RGL1 - ral guanine nucleotide dissociation stimulator like 1 Gene

Also Known as RGL

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23179

About RGL1

Cytogenetic location: 1q25.3 Genomic coordinates (GRCh38): 1:183,636,109-183,928,532 (from NCBI)

This gene has 2 transcripts (splice variants), 206 orthologues and 24 paralogues. Ubiquitous expression in spleen (RPKM 23.7), brain (RPKM 15.5) and 22 other tissues.

Summary

Predicted to be involved in regulation of catalytic activity. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

RGL1 Products (5)

mRNA Protein Name
NM_001297669.3 NP_001284598.1 ral guanine nucleotide dissociation stimulator-like 1 isoform 2
NM_001297670.3 NP_001284599.1 ral guanine nucleotide dissociation stimulator-like 1 isoform 2
NM_001297671.3 NP_001284600.1 ral guanine nucleotide dissociation stimulator-like 1 isoform 3
NM_001297672.3 NP_001284601.1 ral guanine nucleotide dissociation stimulator-like 1 isoform 4
NM_015149.6 NP_055964.3 ral guanine nucleotide dissociation stimulator-like 1 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20936779 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RGL1 Protein Structure

RasGEF_N

RasGEF_N: RasGEF N-terminal motif (69 - 173)

RasGEF

RasGEF: RasGEF domain (230 - 450)

RA

RA: Ras association (RalGDS/AF-6) domain (648 - 734)

  • 0
  • 200
  • 400
  • 600
  • 768 a.a.
Protein Preferred Names Protein Names

ral guanine nucleotide dissociation stimulator-like 1

  • ralGDS-like 1

RGL1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RGL1 Q9NZL6 HRAS Homo sapiens P01112
Y2H Pooling
20936779
Intra
RGL1 Q9NZL6 HRAS Homo sapiens P01112
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Nutritional Optic Neuropathy
Abnormality Of Glucagon Secretion

  • Glucagon Secretion Abnormality

  • Abnormality Of Secretion Of Glucagon
Toxic Optic Neuropathy
Neutropenia, Severe Congenital, X-Linked

  • X-Linked Severe Congenital Neutropenia

  • XLN

  • SCNX

  • Severe Congenital Neutropenia X-Linked

  • Neutropenia, Congenital, Severe, X-Linked
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11890 RGL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00942 ARHGAP9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RGL1 MGD MGI:107484
Rattus norvegicus RGL1 RGD RGD:1308947
Felis catus RGL1 VGNC VGNC:64590
Bos taurus RGL1 VGNC VGNC:33903
Macaca mulatta RGL1 VGNC VGNC:76868
Canis familiaris RGL1 VGNC VGNC:45512
Others RGL1 NCBI