Hgf - hepatocyte growth factor Gene

Also Known as HPTA

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24446

Summary

Enables growth factor activity. Involved in several processes, including animal organ regeneration; positive regulation of angiogenesis; and positive regulation of myelination. Located in extracellular space. Used to study brain infarction. Biomarker of cholangiocarcinoma. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autosomal recessive nonsyndromic deafness 39; eye disease (multiple); neuropathy (multiple); and scleroderma (multiple). Orthologous to human HGF (hepatocyte growth factor). [provided by Alliance of Genome Resources, Apr 2022]

Hgf Products (1)

mRNA Protein Name
NM_017017.2 NP_058713.1 hepatocyte growth factor preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables growth factor activity IMP
IMP: Inferred from mutant phenotype
1826679 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
1826679 RGD
Biological Process GO Annotation Evidence References Source
involved in animal organ regeneration IEP
IEP: Inferred from expression pattern
19638569 RGD
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
16885537 RGD
involved in positive regulation of angiogenesis IDA
IDA: Inferred from direct assay
17549731 RGD
involved in positive regulation of myelination IDA
IDA: Inferred from direct assay
17549731 RGD
involved in positive regulation of neuron projection regeneration IDA
IDA: Inferred from direct assay
17549731 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
19638569 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hepatocyte growth factor

  • SF

  • hepatopoeitin-A

  • hepatopoietin-A

  • scatter factor

Recombinant Hgf Proteins

Cat. No. Product Name Accession Purity
HY-P71688 HGF Protein, Rat (GST) P17945 (T477-L728) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P73101 HGF Protein, Rat (HEK293) NP_058713.1 (Q33-L728) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-A0020 Eldecalcitol 99.94% Yes

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-137455 Terevalefim Activator 99.37% Phase 3
HY-18696 AMG-337 99.40% Phase 2
Inhibitory Antibodies (7)
Cat. No. Product Name Effect
Purity Phase
HY-P99391 Telisotuzumab 99.91% Phase 3
HY-P99250 Onartuzumab Inhibitor 99.62% Phase 3
HY-P99196 Ficlatuzumab Inhibitor 96.54% Phase 3
HY-P99217 Rilotumumab Inhibitor 99.10% Phase 3
HY-P99192 Emibetuzumab Inhibitor 95.00% Phase 2
HY-P990949 Umikibart 98.70% Phase 2
HY-P991660 ARGX-111 Inhibitor 99.25% Phase 1

Pre-clinical Phase

Bioactive Molecules (38)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-16969 Dihexa Activator 98.92% Unkown
HY-106961 ONO 1301 Agonist 99.02% Unkown
HY-114363A SRI 31215 TFA Inhibitor 98.35% Unkown
HY-12017 PF-04217903 99.85% Unkown
HY-P1415A Norleual TFA 99.52% Unkown
HY-12017A PF-04217903 mesylate 99.82% Unkown
HY-176901 HGF-IN-1 Inhibitor 98.01% Unkown
HY-106961A (Z)-ONO 1301 Agonist 98.13% Unkown
HY-145263 VD2173 Inhibitor / Unkown
HY-154988 MARK4 inhibitor 4 99.23% Unkown
HY-RS13576 SOS1 Human Pre-designed siRNA Set A / Unkown
HY-N13286 Glycozolidal Inhibitor 99.92% Unkown
HY-12017B PF-04217903 phenolsulfonate / Unkown
HY-10338A Foretinib phosphate Inhibitor / Unkown
HY-114363 SRI 31215 Inhibitor / Unkown
HY-120159 GS-493 Inhibitor / Unkown
HY-165284 CM-118 Inhibitor / Unkown
HY-E70748 MET D1228H Recombinant Human Active Protein Kinase / Unkown
HY-E70749 MET D1228N Recombinant Human Active Protein Kinase / Unkown
HY-E70750 MET F1200I Recombinant Human Active Protein Kinase / Unkown
HY-E70751 MET G1163R Recombinant Human Active Protein Kinase / Unkown
HY-E70752 MET L1195V Recombinant Human Active Protein Kinase / Unkown
HY-E70753 MET M1250T Recombinant Human Active Protein Kinase / Unkown
HY-E70754 MET Y1230A Recombinant Human Active Protein Kinase / Unkown
HY-E70755 MET Y1230C Recombinant Human Active Protein Kinase / Unkown
HY-E70756 MET Y1230D Recombinant Human Active Protein Kinase / Unkown
HY-E70757 MET Y1230H Recombinant Human Active Protein Kinase / Unkown
HY-E70758 MET Y1235D Recombinant Human Active Protein Kinase / Unkown
HY-N17359 Mulberrofuran W / Unkown
HY-N17854 3β-O-α-L-Arabinopyranosylsiaresinolic acid 28-O-β-D-glucopyranosyl ester / Unkown
HY-P1415 Norleual / Unkown
HY-RS06152 HGF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06774 IL6 Human Pre-designed siRNA Set A / Unkown
HY-RS08346 Met Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-12017C PF-04217903 phosphate / Unkown
HY-174670 Human HGF mRNA / Unkown
HY-RS16504 Hgf Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22936 Hgf Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991589 SFN68 Inhibitor 99.87% Unkown
HY-P991565 CE-355621 Inhibitor / Unkown
HY-P992396 KTN0073 Inhibitor / Unkown
HY-P99391A Telisotuzumab (powder) / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hgf NCBI NCBI:3082