FBXO21 - F-box protein 21 Gene

Also Known as FBX21

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23014

About FBXO21

Cytogenetic location: 12q24.22 Genomic coordinates (GRCh38): 12:117,141,991-117,190,470 (from NCBI)

This gene has 7 transcripts (splice variants) and 201 orthologues. Ubiquitous expression in testis (RPKM 31.4), ovary (RPKM 26.9) and 25 other tissues.

Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein Ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]

FBXO21 Products (2)

mRNA Protein Name
NM_015002.3 NP_055817.1 F-box only protein 21 isoform 2
NM_033624.3 NP_296373.1 F-box only protein 21 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
26085330 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FBXO21 Protein Structure

F-box-like

F-box-like: F-box-like (32 - 76)

Transglut_core2

Transglut_core2: Transglutaminase-like superfamily (216 - 389)

YccV-like

YccV-like: Hemimethylated DNA-binding protein YccV like (501 - 597)

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  • 500
  • 628 a.a.
Protein Preferred Names Protein Names

F-box only protein 21

FBXO21 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FBXO21 O94952 EID1 Homo sapiens Q9Y6B2
Anti Tag CoIP
26085330
Intra
FBXO21 O94952 EID1 Homo sapiens Q9Y6B2
Confocal
26085330
Intra
FBXO21 O94952 SKP1 Homo sapiens P63208
Anti Tag CoIP
26085330
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04798 FBXO21 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus FBXO21 VGNC VGNC:28898
Rattus norvegicus FBXO21 RGD RGD:1307346
Canis familiaris FBXO21 VGNC VGNC:40766
Mus musculus FBXO21 MGD MGI:1924223
Macaca mulatta FBXO21 VGNC VGNC:72494
Felis catus FBXO21 VGNC VGNC:62180
Others FBXO21 NCBI