Nox1 - NADPH oxidase 1 Gene

Also Known as MOX1; NOH1; NOH-1; NOX1a; Nox-1; GP91-2; NOX1alpha

Species: Mus musculus

Gene Type: protein coding

Gene ID: 237038

About Nox1

Chromosome X: 132,987,170-133,122,705 reverse strand.GRCm39:CM001013.3

This gene has 5 transcripts (splice variants), 126 orthologues, 5 paralogues and is associated with 10 phenotypes. Broad expression in frontal lobe adult (RPKM 2.), cortex adult (RPKM 1.8) and 16 other tissues.

Summary

This gene encodes a subunit of the NADPH Oxidase enzyme, which is a membrane-bound, multisubunit protein. This complex catalyzes the transfer of electrons from NADPH to molecular oxygen to produce superoxide or hydrogen peroxide and may have a role in antimicrobial killing and cell signaling. This protein binds Other subunits in order to produce superoxide. In mouse, deficiency of this enzyme may be associated with changes in blood pressure. [provided by RefSeq, Jun 2013]

Nox1 Products (1)

mRNA	Protein	Name
NM_172203.2	NP_757340.1	NADPH oxidase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables superoxide-generating NAD(P)H oxidase activity	IDA IDA: Inferred from direct assay	12473664	MGI
enables superoxide-generating NAD(P)H oxidase activity	IMP IMP: Inferred from mutant phenotype	18397177	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of JNK cascade	IMP IMP: Inferred from mutant phenotype	19661248	MGI
acts upstream of MAPK cascade	IMP IMP: Inferred from mutant phenotype	19661248	MGI
acts upstream of or within cellular response to hyperoxia	IMP IMP: Inferred from mutant phenotype	19661248	MGI
acts upstream of or within extracellular matrix organization	IMP IMP: Inferred from mutant phenotype	16386251	MGI
acts upstream of intrinsic apoptotic signaling pathway in response to oxidative stress	IMP IMP: Inferred from mutant phenotype	19661248	MGI
acts upstream of or within oxygen metabolic process	IMP IMP: Inferred from mutant phenotype	16386251	MGI
acts upstream of or within positive regulation of JNK cascade	IMP IMP: Inferred from mutant phenotype	19661248	MGI
acts upstream of or within positive regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	19661248	MGI
acts upstream of or within positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	19661248	MGI
acts upstream of or within regulation of systemic arterial blood pressure by renin-angiotensin	IMP IMP: Inferred from mutant phenotype	16386251	MGI
acts upstream of or within superoxide anion generation	IMP IMP: Inferred from mutant phenotype	18397177	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19471020	MGI
located in endosome	IMP IMP: Inferred from mutant phenotype	18397177	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Nox1 Protein Structure

Ferric_reduct

NOX_Duox_like_FAD_NADP

0
100
200
300
400
500
563 a.a.

Protein Preferred Names	Protein Names
NADPH oxidase 1	GP91 phox homolog NADH/NADPH mitogenic oxidase subunit p65-mox NADPH oxidase 1 alpha

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0807A	Prochlorperazine dimaleate	Inhibitor	≥98.0%	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12298	Setanaxib	Inhibitor	99.81%	Phase 2
HY-120801A	APX-115 free base	Inhibitor	99.54%	Phase 2

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12805	ML171	Inhibitor	99.53%	Unkown
HY-120801	APX-115	Inhibitor	99.90%	Unkown
HY-101499	GKT136901	Inhibitor	99.33%	Unkown
HY-P1435	NoxA1ds	Inhibitor	95.34%	Unkown
HY-126195	Fluoflavine	Inhibitor	98.47%	Unkown
HY-105946	Hidrosmin	Inhibitor	95.34%	Unkown
HY-P1435A	NoxA1ds TFA	Inhibitor	/	Unkown
HY-174818	NOX5-IN-2	Inhibitor	/	Unkown
HY-174817	NOX5-IN-1	Inhibitor	/	Unkown
HY-148936	GLX481372	Inhibitor	/	Unkown
HY-183101	AMPAR modulator-12	Inhibitor	/	Unkown
HY-124487	GK-136901	Inhibitor	/	Unkown
HY-128004	ML171 analog 1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nox1	NCBI	NCBI:27035