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PADI4 - peptidyl arginine deiminase 4 Gene

Also Known as PAD; PAD4; PDI4; PDI5; PADI5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23569

About PADI4

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:17,308,197-17,364,004 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 235 orthologues and 4 paralogues. Restricted expression toward bone marrow (RPKM 64.4).

Summary

This gene is a member of a gene family which encodes Enzymes responsible for the conversion of arginine residues to citrulline residues. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response. [provided by RefSeq, Jul 2008]

PADI4 Products (1)

mRNA	Protein	Name
NM_012387.3	NP_036519.2	protein-arginine deiminase type-4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	16567635	GOA
enables histone H3R17 arginine deiminase activity	IDA IDA: Inferred from direct assay	15339660	GOA
enables histone H3R2 arginine deiminase activity	IDA IDA: Inferred from direct assay	15339660	GOA
enables histone H3R26 arginine deiminase activity	IDA IDA: Inferred from direct assay	15339660	GOA
enables histone H3R8 arginine deiminase activity	IDA IDA: Inferred from direct assay	15339660	GOA
enables histone arginine deiminase activity	IDA IDA: Inferred from direct assay	16567635	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	15247907	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein-arginine deiminase activity	IDA IDA: Inferred from direct assay	21584310	GOA
enables protein-arginine deiminase activity	IMP IMP: Inferred from mutant phenotype	15247907	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in post-translational protein modification	IDA IDA: Inferred from direct assay	15339660	GOA
involved in post-translational protein modification	IMP IMP: Inferred from mutant phenotype	15247907	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	15339660	GOA
part of protein-containing complex	IMP IMP: Inferred from mutant phenotype	15247907	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PADI4 Protein Structure

PAD_N

PAD_M

PAD

0
200
400
600
663 a.a.

Protein Preferred Names	Protein Names
protein-arginine deiminase type-4	HL-60 PAD

PADI4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PADI4	Q9UM07	POU6F2	Homo sapiens	P78424	Y2H Prey Pooling	32296183
Intra	PADI4	Q9UM07	POU6F2	Homo sapiens	P78424	Y2H Array	32296183
Intra	PADI4	Q9UM07	ANXA4	Homo sapiens	P09525	Y2H Array	25416956
Intra	PADI4	Q9UM07	ANXA4	Homo sapiens	P09525	Validated Y2H	25416956
Intra	PADI4	Q9UM07	ANXA4	Homo sapiens	P09525	Y2H Prey Pooling	25416956
Intra	PADI4	Q9UM07	TRIB3	Homo sapiens	Q96RU7	Y2H Prey Pooling	32296183
Intra	PADI4	Q9UM07	TRIB3	Homo sapiens	Q96RU7	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PADI4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70990	PADI4 Protein, Human (His)	AAH25718.1 (M1-P663)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P701030	PADI4 Protein, Human (Biotinylated, His)	Q9UM07/AAH25718.1 (M1-P663)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Arthritis	Inflammatory Joint Disease Inflammatory Disorder Of Joint
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease
Felty Syndrome	Felty'S Syndrome Rheumatoid Arthritis With Splenoadenomegaly And Leukopenia Familial Felty'S Syndrome Rheumatoid Arthritis, Splenomegaly And Neutropenia Splenomegaly-Neutropenia-Rheumatoid Arthritis Syndrome Feltys Syndrome
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Caplan'S Syndrome	Caplan Syndrome Caplan'S Disease Caplans Syndrome Rheumatoid Pneumoconiosis
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Cervical Polyp	Cervix Adenomatous Polyp
Papillon-Lefevre Syndrome	Papillon-Lefevre Disease Papillon-Lefèvre Syndrome PLS Keratosis Palmoplantaris With Periodontopathia PALS Papillon Lefevre Syndrome Keratosis Palmoplantar-Periodontopathy Syndrome Papillon-Lefvre Syndrome Hyperkeratosis Palmoplantaris With Periodontosis Keratoris Palmoplantaris With Periodontopathia Keratosis Palmoplantar - Periodontopathy Palmar-Plantar Hyperkeratosis And Concomitant Periodontal Destruction Palmoplantar Keratoderma With Periodontosis Palsy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-175518	PADI4-IN-1	Inhibitor	/	Unkown
HY-P11868	PADI4_3	Inhibitor	/	Unkown
HY-P11869	PADI4_11	Activator	/	Unkown
HY-P11870	PADI4_7	Ligand	/	Unkown
HY-RS09963	PADI4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18293	Padi4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24771	Padi4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PADI4	VGNC	VGNC:80298
Canis familiaris	PADI4	VGNC	VGNC:44237
Macaca mulatta	PADI4	VGNC	VGNC:100024
Rattus norvegicus	PADI4	RGD	RGD:3290
Bos taurus	PADI4	VGNC	VGNC:32548
Mus musculus	PADI4	MGD	MGI:1338898
Macaca fascicularis	PADI4	NCBI	NCBI:102126460
Others	PADI4	NCBI