Prkca - protein kinase C, alpha Gene

Also Known as Pkca

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24680

About Prkca

Primary_assembly 10: 92,894,012-93,288,012 reverse strand.mRatBN7.2:CM026983.1

This gene has 5 transcripts (splice variants), 284 orthologues, 9 paralogues and is associated with 26 phenotypes. Biased expression in Muscle (RPKM 146.), Brain (RPKM 14.7) and 9 other tissues.

Summary

Enables calcium-dependent protein kinase C activity. Involved in several processes, including positive regulation of ERK1 and ERK2 cascade; protein phosphorylation; and regulation of vesicle-mediated transport. Located in several cellular components, including membrane raft; mitochondrion; and perinuclear region of cytoplasm. Part of protein-containing complex. Used to study hypertension. Biomarker of brain ischemia; congestive heart failure; and ischemia. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; high grade glioma (multiple); large cell carcinoma; and reproductive organ Cancer (multiple). Orthologous to human PRKCA (protein kinase C alpha). [provided by Alliance of Genome Resources, Apr 2022]

Prkca Products (1)

mRNA Protein Name
NM_001399299.1 NP_001386228.1 protein kinase C alpha type

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium,diacylglycerol-dependent serine/threonine kinase activity IDA
IDA: Inferred from direct assay
9046017 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9514928 RGD
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
15272003 RGD
Biological Process GO Annotation Evidence References Source
involved in central nervous system neuron axonogenesis IMP
IMP: Inferred from mutant phenotype
18062921 RGD
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
11562372 RGD
involved in learning or memory IMP
IMP: Inferred from mutant phenotype
18073185 RGD
involved in negative regulation of translation IMP
IMP: Inferred from mutant phenotype
16556598 RGD
involved in peptidyl-threonine phosphorylation IMP
IMP: Inferred from mutant phenotype
16717194 RGD
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
11864993 RGD
involved in positive regulation of cardiac muscle hypertrophy IDA
IDA: Inferred from direct assay
11864993 RGD
involved in positive regulation of exocytosis IMP
IMP: Inferred from mutant phenotype
17408632 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
17908462 RGD
involved in positive regulation of synapse assembly IMP
IMP: Inferred from mutant phenotype
18073185 RGD
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
18972403 RGD
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
9705215 RGD
involved in response to corticosterone IEP
IEP: Inferred from expression pattern
17873323 RGD
involved in response to estradiol IMP
IMP: Inferred from mutant phenotype
18166159 RGD
involved in response to ethanol IMP
IMP: Inferred from mutant phenotype
17408632 RGD
involved in response to mechanical stimulus IEP
IEP: Inferred from expression pattern
17487266 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
17845534 RGD
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
17640386 RGD
involved in response to phorbol 13-acetate 12-myristate IDA
IDA: Inferred from direct assay
15272003 RGD
involved in response to reactive oxygen species IMP
IMP: Inferred from mutant phenotype
17905752 RGD
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
17728094 RGD
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
11864993 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
11864993 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
11007882 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Prkca Protein Structure

C1_cPKC_rpt1

C1_cPKC_rpt1: cd20833 (34 - 91)

C1_cPKC_rpt2

C1_cPKC_rpt2: cd20836 (101 - 154)

C2_PKC_alpha_gamma

C2_PKC_alpha_gamma: cd04026 (158 - 288)

PKc_like

PKc_like: cl21453 (327 - 717)

  • 0
  • 200
  • 400
  • 600
  • 722 a.a.
Protein Preferred Names Protein Names

protein kinase C alpha type

  • PKC-A

  • PKC-alpha

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11116 PRKCA Human Pre-designed siRNA Set A / Unkown
HY-RS11117 Prkca Mouse Pre-designed siRNA Set A / Unkown
HY-RS11118 Prkca Rat Pre-designed siRNA Set A / Unkown
HY-174543 Human PRKCA mRNA / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prkca NCBI NCBI:5578