Propiomazine hydrochloride 

Propiomazine hydrochloride is an orally active antihistamine agent. Propiomazine hydrochloride is a potent prolactin (PRL) release stimulant, whose effect depends on the antagonism of the dopaminergic system and can inhibit the secretion of luteinizing hormone (LH). Propiomazine hydrochloride is mainly used for anesthesia assistance, mental disorders and anxiety-induced sedation, and can also be used in research related to insomnia^[1][2][3][4].

Propiomazine (0.2 mg/kg, nasal administration, rats) hydrochloride is quickly absorbed, followed by rapid reduction of the plasma concentrations^[3].
Propiomazine (25 mg/kg, i.p., at 0 and 3 h after challenge) hydrochloride protects rats against CCl₄-induced hepatic injury^[4].
Propiomazine (0.31-20 mg/kg, i.v.) hydrochloride increases plasma prolactin concentrations in rats^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

376.94

C₂₀H₂₅ClN₂OS

1240-15-9

CCC(C1=CC=C(SC2=C3C=CC=C2)C(N3CC(C)N(C)C)=C1)=O.[H]Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. B Midgren, et al. Effects of single doses of propiomazine, a phenothiazine hypnotic, on sleep and oxygenation in patients with stable chronic obstructive pulmonary disease. Respiration. 1990;57(4):239-42.  [Content Brief]

  [2]. Thunander Sundbom L, etal. Sedating antihistamines - risk of severe intoxication. Lakartidningen. 2021 Sep 30;118:21037.  [Content Brief]

  [3]. C.Bjerre, et al. Bioavailability of the sedative propiomazine after nasal administration in rats. International Journal of Pharmaceutics, 1996, 144 (2), 217-224.

  [4]. Fayez M, et al. Effect of propiomazine on plasma prolactin in the rat: counteraction by L-dopa. Proc Soc Exp Biol Med. 1985 Apr;178(4):606-9.  [Content Brief]