Prl - prolactin Gene

Also Known as Gha1; PRLB; Prol; PRLSD1; Prl1a1; RNPROL; RATPRLSD1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24683

Summary

Predicted to enable hormone activity and Prolactin receptor binding activity. Involved in several processes, including parturition; response to estradiol; and response to lipopolysaccharide. Located in extracellular region and secretory granule. Used to study portal hypertension and prolactinoma. Biomarker of hyperprolactinemia; prolactinoma; and renovascular hypertension. Human ortholog(s) of this gene implicated in carotid artery disease. Orthologous to human PRL (Prolactin). [provided by Alliance of Genome Resources, Apr 2022]

Prl Products (1)

mRNA Protein Name
NM_012629.1 NP_036761.1 prolactin precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in cellular response to ethanol IEP
IEP: Inferred from expression pattern
28710248 RGD
involved in cellular response to hormone stimulus IEP
IEP: Inferred from expression pattern
17873321 RGD
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
17726143 RGD
involved in multicellular organismal response to stress IEP
IEP: Inferred from expression pattern
17573075 RGD
involved in ovulation cycle IEP
IEP: Inferred from expression pattern
17499646 RGD
involved in parturition IEP
IEP: Inferred from expression pattern
17641097 RGD
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
17640386 RGD
involved in positive regulation of epithelial cell proliferation IDA
IDA: Inferred from direct assay
11751614 RGD
involved in regulation of ossification IMP
IMP: Inferred from mutant phenotype
17218965 RGD
involved in response to alcohol IEP
IEP: Inferred from expression pattern
26509893 RGD
involved in response to cocaine IEP
IEP: Inferred from expression pattern
10871318 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
17122082 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
17526938 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
17706967 RGD
involved in response to macrophage colony-stimulating factor IEP
IEP: Inferred from expression pattern
24882100 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
17447162 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
17190974 RGD
involved in response to trichostatin A IEP
IEP: Inferred from expression pattern
26509893 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
17581744 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular region IDA
IDA: Inferred from direct assay
12193569 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
24882100 RGD
located in secretory granule IDA
IDA: Inferred from direct assay
17341846 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

prolactin

  • growth hormone a1

  • prolactin family 1, subfamily a, member 1

Recombinant Prl Proteins

Cat. No. Product Name Accession Purity
HY-P71916A Prolactin Protein, Rat (His) P01237 (L30-C226) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0537 Pentamidine Inhibitor 97.19% Unkown
HY-B0537B Pentamidine isethionate Inhibitor 99.95% Yes
HY-U00051 Propiomazine 98.91% Unkown
HY-B0537C Pentamidine dimesylate Inhibitor / Unkown
HY-U00051A Propiomazine hydrochloride Inhibitor / Unkown
HY-B0537A Pentamidine dihydrochloride Inhibitor / Unkown

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P991358 XOMA-213 Inhibitor 98.46% Phase 1

Pre-clinical Phase

Bioactive Molecules (20)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-112476 PRL-3 Inhibitor I Inhibitor 98.11% Unkown
HY-128153 Thienopyridone 95.14% Unkown
HY-P4452 PRL 2915 99.92% Unkown
HY-131547 Org OD 02-0 99.7% Unkown
HY-103079 PRL-3 Inhibitor 2 Inhibitor 99.12% Unkown
HY-B0537AS Pentamidine-d4 dihydrochloride Inhibitor 98.49% Unkown
HY-P4469 PRL 3195 / Unkown
HY-W043170 PRL3-CNNM4 PPI-IN-1 Inhibitor 99.33% Unkown
HY-13976A PRL-8-53 / Unkown
HY-162119 PRL-IN-1 Inhibitor / Unkown
HY-171035 PRL-295 Inhibitor / Unkown
HY-P4523 FA-Ala-Arg / Unkown
HY-RS11160 PRL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-U00051AS Propiomazine-d6 hydrochloride Inhibitor / Unkown
HY-U00051AS1 (R)-Propiomazine-d6 hydrochloride / Unkown
HY-U00051AS2 (S)-Propiomazine-d6 hydrochloride / Unkown
HY-U00051B Propiomazine maleate / Unkown
HY-114877 CG-707 Inhibitor / Unkown
HY-RS16777 Prl Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23217 Prl Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prl NCBI NCBI:5617