Kdm4a - lysine (K)-specific demethylase 4A Gene

Also Known as Jmjd2; JHDM3A; Jmjd2a; mKIAA0677; D4Ertd222e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 230674

Summary

Enables Histone Demethylase activity. Acts upstream of or within cardiac muscle hypertrophy in response to stress and negative regulation of histone H3-K9 trimethylation. Located in pericentric heterochromatin. Is expressed in several structures, including branchial arch; central nervous system; dorsal root ganglion; early conceptus; and genitourinary system. Orthologous to human KDM4A (lysine demethylase 4A). [provided by Alliance of Genome Resources, Apr 2022]

Kdm4a Products (2)

mRNA Protein Name
NM_001161823.1 NP_001155295.1 lysine-specific demethylase 4A isoform 1
NM_172382.2 NP_759014.2 lysine-specific demethylase 4A isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables histone H3K9 demethylase activity IDA
IDA: Inferred from direct assay
16738407 MGI
enables histone demethylase activity IDA
IDA: Inferred from direct assay
19144645 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cardiac muscle hypertrophy in response to stress IMP
IMP: Inferred from mutant phenotype
21555854 MGI
Cellular Component GO Annotation Evidence References Source
located in pericentric heterochromatin IDA
IDA: Inferred from direct assay
16738407 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lysine-specific demethylase 4A

  • [histone H3]-trimethyl-L-lysine(36) demethylase 4A

  • [histone H3]-trimethyl-L-lysine(9) demethylase 4A

  • jmjC domain-containing histone demethylation protein 3A

  • jumonji domain containing 2A

  • jumonji domain-containing protein 2A

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (16)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-104048 QC6352 Inhibitor 99.13% Unkown
HY-100760 Toxoflavin Inhibitor 99.88% Unkown
HY-148807 Zavondemstat 99.29% Unkown
HY-107573 KDM2/7-IN-1 Inhibitor 99.9% Unkown
HY-110154 NSC636819 98.90% Unkown
HY-RS07213 KDM4A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-128343 KDM4-IN-2 Inhibitor 98.29% Unkown
HY-120766 NCDM-32B Inhibitor 97.0% Unkown
HY-148807A Zavondemstat L-lysine / Unkown
HY-173135 PROTAC KDM4 degrader-1 / Unkown
HY-100760S Toxoflavin-13C4 Inhibitor / Unkown
HY-148807C Zavondemstat sodium / Unkown
HY-150619 KDM4-IN-4 Inhibitor / Unkown
HY-183618 DW-229 Degrader / Unkown
HY-RS17467 Kdm4a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23925 Kdm4a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kdm4a NCBI NCBI:9682