Gonadal Stromal Tumour Sex Cord Stromal Tumour Sex Cord-Stromal Neoplasm Specialized Gonadal Neoplasm Specialized Gonadal Tumor Specialized Gonadal Tumour Sex Cord-Gonadal Stromal Tumors Sex Cord-Stromal Tumor Malignant Testicular Sex Cord-Stromal Tumor Sex Cord Stromal Tumor Of Testis
Pseudohermaphroditism	Indeterminate Sex And Pseudohermaphroditism
Septate Vagina	Doubling Of Vagina Duplication Of Vagina Congenital Duplication Of Vagina Double Vagina Extra Vagina Supernumerary Vagina Vaginal Septum Congenital Septate Vagina Bipartite Vagina Accessory Vagina
Hypospadias	Hypospadias Familial Familial Hypospadias
Nephroma	Benign Nephroma
46,Xy Partial Gonadal Dysgenesis	46,Xy Pgd 46,Xy Partial Testicular Dysgenesis
Leukemia	Leukemias Leukaemia, Unspecified, Without Mention Of Remission Aleukemic Leukaemia Chronic Leukaemia Subacute Leukaemia Leukaemia Disorder Leukaemia Nos
Ewing Sarcoma	Neuroepithelioma Ewing'S Tumor Primitive Neuroectodermal Tumor Ewings Sarcoma Ewing'S Sarcoma Peripheral Neuroepithelioma ES Ewings Sarcoma-Primitive Neuroectodermal Tumor Localized Peripheral Primitive Neuroectodermal Tumor Peripheral Primitive Neuroectodermal Tumor Ewing Tumor Sarcoma, Ewing'S Ewing Family Of Tumors Extraosseous Ewing Tumor Askin Tumor Ewing'S Family Localized Tumor Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing Sarcoma Localized Ewing'S Sarcoma Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing'S Tumor Pnet Of Thoracopulmonary Region Tumor Of The Ewing Family Skeletal Ewing Sarcoma Osseous Ewing Sarcoma Ppnet Peripheral Pnet Extraskeletal Ewing Sarcoma Eoe Extraosseous Ewing Sarcoma Extraskeletal Ewing Tumor Esft Ewing Sarcoma Family Of Tumors Pne Pnet Pnet Of The Chest Wall Sarcoma, Ewing Neuroectodermal Tumors, Primitive, Peripheral Neuroectodermal Tumor, Primitive Disorder Of Eye Askin'S Tumor Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor Neuroepithelioma, Peripheral
Myelodysplastic Syndrome	Myelodysplastic Syndromes Myelodysplasia MDS Myelodysplastic Syndrome Included Myelodysplastic Syndrome, Susceptibility To, Included Myelodysplastic Syndrome, Somatic Myelodysplastic Syndrome, Susceptibility To
Myeloid Leukemia	Myeloid Leukaemia Leukaemia Myelogenous Leukemia Myelogenous Myeloid Granulocytic Leukaemia Myeloid Granulocytic Leukemia Non-Lymphocytic Leukemia Leukemia, Myeloid Granulocytic Leukaemia Myelogenous Leukaemia Myeloid Leukaemia, Unspecified, Without Mention Of Remission
Rhabdoid Cancer	Rhabdoid Tumor Malignant Rhabdoid Tumor Malignant Rhabdoid Tumour Rhabdoid Sarcoma Rhabdoid Tumor Predisposition Syndrome 1 Rhabdoid Tumor Predisposition Syndrome 2 Atypical Teratoid Rhabdoid Tumor Brain Tumor, Posterior Fossa, Of Infancy, Familial Atypical Teratoid/Rhabdoid Tumor
Hereditary Wilms' Tumor	Hereditary Wilms Tumor Hereditary Wilms Tumour Hereditary Wilms' Tumour Wt1
Peritoneum Cancer	Peritoneal Neoplasm Cancer Of Peritoneum Malignant Tumor Of Peritoneum Peritoneal Neoplasms
Gonadal Dysgenesis	Gonadal Dysgenesis Syndrome Turner Syndrome
Testicular Gonadoblastoma
Sarcoma	Connective And Soft Tissue Neoplasm Tumor Of Soft Tissue And Skeleton Sarcomas Sarcoma - Category
Sertoli-Leydig Cell Tumor	Sertoli-Leydig Cell Tumors Androblastoma Of Ovary Arrhenoblastoma Arrhenoblastoma Of Ovary Sertoli-Leydig Cell Tumor Of The Ovary Sertoli-Leydig Cell Tumor Of Intermediate Differentiation Sertoli-Leydig Cell Tumor Of Ovary
Sarcomatoid Mesothelioma	Malignant Fibrous Mesothelioma Spindled Mesothelioma
Sertoli Cell Tumor	Tubular Androblastoma
Leiomyosarcoma	Leiomyosarcomas
Chronic Leukemia	Adult Chronic Leukemia Cll Cml
Wilms Tumor 5	Wilms Tumor WT5 Wilms Tumor Susceptibility-5 Wilms Tumor And Radial Bilateral Aplasia Nephroblastoma Wilms' Tumor Wilms Tumor, Susceptibility To Wtsl Bilateral Radial Aplasia With Wilms Tumor Embryonal Adenosarcoma Embryonal Nephroma Kidney Wilms Tumor Kidney, Adenomyosarcoma, Embryonal Kidney, Carcinosarcoma, Embryonal Kidney, Embryoma Kidney, Embryonal Mixed Tumor Nephroma Renal Adenosarcoma Renal Cancer, Wilms Renal Wilms Tumor Tumor, Wilms Hereditary Susceptibility To Wilms Tumor 5
Kidney Disease	Renal Failure Kidney Failure Kidney Diseases Nephropathy Abnormality Of The Kidney Impaired Renal Function Disease Renal Anomaly Kidney Dysfunction Renal Disease Nephropathies Renal Failure Adverse Event Abnormal Renal Function
Dopamine Beta-Hydroxylase Deficiency	Noradrenaline Deficiency Norepinephrine Deficiency Dopamine Beta Hydroxylase Deficiency Congenital Dopamine Beta-Hydroxylase Deficiency Dopamine Beta-Hydroxylase Deficiency, Congenital Dopamine Β-Hydroxylase Dbh Deficiency
Nephrotic Syndrome, Type 1	Finnish Congenital Nephrosis NPHS1 Cnf Finnish Congenital Nephrotic Syndrome Nephrotic Syndrome Type 1 Nephrosis, Congenital Congenital Nephrotic Syndrome Nephrotic Syndrome, Congenital Congenital Nephrotic Syndrome Finnish Type Congenital Nephrotic Syndrome 1 Nephrosis 1, Congenital, Finnish Type Congenital Nephrotic Syndrome, Finnish Type Nephrotic Syndrome 1 Congenital Nephrotic Syndrome Of The Finnish Type
Ovarian Brenner Tumor	Benign Ovarian Brenner Tumor Brenner Tumor Benign Ovarian Brenner Tumour Ovarian Brenner Tumour Brenner Tumor Of Ovary Benign Brenner Tumor
Epithelial Predominant Wilms' Tumor	Epithelial Predominant Kidney Adenosarcoma Epithelial Predominant Renal Wilms Tumor Epithelial Predominant Renal Wilms Tumour Epithelial Predominant Wilms' Tumour
Nephrogenic Adenofibroma	Metanephric Adenofibroma
Intellectual Developmental Disorder, X-Linked, Syndromic, Wilson-Turner Type	Wilson-Turner Syndrome WTS Mrxs6 X-Linked Intellectual Disability-Gynecomastia-Obesity Syndrome Mrxswt Wilson-Turner X-Linked Mental Retardation Syndrome Mental Retardation, X-Linked, Syndromic 6 Mental Retardation, X-Linked, With Gynecomastia And Obesity Intellectual Disability, X-Linked, Syndromic 6 Intellectual Disability, X-Linked, With Gynecomastia And Obesity Wilson Turner Intellectual Disability Syndrome X-Linked Intellectual Disability - Gynecomastia - Obesity
Iris Disease	Iris Diseases
Metanephric Adenoma
Endosalpingiosis
Renal Adenoma	Renal Cell Adenoma
Thymic Carcinoma	Malignant Thymoma Thymoma, Malignant
Peritoneal Mesothelioma	Malignant Mesothelioma Of Peritoneum Advanced Malignant Mesothelioma Of Peritoneum Advanced Malignant Peritoneal Mesothelioma Advanced Peritoneal Malignant Mesothelioma
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Rhabdomyosarcoma 2	Alveolar Rhabdomyosarcoma Rhabdomyosarcoma, Alveolar Rhabdomyosarcoma Alveolar RMS2 Rmsa Rhabdomyosarcoma 2, Alveolar Alveolar Childhood Rhabdomyosarcoma Arms Rhabdomyosarcoma, Type 2
Hobnail Hemangioma
Asbestosis	Idiopathic Interstitial Pneumonitis - From Asbestos Exposure Pulmonary Fibrosis - From Asbestos Exposure
Cryptorchidism, Unilateral Or Bilateral	Cryptorchidism Undescended Testicle Undescended Testis Cryptorchism Undescended Testicles CRYPTO Impaired Testicular Descent Cryptosporidiosis Retained Testis Unilateral Cryptorchidism Unilateral Undescended Testis Nondescent Unilateral Testicle Unilateral Cryptorchism Ectopic Testis, Unilateral Bilateral Cryptorchidism Bilateral Cryptorchism Bilateral Nondescent Testicle Bilateral Undescended Testes Bilateral Ectopic Testes
Carcinosarcoma	Mixed Tumor, Mullerian Malignant Mixed Mesodermal Tumor Malignant Mixed Mullerian Tumor Mmmt Mixed Tumor, Mesodermal Mesodermal Mixed Tumor Mixed Mesodermal Tumor Mullerian Mixed Tumor Mixed Mullerian Tumor Malignant Mixed Müllerian Tumor Mixed Müllerian Tumor Mixed Tumor Mullerian Mixed Tumor, Not Otherwise Specified
Hematologic Cancer	Hematologic Neoplasm Hematologic Neoplasms Hematologic Malignancies Blood Cancer Hematologic Malignancy Hematological Tumors Hematopoietic And Lymphoid System Tumor Hematopoietic Cancer Hematopoietic Neoplasm Hematopoietic Tumors Malignant Hematopoietic Neoplasm Liquid Tumor Hematopoietic Neoplasms
Fallopian Tube Carcinoma	Fallopian Tube Cancer Cancer Of The Fallopian Tube Carcinoma Of Fallopian Tube Neoplasm Of Fallopian Tube Fallopian Tube Neoplasms Fallopian Tube Ca Fallopian Tube Neoplasm Malignant Neoplasm Of Uterine Tube Malignant Tumor Of Fallopian Tube Malignant Tumour Of Fallopian Tube Tumor Of The Fallopian Tube Tumor, Fallopian Tube, Malignant Malignant Tumor Of Fallopian Tubes Cancer Of Fallopian Tubes Malignant Tubal Tumor Tubal Cancer Malignant Neoplasm Of Fallopian Tube Primary Malignant Neoplasm Of Fallopian Tube Cancer Of The Oviduct
Malignant Biphasic Mesothelioma	Mesothelioma, Biphasic, Malignant Mixed Mesothelioma
Sarcomatosis
Peritoneal Serous Adenocarcinoma	Primary Peritoneal Serous Adenocarcinoma
Neurofibroma Of The Heart	Neurofibroma Of Heart
Pericardium Cancer	Malignant Neoplasm Of Pericardium Malignant Tumor Of Pericardium Pericardial Tumor Neoplasm Of Pericardium
Pericardial Mesothelioma	Malignant Mesothelioma Of Pericardium Malignant Pericardial Mesothelioma
Kidney Cortex Disease
Fallopian Tube Squamous Cell Carcinoma	Squamous Cell Carcinoma Of The Fallopian Tube
Ovarian Sex-Cord Stromal Tumor	Ovarian Sex Cord Tumor With Annular Tubules Ovarian Sex Cord-Stromal Tumor Stromal Tumor Of Ovary
Dysgerminoma
Familial Nephrotic Syndrome	Congenital Nephrotic Syndrome Nephrosis, Congenital Finnish Congenital Nephrotic Syndrome
Diaphragmatic Hernia, Congenital	Congenital Diaphragmatic Hernia Diaphragmatic Hernia Cdh Congenital Diaphragmatic Defect Hernia, Diaphragmatic Dih Hernia, Congenital Diaphragmatic Hcd Diaphragmatic Defect, Congenital Diaphragm, Unilateral Agenesis Of Hemidiaphragm, Agenesis Of Diaphragmatic Hernia 1 Agenesis Of Hemidiaphragm Unilateral Agenesis Of Diaphragm Hernia Diaphragmatic Hernia Diaphragmatic Congenital Hernia, Diaphragmatic, Type 1 Hiatus Hernia Oesophageal Hiatus Hernia Paraoesophageal Hernia Sliding Hiatus Hernia Congenital Diaphragm Hernia Congenital Diaphragm Defect With Hernia Gross Congenital Diaphragm Defect
Leukemia, Chronic Myeloid	Chronic Myeloid Leukemia Chronic Myelogenous Leukemia CML Chronic Granulocytic Leukemia Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib Chronic Myeloid Leukaemia Chronic Granulocytic Leukaemia Chronic Myelogenous Leukaemia Myeloid Leukemia, Chronic Leukemia, Chronic Myelogenous Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic Cml - Chronic Myelogenous Leukemia Cgl Chronic Myelocytic Leukemia Leukemia, Chronic Myeloid, Atypical ACML Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Myeloid Leukemia Chronic Leukemia, Myeloid, Chronic Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Cml- [Chronic Myeloid Leukaemia] Cgl - [Chronic Granulocytic Leukaemia] Chronic Myelocytic Leukaemia
Cystadenofibroma
Peritoneal Serous Papillary Adenocarcinoma	Primary Serous Papillary Carcinoma Of Peritoneum
Ovarian Seromucinous Carcinoma	Mixed Epithelial Carcinoma Of Ovary Ovary Mixed Epithelial Carcinoma
Spermatic Cord Cancer	Malignant Tumor Of Spermatic Cord Malignant Tumor Of The Spermatic Cord Spermatic Cord Ca Malignant Neoplasm Of Spermatic Cord
Kidney Rhabdoid Cancer	Rhabdoid Tumor Of The Kidney Kidney Rhabdoid Tumor Renal Rhabdoid Tumor
Serous Cystadenocarcinoma	Serous Adenocarcinoma Cystadenocarcinoma, Serous Serous Carcinoma Cystadenocarcinoma Serous
Embryonal Rhabdomyosarcoma	Rhabdomyosarcoma, Embryonal Rhabdomyosarcoma Embryonal Botryoid Rhabdomyosarcoma Erms Spindle Cell Rhabdomyosarcomas
Kidney Cancer	Renal Cancer Renal Carcinoma Kidney Neoplasm Malignant Neoplasm Of Kidney Except Pelvis Malignant Tumour Of Kidney Kidney Neoplasms Cancer, Kidney Cancer, Renal Malignant Neoplasm Of Kidney Renal Cell Carcinoma
Beckwith-Wiedemann Syndrome	Wiedemann-Beckwith Syndrome BWS Exomphalos-Macroglossia-Gigantism Syndrome Emg Syndrome Beckwith-Wiedemann Syndrome Due To Cdkn1c Mutation Emg Abnormality Wbs Exomphalos Macroglossia Gigantism Syndrome Beckwith-Wiedemann Syndrome Due To Nsd1 Mutation Macroglossia Exomphalos Gigantism
Angiokeratoma Of Fordyce	Fordyce Angiokeratoma Fordyce'S Spot Fordyce-Type Angiokeratoma Of Scrotum
Ovarian Mesodermal Adenosarcoma	Ovarian Mullerian Adenosarcoma Ovarian Adenosarcoma
Fallopian Tube Adenocarcinoma	Adenocarcinoma Of The Fallopian Tube
Ovarian Benign Neoplasm	Benign Ovarian Neoplasm
Syndromic X-Linked Intellectual Disability	X-Linked Syndromic Intellectual Disability
Kidney Sarcoma	Renal Sarcoma Sarcoma Of Kidney
Juvenile Type Testicular Granulosa Cell Tumor	Juvenile Granulosa Cell Tumor Juvenile Granulosa Cell Tumour Juvenile Type Granulosa Cell Neoplasm Juvenile Type Granulosa Cell Tumor Juvenile Type Granulosa Cell Tumour Juvenile Type Testicular Granulosa Cell Tumour
Ovarian Wilms' Cancer	Ovarian Wilms' Tumor
Kidney Benign Neoplasm	Renal And Ureteral Tumor Benign Kidney Neoplasm
Cervical Serous Adenocarcinoma
Hypereosinophilic Syndrome, Idiopathic	Idiopathic Hypereosinophilic Syndrome Hypereosinophilic Syndrome, Idiopathic, Resistant To Imatinib HES
Testicular Granulosa Cell Tumor	Granulosa Cell Tumor Of Testis Granulosa Cell Tumour Of Testis Testicular Granulosa Cell Tumour
Ovarian Large-Cell Neuroendocrine Carcinoma	Non-Small-Cell Type Neuroendocrine Carcinoma Of Ovary Ovarian Large Cell Neuroendocrine Carcinoma
Cauda Equina Neoplasm	Tumor Of The Cauda Equina Neoplasm Of Cauda Equina
Botryoid Rhabdomyosarcoma	Sarcoma Botryoides Botryoid Sarcoma Botryoid-Type Embryonal Rhabdomyosarcoma
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Angioma Serpiginosum	Angioma Serpiginosum Of Skin Angioma Serpiginosum, X-Linked
Pierson Syndrome	Microcoria-Congenital Nephrotic Syndrome Microcoria-Congenital Nephrosis Syndrome PIERS Microcoria - Congenital Nephrosis Microcoria - Congenital Nephrotic Syndrome PIERSS
Hemihyperplasia, Isolated	Hemihypertrophy Hemihyperplasia Isolated Hemihyperplasia IH Hhp Hemihypertrophy, Isolated Hemi 3 Syndrome Hemicorporal Hypertrophy Isolated Hemihypertrophy Hemi-3 Syndrome
46,Xy Sex Reversal 2	Dosage-Sensitive Sex Reversal Dss SRXY2 46,Xy Sex Reversal, Dax1-Related 46xy Sex Reversal 2, Dosage-Sensitive 46,Xy Sex Reversal Dax1-Related
Papillary Serous Adenocarcinoma	Micropapillary Serous Carcinoma Serous Surface Papillary Carcinoma Papillary Serous Carcinoma Papillary Serous Cystadenocarcinoma
Renal Wilms' Tumor	Nonanaplastic Renal Wilm'S Tumor Nonanaplastic Renal Wilm'S Tumour Nonanaplastic Renal Wilms Tumor Renal Wilms' Tumour
Oral Tuberculosis	Tuberculosis, Oral
Childhood Acute Myeloid Leukemia	Childhood Acute Myeloid Leukaemia Paediatric Acute Myeloid Leukaemia Pediatric Acute Myeloid Leukemia
Adenofibroma
Ovarian Small Cell Carcinoma	Small Cell Carcinoma Of The Ovary Scco Small Cell Ovarian Carcinoma
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Epididymis Adenocarcinoma	Adenocarcinoma Of The Epididymis
46,Xx Sex Reversal	46,Xx Testicular Disorder Of Sex Development 46,Xx Testicular Dsd De La Chapelle Syndrome Srxx Xx, Male Syndrome 46, Xx Testicular Disorders Of Sex Development
Epididymis Cancer	Malignant Tumor Of Epididymis Malignant Epididymal Tumor Malignant Neoplasm Of Epididymis Neoplasm Of Epididymis
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Fallopian Tube Serous Adenocarcinoma
Small Intestinal Sarcoma	Sarcoma Of The Small Intestine
Myelofibrosis	Primary Myelofibrosis Agnogenic Myeloid Metaplasia Idiopathic Myelofibrosis Myeloid Metaplasia Myelofibrosis With Myeloid Metaplasia Osteomyelofibrosis Megakaryocytic Myelosclerosis Myelosclerosis Chronic Idiopathic Myelofibrosis Myelofibrosis, Idiopathic Myelofibrosis With Myeloid Metaplasia, Somatic Myelofibrosis, Somatic Aleukemic Myelosis Bone Marrow Fibrosis MYELOF MMM Agnogenic Myeloid Metaplasia With Myelofibrosis Ammm Myelosclerosis With Myeloid Metaplasia Myelofibrosis Nos
Ovarian Mucinous Neoplasm	Ovarian Mucinous Tumor Malignant Ovarian Mucinous Neoplasm Mucinous Tumor Of Ovary Malignant Ovarian Mucinous Tumor
Heart Cancer	Malignant Neoplasm Of Heart Heart Neoplasm Cardiac Tumor Malignant Cardiac Tumor Tumour Of Heart Heart Neoplasms Cardiac Carcinoma
Endometrioid Ovary Carcinoma	Endometrioid Carcinoma Of Ovary Endometrioid Carcinoma Ovary Ovarian Endometrioid Carcinoma Malignant Ovarian Endometrioid Tumor Ovarian Endometrioid Tumor
Hematocele Of Tunica Vaginalis Testis	Hematocele Male Hematocele
Fallopian Tube Carcinosarcoma	Fallopian Tube Malignant Mixed Mesodermal Tumor Fallopian Tube Malignant Mixed Mullerian Tumor
Persistent Mullerian Duct Syndrome	Persistent Müllerian Duct Syndrome Pmds Persistent Oviduct Syndrome Persistent Muellerian Duct Syndrome Female Genital Ducts In Otherwise Normal Male Hernia Uteri Inguinale Persistent Mullerian Duct Syndrome, Types 1 And 2 Persistent Mullerian Derivatives
Ovary Serous Adenocarcinoma	Malignant Ovarian Serous Tumor Serous Carcinoma Of Ovary
Microinvasive Cervical Squamous Cell Carcinoma	Early Invasive Cervical Squamous Cell Carcinoma
Epididymal Neoplasm	Neoplasm Of Epididymis
Synovium Cancer	Malignant Tumor Of Synovium Synovial Neoplasm
Ovarian Mixed Germ Cell Neoplasm	Mixed Germ Cell Tumor Of Ovary Ovarian Mixed Germ Cell Tumor
Galloway-Mowat Syndrome 1	Galloway Syndrome Nephrosis-Neuronal Dysmigration Syndrome Nephrosis-Microcephaly Syndrome Camos Scar5 GAMOS1 Microcephaly, Hiatal Hernia, And Nephrotic Syndrome Microcephaly, Hiatal Hernia And Nephrotic Syndrome Cerebellar Ataxia With Mental Retardation, Optic Atrophy, And Skin Abnormalities Spinocerebellar Ataxia, Autosomal Recessive 5, Formerly Scar5, Formerly Spinocerebellar Ataxia Autosomal Recessive 5 Cerebellar Ataxia With Intellectual Disability Optic Atrophy And Skin Abnormalities Camos Syndrome Cerebellar Ataxia-Intellectual Disability-Optic Atrophy-Skin Abnormalities Syndrome Galloway-Mowat Syndrome Spinocerebellar Ataxia, Autosomal Recessive, 5 Galloway Mowat Syndrome Spinocerebellar Ataxia, Autosomal Recessive 5
Spindle Cell Hemangioma	Sch Spindle Cell Hemangioendothelioma
Chronic Kidney Disease	Chronic Renal Disease Chronic Kidney Failure Ckd Chronic Renal Failure Kidney Failure, Chronic Chronic Renal Failure Syndrome Crf Renal Failure - Chronic Renal Failure Chronic Chronic Kidney Diseases Chronic Kidney Disease Stage 5 Ckd - [Chronic Kidney Disease] Crf - [Chronic Renal Failure] Chronic Kidney Impairment Chronic Renal Impairment Chronic Kidney Shutdown Chronic Hypoxic Kidney Failure Chronic Kidney Collapse Chronic Renal Insufficiency Chronic Kidney Toxaemia Chronic Kidney Hypofunction Chronic Renal Suppression Chronic Renal Failure, Stage 5 Ckd - [Chronic Kidney Disease] Stage 5 End Stage Kidney Failure End Stage Renal Failure End Stage Kidney Disease End Stage Renal Disease End Stage Chronic Renal Failure Esrf - [End Stage Renal Failure] Esrd - [End Stage Renal Diseases] Egfr - [Estimated Glomerular Filtration Rate] < 15 Ml/Min/1.73m²
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Bladder Clear Cell Adenocarcinoma	Bladder Mesonephric Adenocarcinoma Clear Cell Adenocarcinoma Of Bladder
Hepatoblastoma
Endometrial Stromal Tumor	Endometrial Stromal Neoplasm Endometrial Stromal Tumors
Lipoid Nephrosis	Minimal Change Disease Minimal Change Glomerulonephritis Nephrotic Syndrome With Lesion Of Minimal Change Glomerulonephritis Nephrotic Syndrome With Lesion Of Minimal Change Nephrotic Syndrome Idiopathic Minimal Change Nephrotic Syndrome Mcns Minimal Change Glomerulopathy Minimal Change Nephrotic Syndrome Nephrotic Syndrome Minimal Change Nephrosis, Lipoid Glomerulonephritis, Minimal Change Nephrotic Syndrome, Minimal Change
Myxoid Chondrosarcoma
Renal Hypoplasia
Mixed Cell Type Cancer	Malignant Mixed Neoplasm Malignant Mixed Tumor Mixed Neoplasm Mixed Tumor, Malignant Malignant Mixed Cancer Mixed Tumor Malignant Mixed Tumor, Not Otherwise Specified Mixed Salivary Gland Tumor Mixed Tumor, Not Otherwise Specified
Syndromic Intellectual Disability
Endometrial Serous Adenocarcinoma	Uterine Serous Carcinoma Uterine Corpus Serous Adenocarcinoma Uterine Papillary Serous Carcinoma
Angiokeratoma	Angiokeratoma Of Skin Cutaneous Angiokeratoma Skin Angiokeratoma
Thymus Sarcomatoid Carcinoma	Thymic Carcinosarcoma Thymic Sarcomatoid Carcinoma
Ovarian Serous Carcinoma	Ovarian Serous Adenocarcinoma
Hydrocele	Testicular Hydrocele
Ovarian Carcinosarcoma	Ovarian Malignant Mixed Mullerian Tumor Mmmt Of The Ovary Malignant Mixed Mullerian Tumor Of The Ovary Ovarian Malignant Mixed Epithelial Mesenchymal Tumor Ovarian Malignant Mesodermal Mixed Tumor Ovarian Mmmt Malignant Mixed Müllerian Tumor Of The Ovary Ovarian Malignant Mixed Müllerian Tumor Carcinosarcoma Of Ovary
Skin Hemangioma	Angioma Of The Skin Angiomatous Naevus Of Skin Hemangioma Of Skin
Childhood Leukemia
Prostate Leiomyoma	Prostatic Leiomyoma
Diaphragm Disease	Abnormality Of The Diaphragm Disease Of Diaphragm Diaphragmatic Disorder Disorder Of Diaphragm
Papillary Cystadenocarcinoma	Cystadenocarcinoma, Papillary
Cystadenocarcinoma
Ovarian Germ Cell Cancer	Ovarian Germ Cell Tumor Malignant Germ Cell Tumor Of Ovary Germ Cell Neoplasm Of Ovary Germ Cell Tumor Of Ovary Mogct Malignant Ovarian Germ Cell Tumor Malignant Ovarian Germ Cell Neoplasm
Pleural Cancer	Pleural Neoplasms Neoplasm Of Pleura Pleural Tumor Malignant Tumor Of Pleura Pleural Cavity Cancer Primary Malignant Neoplasm Of Parietal Pleura Primary Malignant Neoplasm Of Pleura Primary Malignant Neoplasm Of Visceral Pleura
Gillespie Syndrome	GLSP Aniridia, Cerebellar Ataxia And Mental Deficiency Aniridia Cerebellar Ataxia Mental Deficiency Aniridia, Cerebellar Ataxia, And Mental Retardation Aniridia-Cerebellar Ataxia-Intellectual Disability Syndrome Aniridia-Cerebellar Ataxia-Intellectual Disability Aniridia-Cerebellar Ataxia-Mental Deficiency Partial Aniridia-Cerebellar Ataxia-Oligophrenia Aniridia, Cerebellar Ataxia, And Intellectual Disability
Kidney Clear Cell Sarcoma	Clear Cell Sarcoma Of Kidney Childhood Kidney Clear Cell Sarcoma Renal Clear Cell Sarcoma Ccsk Clear Cell Sarcoma Of The Kidney
Malignant Teratoma	Immature Teratoma Malignant Extragonadal Teratoma Primary Malignant Extragonadal Teratoma Teratoma, Malignant, Nos Teratoma, Malignant Immature Extragonadal Teratoma
Female Reproductive Endometrioid Cancer	Endometrioid Tumor Endometrioid Neoplasm Female Reproductive Endometrioid Neoplasm
Testicular Fibroma
Cervical Adenosarcoma	Cervical Muellerian Adenosarcoma Cervical Mullerian Adenosarcoma
Renal Hypodysplasia/Aplasia 1	Renal Agenesis Renal Adysplasia Renal Aplasia RHDA1 Hereditary Renal Aplasia Hra Hereditary Urogenital Adysplasia Hypodysplasia/Aplasia, Renal, Type 1 Congenital Absence Of Kidneys Syndrome Congenital Absence Of Kidney Aplastic Kidney
Ovarian Clear Cell Carcinoma	Clear-Cell Ovarian Carcinoma
Muscle Cancer	Myosarcoma Malignant Neoplasm Of Muscle Malignant Tumor Of Muscle Malignant Tumor Of The Muscle Muscle Neoplasms Myomatous Neoplasm
Skeletal Muscle Cancer	Malignant Tumor Of Skeletal Muscle Skeletal Muscle Neoplasm
Angiokeratoma Circumscriptum
Sarcoma, Synovial	Synovial Sarcoma Synovialosarcoma Synovial Cell Sarcoma Sarcoma Synovial
Endometrial Stromal Sarcoma	Ess Endometrial Stromal Sarcoma, High Grade Undifferentiated Endometrial Sarcoma Stromal Sarcoma Of The Corpus Uteri Sarcoma Endometrial Stromal Sarcoma, Endometrial Stromal Undifferentiated Stromal Sarcoma
Ovary Adenocarcinoma	Ovarian Adenocarcinoma Adenocarcinoma Of The Ovary Ovarian Adenoacanthoma Adenocarcinoma Of Ovary
Malignant Ovarian Surface Epithelial-Stromal Neoplasm	Malignant Ovarian Surface Epithelial-Stromal Tumor
46,Xy Sex Reversal 9	SRXY9 46,Xy Sex Reversal, Zfpm2-Related 46xy Sex Reversal 9
Rhabdomyosarcoma
Chondrosarcoma, Extraskeletal Myxoid	Extraskeletal Myxoid Chondrosarcoma Emc Myxoid Extraosseous Chondrosarcoma
Liver Leiomyosarcoma	Leiomyosarcoma Of The Liver
Acute Myeloid Leukemia With Bcr-Abl1	Acute Myeleoid Leukemia With Bcr-Abl1
Inguinal Hernia	Hernia Inguinal Hernia, Inguinal Inguinal Hernias Bubonocele Indirect Inguinal Hernia Direct Inguinal Hernia Oblique Inguinal Hernia Scrotal Hernia Ih - [Inguinal Hernia]
Galloway-Mowat Syndrome	Galloway Mowat Syndrome Galloway Syndrome Hiatal Hernia-Microcephaly-Nephrosis, Galloway Type Microcephaly Nephrosis Syndrome Microcephaly, Hiatal Hernia, And Nephrotic Syndrome Nephrosis Neuronal Dysmigration Syndrome Microcephaly-Hiatus Hernia-Nephrotic Syndrome Nephrosis-Neuronal Dysmigration Syndrome
Uveal Disease	Uveal Diseases
Alport Syndrome	Hereditary Nephritis Alport Syndrome, X-Linked Hemorrhagic Hereditary Nephritis Congenital Hereditary Hematuria Hemorrhagic Familial Nephritis Familial Nephritis Thin Basement Membrane Disease Thin Basement Membrane Nephropathy Hematuria-Nephropathy-Deafness Syndrome Hematuric Hereditary Nephritis Hereditary Familial Congenital Hemorrhagic Nephritis Hereditary Hematuria Syndrome Hereditary Interstitial Pyelonephritis Alport Deafness-Nephropathy Alport Hearing Loss-Nephropathy Alports Syndrome Nephritis, Hereditary
Chromosomal Deletion Syndrome
Ovarian Gonadoblastoma
Cakut	Renal Or Urinary Tract Malformation Congenital Anomalies Of Kidney And Urinary Tract Congenital Anomaly Of Kidney And Urinary Tract Congenital Anomalies Of The Kidney And Urinary Tract Kidney And Urinary Tract, Anomalies, Congenital Renal Hypodysplasia, Nonsyndromic, 1
Ovarian Serous Cystadenofibroma
Parkinson Disease 17	PARK17 Parkinson'S Disease 17 Autosomal Dominant Parkinson Disease 17 Parkinson Disease, Type 17
Benign Peritoneal Mesothelioma	Mesothelioma Of Peritoneum Benign Neoplasm Of Mesothelial Tissue Of Peritoneum
Epithelioid Cell Synovial Sarcoma	Synovial Sarcoma, Epithelioid Cell Epithelioid Synovial Sarcoma
Renal Cell Carcinoma, Papillary, 1	Papillary Renal Cell Carcinoma Hereditary Papillary Renal Cell Carcinoma Papillary Renal Cell Carcinoma, Sporadic Papillary Renal Cell Adenocarcinoma RCCP RCCP1 Renal Cell Carcinoma, Papillary Renal Cell Carcinoma, Papillary, 1, Familial And Somatic Chromophil Carcinoma Of Kidney Papillary Kidney Carcinoma Sporadic Papillary Renal Cell Carcinoma Chromophil Renal Cell Carcinoma Papillary Renal Carcinoma, Malignant - Papillary Renal Cell Carcinoma, Bilateral - Papillary Renal Cell Carcinoma, Familial - Papillary Renal Cell Carcinoma, Multiple - Papillary Renal Cell Carcinoma, Sporadic - Renal Adenocarcinoma Chromophil Rcc Hprcc Renal Cell Carcinoma Papillary Chromophilic Renal Cell Carcinoma Prcc Carcinoma, Renal Cell, Papillary, Type 1 Type 1 Papillary Renal Cell Carcinoma Renal Cell Carcinoma Hereditary Papillary Renal Carcinoma
Spermatogenic Failure	Azoospermia Spgf Spermatogenic Failure, Susceptibility To Absent Sperm Aspermatogenesis Infertility Due To Azoospermia Hypospermatogenesis Azoospermatism
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Papillary Adenofibroma
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14872	Tideglusib	Inhibitor	99.70%	Yes

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-104036	IDH-305	Inhibitor	99.15%	Phase 2
HY-P11084	WT1 126-134 peptide		98.89%	Phase 2

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122913	Borussertib	Inhibitor	99.18%	Unkown
HY-W143698	PDGFRα kinase inhibitor 2	Inhibitor	98.95%	Unkown
HY-RS17032	Wt1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-P11084A	WT1 126-134 peptide acetate		99.12%	Unkown
HY-RS15853	WT1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-120765	BRD2879	Inhibitor	/	Unkown
HY-RS23476	Wt1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99650	Grisnilimab	Inhibitor	99.43%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	WT1	VGNC	VGNC:67095
Mus musculus	WT1	MGD	MGI:98968
Canis familiaris	WT1	VGNC	VGNC:48438
Bos taurus	WT1	VGNC	VGNC:59373
Rattus norvegicus	WT1	RGD	RGD:3974
Macaca mulatta	WT1	VGNC	VGNC:78804
Others	WT1	NCBI