Setd2 - SET domain containing 2 Gene

Also Known as KMT3A; 4921524K10Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 235626

Summary

Enables Histone Methyltransferase activity (H3-K36 specific). Involved in endodermal cell differentiation; histone H3-K36 trimethylation; and stem cell differentiation. Acts upstream of or within several processes, including animal organ development; peptidyl-lysine methylation; and tube morphogenesis. Located in chromosome and nucleus. Is expressed in 1-cell stage embryo; 2-cell stage embryo; 4-cell stage embryo; 8-cell stage embryo; and inner cell mass. Human ortholog(s) of this gene implicated in carcinoma (multiple); gastrointestinal system Cancer (multiple); idiopathic pulmonary fibrosis; and malignant mesothelioma. Orthologous to human SETD2 (SET domain containing 2, histone lysine methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Setd2 Products (1)

mRNA Protein Name
NM_001081340.3 NP_001074809.2 histone-lysine N-methyltransferase SETD2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables histone H3K36 methyltransferase activity IMP
IMP: Inferred from mutant phenotype
18157086 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within angiogenesis IMP
IMP: Inferred from mutant phenotype
20133625 MGI
acts upstream of or within cell migration involved in vasculogenesis IMP
IMP: Inferred from mutant phenotype
20133625 MGI
acts upstream of or within coronary vasculature morphogenesis IMP
IMP: Inferred from mutant phenotype
20133625 MGI
acts upstream of or within embryonic cranial skeleton morphogenesis IMP
IMP: Inferred from mutant phenotype
20133625 MGI
acts upstream of or within embryonic organ development IMP
IMP: Inferred from mutant phenotype
20133625 MGI
acts upstream of or within embryonic placenta morphogenesis IMP
IMP: Inferred from mutant phenotype
20133625 MGI
involved in endodermal cell differentiation IMP
IMP: Inferred from mutant phenotype
25242323 MGI
acts upstream of or within forebrain development IMP
IMP: Inferred from mutant phenotype
20133625 MGI
acts upstream of or within mesoderm morphogenesis IMP
IMP: Inferred from mutant phenotype
20133625 MGI
acts upstream of or within morphogenesis of a branching structure IMP
IMP: Inferred from mutant phenotype
20133625 MGI
acts upstream of or within neural tube closure IMP
IMP: Inferred from mutant phenotype
20133625 MGI
acts upstream of or within peptidyl-lysine trimethylation IMP
IMP: Inferred from mutant phenotype
18157086 MGI
acts upstream of or within pericardium development IMP
IMP: Inferred from mutant phenotype
20133625 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
20133625 MGI
acts upstream of or within stem cell development IMP
IMP: Inferred from mutant phenotype
20133625 MGI
involved in stem cell differentiation IMP
IMP: Inferred from mutant phenotype
25242323 MGI
acts upstream of or within vasculogenesis IMP
IMP: Inferred from mutant phenotype
20133625 MGI
Cellular Component GO Annotation Evidence References Source
located in chromosome IDA
IDA: Inferred from direct assay
18157086 MGI
located in nucleus IDA
IDA: Inferred from direct assay
11092755 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

histone-lysine N-methyltransferase SETD2

  • SET domain-containing protein 2

  • lysine N-methyltransferase 3A

  • protein-lysine N-methyltransferase SETD2

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-136328 EZM0414 TFA Inhibitor 97.20% Phase 1
HY-144858 EZM0414 Inhibitor 99.11% Phase 1

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-139626 EPZ-719 Inhibitor 99.00% Unkown
HY-173156 UNC10013 Modulator 99.90% Unkown
HY-P10463A ssK36 TFA Inhibitor 99.34% Unkown
HY-RS12742 SETD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-124699 MMSET-IN-1 Inhibitor / Unkown
HY-P10463 ssK36 Inhibitor / Unkown
HY-RS16976 Setd2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23419 Setd2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Setd2 NCBI NCBI:29072