FBXO46 - F-box protein 46 Gene

Also Known as Fbx46; FBXO34L; 20D7-FC4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23403

Summary

Members of the F-box protein family, such as FBXO46, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Ubiquitous expression in spleen (RPKM 4.8), testis (RPKM 4.4) and 25 other tissues.

FBXO46 Products (4)

mRNA Protein Name
NM_001080469.2 NP_001073938.1 F-box only protein 46
NM_001329632.1 NP_001316561.1 F-box only protein 46
NM_001329633.2 NP_001316562.1 F-box only protein 46
NM_001329634.1 NP_001316563.1 F-box only protein 46

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19159283 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FBXO46 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FBXO46 Q6PJ61 SKP1 Homo sapiens P63208
Anti Tag CoIP
19159283
Intra
FBXO46 Q6PJ61 SKP1 Homo sapiens P63208
Anti Tag CoIP
22632967
Intra
FBXO46 Q6PJ61 SKP1 Homo sapiens P63208
MAPPIT
19159283
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04806 FBXO4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04807 FBXO40 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04808 FBXO42 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04809 FBXO44 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04810 FBXO47 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04812 FBXO6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18517 Fbxo4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21127 Fbxo44 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21571 Fbxo6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24999 Fbxo4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27645 Fbxo44 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28089 Fbxo6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown