MORC3 - MORC family CW-type zinc finger 3 Gene

Also Known as NXP2; ZCW5; ZCWCC3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23515

About MORC3

Cytogenetic location: 21q22.12 Genomic coordinates (GRCh38): 21:36,320,197-36,376,632 (from NCBI)

This gene has 12 transcripts (splice variants), 238 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 15.2), ovary (RPKM 12.6) and 25 other tissues.

Summary

This gene encodes a protein that localizes to the nuclear matrix and forms nuclear bodies via an ATP-dependent mechanism. The protein is predicted to have coiled-coil and zinc finger domains and has RNA binding activity. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2016]

MORC3 Products (3)

mRNA	Protein	Name
NM_001320445.2	NP_001307374.1	MORC family CW-type zinc finger protein 3 isoform 2
NM_001320446.2	NP_001307375.1	MORC family CW-type zinc finger protein 3 isoform 2
NM_015358.3	NP_056173.1	MORC family CW-type zinc finger protein 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	34759314	GOA
enables methylated histone binding	IDA IDA: Inferred from direct assay	26933034	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	26496610	GOA
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	27440897	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in antiviral innate immune response	IDA IDA: Inferred from direct assay	27440897	GOA
acts upstream of or within maintenance of protein location in nucleus	IDA IDA: Inferred from direct assay	17332504	GOA
acts upstream of or within maintenance of protein location in nucleus	IMP IMP: Inferred from mutant phenotype	17332504	GOA
acts upstream of or within negative regulation of fibroblast proliferation	IDA IDA: Inferred from direct assay	17332504	GOA
involved in negative regulation of interferon-beta production	IDA IDA: Inferred from direct assay	34759314	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	34759314	GOA
acts upstream of or within peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	17332504	GOA
acts upstream of or within positive regulation of cellular senescence	IDA IDA: Inferred from direct assay	17332504	GOA
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	17332504	GOA
acts upstream of or within protein stabilization	IDA IDA: Inferred from direct assay	17332504	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in PML body	IDA IDA: Inferred from direct assay	27440897	GOA
located in PML body	IDA IDA: Inferred from direct assay	17332504	GOA
located in chromatin	IDA IDA: Inferred from direct assay	34759314	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MORC3 Protein Structure

HATPase_c_3

zf-CW

0
200
400
600
800
939 a.a.

Protein Preferred Names	Protein Names
MORC family CW-type zinc finger protein 3	nuclear matrix protein 2

MORC3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MORC3	Q14149	DYNLL1	Homo sapiens	P63167	Anti Tag CoIP	26496610
Intra	MORC3	Q14149	DYNLL1	Homo sapiens	P63167	Y2H Fragment Pooling	35914814
Intra	MORC3	Q14149	RNF216	Homo sapiens	Q9NWF9	Validated Y2H	32296183
Intra	MORC3	Q14149	RNF216	Homo sapiens	Q9NWF9	Y2H Array	32296183
Intra	MORC3	Q14149	RNF216	Homo sapiens	Q9NWF9	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MORC3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71545	MORC3 Protein, Human (His-SUMO)	Q14149 (M1-Y290)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Adult Dermatomyositis	Adult Onset Dermatomyositis Adult Type Dermatomyositis
Antisynthetase Syndrome	As Syndrome Anti-Jo1 Syndrome
Orbital Plasma Cell Granuloma	Orbital Myositis Orbital Pseudotumor Pseudotumor Of Orbit Plasma Cell Granuloma, Orbital
Influenza	Flu Influenza With Non-Respiratory Manifestation Influenza With Other Manifestations Influenza, Human Influenza, Susceptibility To Seasonal Influenza, Virus Identified
Renal Pelvis Squamous Cell Carcinoma	Epidermoid Carcinoma Of The Kidney Pelvis Squamous Cell Carcinoma Of Renal Pelvis
Childhood Type Dermatomyositis	Juvenile Dermatomyositis Juvenile Dm Childhood Dermatomyositis Amyopathic Dermatomyositis Adm Dermatomyositis Sine Myositis Dermatomyositis, Childhood Type
Chronic Orbital Inflammation	Chronic Inflammation Of Orbit
Nodular Prostate
Muscle Tissue Disease
Exanthem	Exanthema Rash Rashes
Muscular Disease
Myopathy	Muscular Diseases Myopathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08591	MORC3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21653	Morc3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28171	Morc3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MORC3	VGNC	VGNC:74809
Rattus norvegicus	MORC3	RGD	RGD:1307924
Bos taurus	MORC3	VGNC	VGNC:31556
Mus musculus	MORC3	MGD	MGI:2136841
Canis familiaris	MORC3	VGNC	VGNC:43318
Felis catus	MORC3	VGNC	VGNC:63558
Others	MORC3	NCBI