Aimp2 - aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 Gene

Also Known as Jtv1; Aimp2(p38)

Species: Mus musculus

Gene Type: protein coding
Gene ID: 231872

Summary

Enables molecular adaptor activity. Involved in positive regulation of aminoacyl-tRNA Ligase activity and protein-containing complex assembly. Acts upstream of or within negative regulation of cell population proliferation; positive regulation of protein ubiquitination; and type II pneumocyte differentiation. Located in nucleus. Part of Aminoacyl-tRNA Synthetase multienzyme complex. Is expressed in several structures, including olfactory epithelium; orbito-sphenoid; submandibular gland primordium; thymus primordium; and tooth. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy. Orthologous to human AIMP2 (aminoacyl tRNA synthetase complex interacting multifunctional protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Aimp2 Products (2)

mRNA Protein Name
NM_001172146.1 NP_001165617.1 aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform 1
NM_146165.2 NP_666277.1 aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables molecular adaptor activity IMP
IMP: Inferred from mutant phenotype
12060739 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12060739 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
12819782 MGI
acts upstream of or within positive regulation of protein ubiquitination IDA
IDA: Inferred from direct assay
12819782 MGI
acts upstream of protein ubiquitination IDA
IDA: Inferred from direct assay
12819782 MGI
involved in protein-containing complex assembly IMP
IMP: Inferred from mutant phenotype
12060739 MGI
acts upstream of or within type II pneumocyte differentiation IMP
IMP: Inferred from mutant phenotype
12819782 MGI
Cellular Component GO Annotation Evidence References Source
part of aminoacyl-tRNA synthetase multienzyme complex IMP
IMP: Inferred from mutant phenotype
12060739 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12819782 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

aminoacyl tRNA synthase complex-interacting multifunctional protein 2

  • ARS interacting multifunctional protein 2

  • multisynthase complex auxiliary component p38

  • multisynthetase complex auxiliary component p38

  • protein JTV-1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-136431 BC-DXI-843 Inhibitor 99.76% Unkown
HY-150719 AIMP2-DX2-IN-1 ≥98.0% Unkown
HY-182399 BC-DXI-495 Inhibitor / Unkown
HY-RS00498 AIMP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20364 Aimp2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26873 Aimp2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aimp2 NCBI NCBI:7965