Yap1 - yes-associated protein 1 Gene

Also Known as Yap; Yki; Yap65; Yorkie

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22601

About Yap1

Chromosome 9: 7,932,000-8,004,597 reverse strand.GRCm39:CM001002.3

This gene has 10 transcripts (splice variants), 219 orthologues, 1 paralogue and is associated with 30 phenotypes. Ubiquitous expression in limb E14.5 (RPKM 25.3), bladder adult (RPKM 22.8) and 28 other tissues.

Summary

This gene encodes a protein which binds to the SH3 domain of the Yes proto-oncogene product, a tyrosine kinase. This protein contains a WW domain, consisting of four conserved aromatic Amino acids including two tryptophan residues. This conserved WW domain is found in various structural, regulatory and signaling molecules in various species, and may play a role in protein-protein interaction. Following cellular damage, phosphorylation of this encoded protein may suppress Apoptosis. This protein may be involved in malignant transformation in Cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]

Yap1 Products (2)

mRNA Protein Name
NM_009534.3 NP_033560.1 transcriptional coactivator YAP1 isoform 2
NM_001171147.1 NP_001164618.1 transcriptional coactivator YAP1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
20516196 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
19952108 MGI
enables proline-rich region binding IPI
IPI: Inferred from physical interaction
9305852 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11278685 MGI
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
16332960 MGI
enables transcription coactivator activity IMP
IMP: Inferred from mutant phenotype
26902285 MGI
enables transcription factor binding IPI
IPI: Inferred from physical interaction
19952108 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of blastocyst development IMP
IMP: Inferred from mutant phenotype
26902285 MGI
acts upstream of or within bud elongation involved in lung branching IMP
IMP: Inferred from mutant phenotype
25043473 MGI
acts upstream of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
17980593 MGI
involved in cardiac muscle tissue regeneration IMP
IMP: Inferred from mutant phenotype
23918388 MGI
acts upstream of or within cell morphogenesis IMP
IMP: Inferred from mutant phenotype
20516196 MGI
acts upstream of cell population proliferation IDA
IDA: Inferred from direct assay
17980593 MGI
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
19853564 MGI
acts upstream of or within cellular response to retinoic acid IDA
IDA: Inferred from direct assay
21385842 MGI
acts upstream of or within embryonic heart tube morphogenesis IGI
IGI: Inferred from genetic interaction
18332127 MGI
acts upstream of enterocyte differentiation IDA
IDA: Inferred from direct assay
17980593 MGI
acts upstream of epithelial cell proliferation IDA
IDA: Inferred from direct assay
17980593 MGI
involved in epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
29400695 MGI
acts upstream of extrinsic apoptotic signaling pathway IGI
IGI: Inferred from genetic interaction
17980593 MGI
acts upstream of glandular epithelial cell differentiation IDA
IDA: Inferred from direct assay
17980593 MGI
involved in heart process IMP
IMP: Inferred from mutant phenotype
23918388 MGI
acts upstream of or within hippo signaling IGI
IGI: Inferred from genetic interaction
18369314 MGI
involved in interleukin-6-mediated signaling pathway IDA
IDA: Inferred from direct assay
25731159 MGI
involved in intestinal epithelial cell development IDA
IDA: Inferred from direct assay
25731159 MGI
acts upstream of intestinal epithelial cell differentiation IDA
IDA: Inferred from direct assay
17980593 MGI
acts upstream of or within keratinocyte differentiation IGI
IGI: Inferred from genetic interaction
18369314 MGI
acts upstream of or within keratinocyte differentiation IMP
IMP: Inferred from mutant phenotype
18369314 MGI
acts upstream of or within lateral mesoderm development IGI
IGI: Inferred from genetic interaction
18332127 MGI
acts upstream of or within lung epithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
25043473 MGI
acts upstream of or within negative regulation of epithelial cell differentiation IDA
IDA: Inferred from direct assay
17980593 MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway IGI
IGI: Inferred from genetic interaction
17980593 MGI
acts upstream of or within negative regulation of stem cell differentiation IDA
IDA: Inferred from direct assay
20516196 MGI
acts upstream of or within notochord development IGI
IGI: Inferred from genetic interaction
18332127 MGI
acts upstream of organ growth IDA
IDA: Inferred from direct assay
17980593 MGI
involved in organ growth IMP
IMP: Inferred from mutant phenotype
29400695 MGI
acts upstream of or within paraxial mesoderm development IGI
IGI: Inferred from genetic interaction
18332127 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
26902285 MGI
involved in positive regulation of Notch signaling pathway IDA
IDA: Inferred from direct assay
25731159 MGI
acts upstream of or within positive regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
17980593 MGI
involved in positive regulation of cardiac muscle cell proliferation IDA
IDA: Inferred from direct assay
23918388 MGI
acts upstream of or within positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
17980593 MGI
acts upstream of or within positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
19853564 MGI
acts upstream of or within positive regulation of epithelial cell proliferation IDA
IDA: Inferred from direct assay
17980593 MGI
acts upstream of or within positive regulation of organ growth IDA
IDA: Inferred from direct assay
17980593 MGI
involved in positive regulation of protein localization to nucleus IMP
IMP: Inferred from mutant phenotype
21145499 MGI
acts upstream of or within positive regulation of stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
20516196 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
20516196 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11358867 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
16207754 MGI
acts upstream of or within regulation of canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
23974041 MGI
acts upstream of or within regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
19004856 MGI
acts upstream of or within regulation of gene expression IGI
IGI: Inferred from genetic interaction
27288457 MGI
acts upstream of or within regulation of keratinocyte proliferation IMP
IMP: Inferred from mutant phenotype
18369314 MGI
acts upstream of or within regulation of metanephric nephron tubule epithelial cell differentiation IGI
IGI: Inferred from genetic interaction
23974041 MGI
acts upstream of or within regulation of stem cell proliferation IDA
IDA: Inferred from direct assay
19952108 MGI
acts upstream of or within regulation of stem cell proliferation IGI
IGI: Inferred from genetic interaction
25433207 MGI
acts upstream of or within regulation of stem cell proliferation IMP
IMP: Inferred from mutant phenotype
19853564 MGI
acts upstream of or within somatic stem cell population maintenance IDA
IDA: Inferred from direct assay
17980593 MGI
involved in tissue homeostasis IMP
IMP: Inferred from mutant phenotype
23918388 MGI
acts upstream of trophectodermal cell differentiation IMP
IMP: Inferred from mutant phenotype
26902285 MGI
acts upstream of or within vasculogenesis IMP
IMP: Inferred from mutant phenotype
16354681 MGI
involved in wound healing IMP
IMP: Inferred from mutant phenotype
23918388 MGI
Cellular Component GO Annotation Evidence References Source
part of TEAD-YAP complex IPI
IPI: Inferred from physical interaction
11358867 MGI
located in cell-cell junction IDA
IDA: Inferred from direct assay
29400695 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
18369314 MGI
located in cytosol IDA
IDA: Inferred from direct assay
21385842 MGI
located in female germ cell nucleus IDA
IDA: Inferred from direct assay
26902285 MGI
located in membrane IDA
IDA: Inferred from direct assay
23863479 MGI
is active in nucleus IDA
IDA: Inferred from direct assay
26902285 MGI
located in nucleus IDA
IDA: Inferred from direct assay
18369314 MGI
part of transcription regulator complex IGI
IGI: Inferred from genetic interaction
16207754 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Yap1 Protein Structure

WW

WW: cd00201 (158 - 187)

WW

WW: smart00456 (215 - 247)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 488 a.a.
Protein Preferred Names Protein Names

transcriptional coactivator YAP1

  • 65 kDa Yes-associated protein

  • Yes-associated protein isoform a474

  • Yes-associated protein isoform a475

  • Yes-associated protein isoform a476

  • Yes-associated protein isoform b309

  • Yes-associated protein isoform b313

  • Yes-associated protein isoform b325

  • protein yorkie homolog

  • yes-associated protein YAP65 homolog

  • yes-associated protein, 65 kDa

  • yorkie homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-176542 TD034 Inhibitor 99.77% Unkown
HY-175649 LATS1/2-IN-1 Inhibitor / Unkown
HY-E70293 N-Acetylgalactosaminyltransferase 12 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Yap1 NCBI NCBI:10413