2. Gene
  3. Yap1 - yes-associated protein 1 Gene

Yap1 - yes-associated protein 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Yap; Yki; Yap65; Yorkie

Gene ID: 22601 | Gene type: protein coding

About Yap1

Chromosome 9: 7,932,000-8,004,597 reverse strand.GRCm39:CM001002.3

This gene has 10 transcripts (splice variants), 219 orthologues, 1 paralogue and is associated with 30 phenotypes. Ubiquitous expression in limb E14.5 (RPKM 25.3), bladder adult (RPKM 22.8) and 28 other tissues.

Summary

This gene encodes a protein which binds to the SH3 domain of the Yes proto-oncogene product, a tyrosine kinase. This protein contains a WW domain, consisting of four conserved aromatic Amino acids including two tryptophan residues. This conserved WW domain is found in various structural, regulatory and signaling molecules in various species, and may play a role in protein-protein interaction. Following cellular damage, phosphorylation of this encoded protein may suppress Apoptosis. This protein may be involved in malignant transformation in Cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]

Yap1 Products(2)

mRNA Protein Name
NM_009534.3 NP_033560.1 transcriptional coactivator YAP1 isoform 2
NM_001171147.1 NP_001164618.1 transcriptional coactivator YAP1 isoform 1

Yap1 Protein Structure

WW

WW: cd00201 (158 - 187)

WW

WW: smart00456 (215 - 247)

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  • 488 a.a.
Protein Preferred Names Protein Names

transcriptional coactivator YAP1

65 kDa Yes-associated protein

Yes-associated protein isoform a474

Yes-associated protein isoform a475

Yes-associated protein isoform a476

Yes-associated protein isoform b309

Yes-associated protein isoform b313

Yes-associated protein isoform b325

protein yorkie homolog

yes-associated protein YAP65 homolog

yes-associated protein, 65 kDa

yorkie homolog

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N6682 Cytochalasin D Inhibitor 99.79% Unkown
HY-138565 K-975 Inhibitor 99.27% Unkown
HY-125269 TED-347 Inhibitor 98.97% Unkown
HY-156024 TEAD-IN-6 Modulator / Unkown
HY-RS15911 YAP1 Human Pre-designed siRNA Set A / Unkown
HY-RS15912 Yap1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS15913 Yap1 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Yap1 NCBI NCBI:10413