Thy1 - Thy-1 cell surface antigen Gene

Also Known as CD7

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24832

Summary

Enables GPI anchor binding activity; GTPase activator activity; and protein kinase binding activity. Involved in several processes, including T cell receptor signaling pathway; focal adhesion assembly; and negative regulation of neuron projection development. Located in several cellular components, including growth cone; neuron projection membrane; and neuronal cell body membrane. Is anchored component of plasma membrane. Biomarker of retinal disease and retinal ischemia. Orthologous to human THY1 (Thy-1 cell surface antigen). [provided by Alliance of Genome Resources, Apr 2022]

Thy1 Products (1)

mRNA Protein Name
NM_012673.2 NP_036805.1 thy-1 membrane glycoprotein preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GPI anchor binding IDA
IDA: Inferred from direct assay
16257296 RGD
enables GTPase activator activity IDA
IDA: Inferred from direct assay
15093746 RGD
enables enzyme binding IPI
IPI: Inferred from physical interaction
8666426 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
10814697 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
8870703 RGD
Biological Process GO Annotation Evidence References Source
involved in T cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
9285719 RGD
involved in cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
9285719 RGD
acts upstream of or within positive effect cell-cell signaling IDA
IDA: Inferred from direct assay
22479590 RGD
involved in cytoskeleton organization IDA
IDA: Inferred from direct assay
15093746 RGD
involved in focal adhesion assembly IDA
IDA: Inferred from direct assay
15093746 RGD
involved in negative regulation of axonogenesis IDA
IDA: Inferred from direct assay
15547945 RGD
involved in negative regulation of cell migration IDA
IDA: Inferred from direct assay
15093746 RGD
acts upstream of or within positive effect negative regulation of neuron projection regeneration IMP
IMP: Inferred from mutant phenotype
22479590 RGD
involved in negative regulation of protein kinase activity IDA
IDA: Inferred from direct assay
15093746 RGD
involved in positive regulation of GTPase activity IDA
IDA: Inferred from direct assay
15093746 RGD
involved in positive regulation of T cell activation IDA
IDA: Inferred from direct assay
7722293 RGD
involved in positive regulation of release of sequestered calcium ion into cytosol IDA
IDA: Inferred from direct assay
2873512 RGD
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
19723805 RGD
involved in receptor clustering IDA
IDA: Inferred from direct assay
22479590 RGD
involved in response to axon injury IEP
IEP: Inferred from expression pattern
20187850 RGD
Cellular Component GO Annotation Evidence References Source
located in axolemma IDA
IDA: Inferred from direct assay
22479590 RGD
located in cell surface IDA
IDA: Inferred from direct assay
15474526 RGD
located in cytosol IDA
IDA: Inferred from direct assay
15547945 RGD
located in dendrite membrane IDA
IDA: Inferred from direct assay
22479590 RGD
located in growth cone IDA
IDA: Inferred from direct assay
10601014 RGD
located in membrane raft IDA
IDA: Inferred from direct assay
14499952 RGD
located in neuronal cell body membrane IDA
IDA: Inferred from direct assay
22479590 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
15547945 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

thy-1 membrane glycoprotein

  • CD90

  • Thy-1 protein

  • Thymus cell surface antigen

  • thy-1 antigen

  • thy-1 glycoprotein

  • thymus cell antigen 1, theta

Recombinant Thy1 Proteins

Cat. No. Product Name Accession Purity
HY-P74514 Thy1/CD90 Protein, Rat (HEK293, His) P01830 (Q20-K129) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12953 R-268712 Inhibitor 99.92% Unkown
HY-117738 Benarthin Inhibitor 95.79% Unkown
HY-RS14511 THY1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-106611 Brinazarone Inhibitor / Unkown
HY-RS17457 Thy1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23914 Thy1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990157 Anti-Mouse Thy1/CD90 Antibody (M5/49.4.1) Inhibitor 95.00% Unkown
HY-P990156 Anti-Mouse Thy1.1/CD90.1 Antibody (19E12) Inhibitor 95.00% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Thy1 NCBI NCBI:7070