Agt - angiotensinogen Gene

Also Known as Ang; PAT; ANRT; AngII

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24179

Summary

Enables hormone activity. Involved in several processes, including MAPK cascade; regulation of ion transport; and regulation of secretion. Located in cytoplasm and extracellular space. Used to study several diseases, including artery disease (multiple); diabetic retinopathy; gastric ulcer; impotence; and sciatic neuropathy. Biomarker of several diseases, including cerebrovascular disease (multiple); glomerulonephritis (multiple); liver cirrhosis (multiple); lung disease (multiple); and prediabetes syndrome. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Henoch-Schoenlein purpura; artery disease (multiple); heart conduction disease (multiple); and hydronephrosis. Orthologous to human AGT (Angiotensinogen). [provided by Alliance of Genome Resources, Apr 2022]

Agt Products (1)

mRNA Protein Name
NM_134432.2 NP_602308.1 angiotensinogen precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables hormone activity IDA
IDA: Inferred from direct assay
8348686 RGD
Biological Process GO Annotation Evidence References Source
involved in ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
21367774 RGD
involved in G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
16286564 RGD
involved in angiotensin-mediated drinking behavior IDA
IDA: Inferred from direct assay
21281609 RGD
involved in angiotensin-mediated drinking behavior IMP
IMP: Inferred from mutant phenotype
9622148 RGD
involved in artery smooth muscle contraction IDA
IDA: Inferred from direct assay
21076237 RGD
involved in associative learning IDA
IDA: Inferred from direct assay
15245880 RGD
involved in cell growth involved in cardiac muscle cell development IDA
IDA: Inferred from direct assay
21376054 RGD
involved in cell surface receptor signaling pathway IDA
IDA: Inferred from direct assay
12130563 RGD
involved in cellular response to angiotensin IEP
IEP: Inferred from expression pattern
24431199 RGD
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
21131638 RGD
involved in female pregnancy IEP
IEP: Inferred from expression pattern
17977916 RGD
involved in fibroblast proliferation IDA
IDA: Inferred from direct assay
21419085 RGD
involved in intracellular sodium ion homeostasis IMP
IMP: Inferred from mutant phenotype
16380540 RGD
involved in negative regulation of angiogenesis IDA
IDA: Inferred from direct assay
21281454 RGD
involved in negative regulation of cell growth IMP
IMP: Inferred from mutant phenotype
15951342 RGD
involved in negative regulation of tissue remodeling IDA
IDA: Inferred from direct assay
21167013 RGD
involved in operant conditioning IDA
IDA: Inferred from direct assay
15245880 RGD
involved in positive regulation of L-arginine import across plasma membrane IDA
IDA: Inferred from direct assay
7499219 RGD
involved in positive regulation of L-lysine import across plasma membrane IDA
IDA: Inferred from direct assay
7499219 RGD
involved in positive regulation of blood pressure IDA
IDA: Inferred from direct assay
11897768 RGD
involved in positive regulation of cardiac muscle cell apoptotic process IDA
IDA: Inferred from direct assay
24465706 RGD
involved in positive regulation of cardiac muscle hypertrophy IDA
IDA: Inferred from direct assay
8348686 RGD
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
22561449 RGD
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
24036592 RGD
involved in positive regulation of extracellular matrix constituent secretion IDA
IDA: Inferred from direct assay
21419085 RGD
involved in positive regulation of fibroblast proliferation IDA
IDA: Inferred from direct assay
8348686 RGD
involved in positive regulation of insulin receptor signaling pathway IDA
IDA: Inferred from direct assay
24184594 RGD
involved in positive regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
18388195 RGD
involved in positive regulation of nitric oxide biosynthetic process IDA
IDA: Inferred from direct assay
17616753 RGD
involved in positive regulation of norepinephrine secretion IDA
IDA: Inferred from direct assay
11100981 RGD
involved in positive regulation of superoxide anion generation IDA
IDA: Inferred from direct assay
21376054 RGD
involved in positive regulation of vascular associated smooth muscle cell migration IDA
IDA: Inferred from direct assay
24595849 RGD
involved in positive regulation of vascular associated smooth muscle cell proliferation IDA
IDA: Inferred from direct assay
24595849 RGD
involved in protein import into nucleus IDA
IDA: Inferred from direct assay
21376054 RGD
involved in regulation of apoptotic process IDA
IDA: Inferred from direct assay
24168260 RGD
involved in regulation of calcium ion transport IDA
IDA: Inferred from direct assay
21423294 RGD
involved in regulation of heart rate IDA
IDA: Inferred from direct assay
11897768 RGD
involved in regulation of long-term neuronal synaptic plasticity IMP
IMP: Inferred from mutant phenotype
11282364 RGD
involved in regulation of transmission of nerve impulse IDA
IDA: Inferred from direct assay
22198171 RGD
involved in renin-angiotensin regulation of aldosterone production IDA
IDA: Inferred from direct assay
21318332 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
18388195 RGD
involved in response to mechanical stimulus IEP
IEP: Inferred from expression pattern
23855625 RGD
involved in response to muscle activity involved in regulation of muscle adaptation IMP
IMP: Inferred from mutant phenotype
8252633 RGD
involved in smooth muscle cell proliferation IDA
IDA: Inferred from direct assay
21292788 RGD
involved in stress-activated MAPK cascade IDA
IDA: Inferred from direct assay
21367774 RGD
involved in uterine smooth muscle contraction IDA
IDA: Inferred from direct assay
21401609 RGD
involved in vasoconstriction IDA
IDA: Inferred from direct assay
20955746 RGD
involved in vasodilation IDA
IDA: Inferred from direct assay
21056585 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
8252633 RGD
NOT located in mitochondrion IDA
IDA: Inferred from direct assay
23959064 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

angiotensinogen

  • angiotensin II

  • angiotensinogen (serpin peptidase inhibitor, clade A, member 8)

  • serpin A8

Recombinant Agt Proteins

Cat. No. Product Name Accession Purity
HY-P73651 Serpin A8/Angiotensinogen Protein, Rat (HEK293, His) P01015 (D25-V477) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Phase
HY-108764 Mipomersen sodium Inhibitor 95.60% Phase 3
HY-W002585 O6-Benzylguanine 99.92% Phase 3
HY-145649 Zilebesiran 95.63% Phase 3
HY-145649A Zilebesiran sodium / Phase 2
HY-147406A Tonlamarsen sodium / Phase 2
HY-19932 MK-2748 Inhibitor / Phase 1
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99530 Valanafusp alfa 98.42% Phase 2
HY-P992048 AGT-182 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (19)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-150738 ODN 2088 Antagonist 98.82% Unkown
HY-143230 Custirsen Inducer 96.12% Unkown
HY-148413 Aprinocarsen sodium Inhibitor 98.42% Unkown
HY-150736 ODN 20844 Inhibitor 96.14% Unkown
HY-150744 ODN 24888 Inhibitor / Unkown
HY-106435 Cystemustine Inhibitor / Unkown
HY-147406 Tonlamarsen / Unkown
HY-150740 ODN 21595 Inhibitor / Unkown
HY-186228 Anticancer agent 333 / Unkown
HY-D2935 CoDi2 / Unkown
HY-D2981 CoDi1 / Unkown
HY-D2995 CoDi3 / Unkown
HY-P5939 Angiotensinogen (1-13) (human) / Unkown
HY-RS00466 AGT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00473 AGXT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08412 Mgmt Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-185922 Baslisiran / Unkown
HY-RS17726 Agt Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24191 Agt Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Agt NCBI NCBI:183