PRL-8-53
PRL-8-53 is an orally active, blood-brain barrier-permeable benzoate derivative with potent spasmolytic activity and central nervous system regulatory activity. PRL-8-53 acts on dopamine, serotonin and cholinergic-related targets, enhances dopamine activity, partially inhibits serotonin function and elicits cholinergic responses, thereby maintaining neurotransmitter balance in the central nervous system. PRL-8-53 improves learning ability, short-term memory and long-term memory in animals. PRL-8-53 can be used in central nervous system-related research.
For research use only. We do not sell to patients.
- CAS No.: 51352-87-5
- Formula: C18H22ClNO2
- Molecular Weight:319.83
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
PRL-8-53 modulates dopamine, serotonin and cholinergic targets, potentiates dopamine activity, partially inhibits serotonin function and triggers cholinergic responses in experimental animals[1][2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
PRL-8-53 does not alter d-amphetamine stimulant effects or avoidance rate in rats at tested doses, reverses reserpine-induced catatonia and ptosis, and does not induce stereotypic behavior at doses up to 200 mg/kg[1].
PRL-8-53 does not significantly alter blood pressure in normotensive dogs at doses up to 8 mg/kg[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 51352-87-5
-
Molecular Weight 319.83
-
Formula C18H22ClNO2
-
SMILES
O=C(C1=CC=CC(CCN(CC2=CC=CC=C2)C)=C1)OC.Cl
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz