Pkd1 - polycystin 1, transient receptor potential channel interacting Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24650

About Pkd1

Primary_assembly 10: 13,573,021-13,621,128 forward strand.mRatBN7.2:CM026983.1

This gene has 2 transcripts (splice variants), 194 orthologues, 10 paralogues and is associated with 30 phenotypes. Biased expression in Lung (RPKM 191.2), Heart (RPKM 147.1) and 9 other tissues.

Summary

Predicted to enable several functions, including Wnt-activated receptor activity; protein kinase binding activity; and transmembrane transporter binding activity. Predicted to contribute to Calcium Channel activity. Involved in positive regulation of cytosolic calcium ion concentration. Located in Golgi apparatus and lateral plasma membrane. Used to study polycystic kidney disease. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; intracranial aneurysm; and polycystic kidney disease 1. Orthologous to human PKD1 (polycystin 1, transient receptor potential channel interacting). [provided by Alliance of Genome Resources, Apr 2022]

Pkd1 Products (1)

mRNA Protein Name
NM_001414013.1 NP_001400942.1 polycystin-1 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in positive regulation of cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
16952559 RGD
Cellular Component GO Annotation Evidence References Source
located in lateral plasma membrane IDA
IDA: Inferred from direct assay
11336705 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pkd1 Protein Structure

LRRNT

LRRNT: smart00013 (31 - 70)

LRR_8

LRR_8: pfam13855 (60 - 126)

LRR_1

LRR_1: sd00031 (69 - 91)

LRR_1

LRR_1: sd00031 (92 - 115)

PCC

PCC: cl28216 (96 - 2721)

LRR_1

LRR_1: sd00031 (116 - 128)

GPS

GPS: cl02559 (3001 - 3050)

PLAT_polycystin

PLAT_polycystin: cd01752 (3108 - 3227)

PKD_channel

PKD_channel: cl37568 (3701 - 4101)

  • 0
  • 700
  • 1400
  • 2100
  • 2800
  • 3500
  • 4292 a.a.
Protein Preferred Names Protein Names

polycystin-1

  • polycystic kidney disease 1 homolog

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-15698 CRT0066101 Inhibitor 99.88% Phase 1

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13687 IKK 16 Inhibitor 99.88% Unkown
HY-15698A CRT0066101 dihydrochloride Inhibitor 99.97% Unkown
HY-13941 1-Naphthyl PP1 Inhibitor 99.36% Unkown
HY-13687A IKK 16 hydrochloride Inhibitor 99.95% Unkown
HY-12239 CID755673 Inhibitor 99.13% Unkown
HY-118052 BPKDi Inhibitor 99.74% Unkown
HY-13454 CID 2011756 Inhibitor 96.98% Unkown
HY-15528 kb NB 142-70 Inhibitor 98.02% Unkown
HY-128142 PKC/PKD-IN-1 Inhibitor 98.35% Unkown
HY-151374 3-IN-PP1 Inhibitor 99.37% Unkown
HY-15698B CRT0066101 trihydrochloride Inhibitor / Unkown
HY-151372 Protein kinase D inhibitor 1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pkd1 NCBI NCBI:5310