Dlat - dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) Gene

Also Known as DLTA; PDC-E2; 6332404G05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 235339

Summary

Predicted to enable dihydrolipoyllysine-residue acetyltransferase activity and identical protein binding activity. Predicted to contribute to pyruvate dehydrogenase (NAD+) activity. Predicted to be involved in acetyl-CoA biosynthetic process from pyruvate. Predicted to act upstream of or within mitochondrial acetyl-CoA biosynthetic process from pyruvate. Located in mitochondrion and myelin sheath. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and respiratory system. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human DLAT (dihydrolipoamide S-acetyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Dlat Products (1)

mRNA Protein Name
NM_145614.4 NP_663589.3 dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables acetyltransferase activity IMP
IMP: Inferred from mutant phenotype
27621431 MGI
Biological Process GO Annotation Evidence References Source
involved in acetyl-CoA biosynthetic process from pyruvate IMP
IMP: Inferred from mutant phenotype
17314311 MGI
Cellular Component GO Annotation Evidence References Source
is active in mitochondrial matrix IDA
IDA: Inferred from direct assay
9405644 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

  • PDCE2

  • dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex

  • pyruvate dehydrogenase complex component E2

Recombinant Dlat Proteins

Cat. No. Product Name Accession Purity
HY-P71676 PDCE2 Protein, Mouse (HEK293, His) Q8BMF4 (S86-L642) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-162386 UM4118 99.95% Unkown
HY-RS03792 DLAT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-178914 Copper ionophore I 99.9% Unkown
HY-RS17105 Dlat Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-116330 Hyperforin / Unkown
HY-P12010 Ac-ETDK(myr)-AMC / Unkown
HY-RS23549 Dlat Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dlat NCBI NCBI:1737