Optn - optineurin Gene

Also Known as Fip2

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 246294

Summary

Enables TFIIIA-class transcription factor binding activity; identical protein binding activity; and ubiquitin binding activity. Involved in several processes, including cellular response to L-glutamate; cellular response to tumor necrosis factor; and regulation of neuron apoptotic process. Located in several cellular components, including axon; neuronal cell body; and perinuclear region of cytoplasm. Colocalizes with Golgi apparatus. Biomarker of Parkinson's disease; bladder neck obstruction; proteinuria; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Paget's disease of bone; amyotrophic lateral sclerosis (multiple); and glaucoma (multiple). Orthologous to human OPTN (optineurin). [provided by Alliance of Genome Resources, Apr 2022]

Optn Products (1)

mRNA	Protein	Name
NM_145081.4	NP_659549.3	optineurin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables TFIIIA-class transcription factor binding	IPI IPI: Inferred from physical interaction	10756201	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	20161783	RGD
enables ubiquitin binding	IDA IDA: Inferred from direct assay	21059646	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in Golgi organization	IMP IMP: Inferred from mutant phenotype	15837803	RGD
involved in cellular response to L-glutamate	IEP IEP: Inferred from expression pattern	28761318	RGD
involved in cellular response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	28776281	RGD
involved in cellular response to nerve growth factor stimulus	IEP IEP: Inferred from expression pattern	17663725	RGD
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	28776281	RGD
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	28776281	RGD
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	22194658	RGD
involved in neural retina development	IEP IEP: Inferred from expression pattern	17687037	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	22194658	RGD
involved in positive regulation of cytokine production	IMP IMP: Inferred from mutant phenotype	28776281	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	22194658	RGD
involved in positive regulation of neural precursor cell proliferation	IMP IMP: Inferred from mutant phenotype	22194658	RGD
involved in positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	25385380	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	15837803	RGD
located in axon	IDA IDA: Inferred from direct assay	28761318	RGD
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	15837803	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	28761318	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	28776281	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
optineurin	14.7K-interacting protein 2 FIP-2-like protein

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-165298	DGY-09-192		99.50%	Unkown
HY-RS09809	OPTN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18146	Optn Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24621	Optn Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Optn	NCBI	NCBI:10133