Il4r - interleukin 4 receptor Gene

Also Known as Il4ra

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25084

Summary

Predicted to enable cytokine receptor activity. Involved in several processes, including ovulation; response to estrogen; and response to odorant. Located in extracellular space. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in several diseases, including acne; allergic conjunctivitis; autoimmune disease (multiple); human immunodeficiency virus infectious disease; and renal tuberculosis. Orthologous to human IL4R (interleukin 4 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Il4r Products (1)

mRNA Protein Name
NM_133380.2 NP_596871.2 interleukin-4 receptor subunit alpha precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in regulation of cell population proliferation IDA
IDA: Inferred from direct assay
10525162 RGD
involved in response to estrogen IEP
IEP: Inferred from expression pattern
17652031 RGD
involved in response to odorant IEP
IEP: Inferred from expression pattern
23103411 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
10525162 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interleukin-4 receptor subunit alpha

  • IL-4 receptor subunit alpha

  • IL-4R subunit alpha

  • IL-4R-alpha

  • IL-4RA

  • interleukin 4 receptor, alpha

  • interleukin-4 receptor alpha chain

Recombinant Il4r Proteins

Cat. No. Product Name Accession Purity
HY-P73217 IL-4R alpha/CD124 Protein, Rat (HEK293, His) Q63257-1 (I26-R232) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74801 IL-4R alpha/CD124 Protein, Rat (HEK293, Fc) Q63257-1 (I26-R232) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9926 Dupilumab Inhibitor ≥99.2% Unkown
HY-P99025 Lebrikizumab Inhibitor 99.90% Unkown

Clinical Phase

Inhibitory Antibodies (6)
Cat. No. Product Name Effect
Purity Phase
HY-P990093 Stapokibart Inhibitor 99.37% Phase 4
HY-P990090 Rademikibart Inhibitor 99.13% Phase 3
HY-P99724 Manfidokimab 95.00% Phase 3
HY-P991515 TQH-2722 Inhibitor / Phase 3
HY-P990910 Comekibart Inhibitor 97.43% Phase 2
HY-P991285 MEDI-9314 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P11143 IL4RPep-1 / Unkown
HY-P11143A IL4RPep-1 acetate 98.61% Unkown
HY-RS06769 IL4R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174603 Human IL4R mRNA / Unkown
HY-RS23551 Il4r Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992033 Anti-Mouse IL-4Rα Antibody (REGN1103) Antagonist 99.90% Unkown
HY-P991031 Telikibart Inhibitor 97.505% Unkown
HY-P991152 Oturkibart Inhibitor 99.49% Unkown
HY-P991675 Camtarkibart Inhibitor 99.41% Unkown
HY-P992034 APG808 Inhibitor / Unkown
HY-P991283 AMG-317 Inhibitor / Unkown
HY-P992447 QX008N Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il4r NCBI NCBI:3566