USP33 - ubiquitin specific peptidase 33 Gene

Also Known as VDU1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23032

About USP33

Cytogenetic location: 1p31.1 Genomic coordinates (GRCh38): 1:77,695,987-77,759,852 (from NCBI)

This gene has 18 transcripts (splice variants), 211 orthologues and 71 paralogues. Ubiquitous expression in fat (RPKM 19.0), brain (RPKM 15.9) and 25 other tissues.

Summary

This gene encodes a deubiquinating enzyme important in a variety of processes, including Slit-dependent cell migration and beta-2 Adrenergic Receptor signaling. The protein is negatively regulated through ubiquitination by von Hippel-Lindau tumor protein (VHL). Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]

USP33 Products (13)

mRNA Protein Name
NM_001377430.1 NP_001364359.1 ubiquitin carboxyl-terminal hydrolase 33 isoform 4
NM_001377431.1 NP_001364360.1 ubiquitin carboxyl-terminal hydrolase 33 isoform 5
NM_001377432.1 NP_001364361.1 ubiquitin carboxyl-terminal hydrolase 33 isoform 6
NM_001377433.1 NP_001364362.1 ubiquitin carboxyl-terminal hydrolase 33 isoform 7
NM_001377434.1 NP_001364363.1 ubiquitin carboxyl-terminal hydrolase 33 isoform 8
NM_001377435.1 NP_001364364.1 ubiquitin carboxyl-terminal hydrolase 33 isoform 9
NM_001377436.1 NP_001364365.1 ubiquitin carboxyl-terminal hydrolase 33 isoform 10
NM_001377437.1 NP_001364366.1 ubiquitin carboxyl-terminal hydrolase 33 isoform 11
NM_001377438.1 NP_001364367.1 ubiquitin carboxyl-terminal hydrolase 33 isoform 12
NM_001377439.1 NP_001364368.1 ubiquitin carboxyl-terminal hydrolase 33 isoform 12
NM_015017.5 NP_055832.3 ubiquitin carboxyl-terminal hydrolase 33 isoform 1
NM_201624.3 NP_963918.1 ubiquitin carboxyl-terminal hydrolase 33 isoform 2
NM_201626.3 NP_963920.1 ubiquitin carboxyl-terminal hydrolase 33 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled receptor binding IPI
IPI: Inferred from physical interaction
19424180 GOA
enables cysteine-type deubiquitinase activity IDA
IDA: Inferred from direct assay
23486064 GOA
enables cysteine-type deubiquitinase activity IMP
IMP: Inferred from mutant phenotype
24056301 GOA
enables cysteine-type endopeptidase activity IMP
IMP: Inferred from mutant phenotype
19363159 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11739384 GOA
enables small GTPase binding IPI
IPI: Inferred from physical interaction
24056301 GOA
NOT enables ubiquitin binding IDA
IDA: Inferred from direct assay
17766394 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
17766394 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to starvation IDA
IDA: Inferred from direct assay
24056301 GOA
involved in centrosome duplication IMP
IMP: Inferred from mutant phenotype
23486064 GOA
involved in negative regulation of protein binding IMP
IMP: Inferred from mutant phenotype
24056301 GOA
involved in positive regulation of protein binding IMP
IMP: Inferred from mutant phenotype
24056301 GOA
involved in protein K48-linked deubiquitination IDA
IDA: Inferred from direct assay
19363159 GOA
involved in protein K63-linked deubiquitination IDA
IDA: Inferred from direct assay
19363159 GOA
involved in protein deubiquitination IDA
IDA: Inferred from direct assay
11739384 GOA
involved in protein deubiquitination IMP
IMP: Inferred from mutant phenotype
24056301 GOA
involved in protein stabilization IMP
IMP: Inferred from mutant phenotype
23486064 GOA
involved in regulation of G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
19363159 GOA
involved in regulation of autophagy IMP
IMP: Inferred from mutant phenotype
24056301 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
21801292 GOA
located in centrosome IDA
IDA: Inferred from direct assay
23486064 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
24056301 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP33 Protein Structure

zf-UBP

zf-UBP: Zn-finger in ubiquitin-hydrolases and other protein (61 - 122)

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (184 - 712)

DUSP

DUSP: DUSP domain (847 - 916)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 942 a.a.
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase 33

  • VHL-interacting deubiquitinating enzyme 1

USP33 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
USP33 Q8TEY7 EGFR Homo sapiens P00533
Ub Reconstruction
27956147
Intra
USP33 Q8TEY7 EGFR Homo sapiens P00533
Anti Tag CoIP
27956147
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15544 USP33 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19751 Usp33 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26248 Usp33 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus USP33 VGNC VGNC:66879
Rattus norvegicus USP33 RGD RGD:1307848
Bos taurus USP33 VGNC VGNC:36723
Canis familiaris USP33 VGNC VGNC:48189
Macaca mulatta USP33 VGNC VGNC:79217
Mus musculus USP33 MGD MGI:2159711
Others USP33 NCBI