Wt1 - WT1 transcription factor Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24883

Summary

This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It plays an essential role in the normal development of the urogenital system, and the human gene is mutated in a small subset of patients with Wilm's tumors. Authors of PMID:7926762 provide evidence that Wt1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Jul 2008]

Wt1 Products (1)

mRNA Protein Name
NM_031534.2 NP_113722.2 Wilms tumor protein homolog

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
8389468 RGD
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
11071895 RGD
Biological Process GO Annotation Evidence References Source
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
8389468 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
11071895 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

Wilms tumor protein homolog

  • Wilms tumor 1

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14872 Tideglusib Inhibitor 99.70% Yes

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-104036 IDH-305 Inhibitor 99.15% Phase 2
HY-P11084 WT1 126-134 peptide 98.89% Phase 2

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-122913 Borussertib Inhibitor 99.18% Unkown
HY-W143698 PDGFRα kinase inhibitor 2 Inhibitor 98.95% Unkown
HY-RS17032 Wt1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P11084A WT1 126-134 peptide acetate 99.12% Unkown
HY-RS15853 WT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-120765 BRD2879 Inhibitor / Unkown
HY-RS23476 Wt1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99650 Grisnilimab Inhibitor 99.43% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Wt1 NCBI NCBI:7490