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Abcc2 - ATP binding cassette subfamily C member 2 Gene

Also Known as mrp; Mrp2; cMRP; Cmoat

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 25303

Summary

Enables ABC-type transporter activity; bilirubin transmembrane transporter activity; and protein domain specific binding activity. Involved in several processes, including carboxylic acid transport; cellular response to cytokine stimulus; and cellular response to lipid. Located in brush border membrane and intracellular canaliculus. Used to study Dubin-Johnson syndrome; bilirubin metabolic disorder; cholestasis; end stage renal disease; and visual epilepsy. Biomarker of several diseases, including bilirubin metabolic disorder; fatty liver disease; primary biliary cholangitis; status epilepticus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in bilirubin metabolic disorder (multiple); carcinoma (multiple); drug-induced hepatitis; leukemia (multiple); and non-alcoholic fatty liver disease. Orthologous to human ABCC2 (ATP binding cassette subfamily C member 2). [provided by Alliance of Genome Resources, Apr 2022]

Abcc2 Products (1)

mRNA	Protein	Name
NM_012833.2	NP_036965.1	ATP-binding cassette sub-family C member 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ABC-type glutathione S-conjugate transporter activity	IMP IMP: Inferred from mutant phenotype	10220572	RGD
enables ABC-type xenobiotic transporter activity	IMP IMP: Inferred from mutant phenotype	10220572	RGD
enables bilirubin transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	10421658	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	20404332	RGD
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	19339379	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in antibiotic metabolic process	IMP IMP: Inferred from mutant phenotype	18638490	RGD
involved in benzylpenicillin metabolic process	IMP IMP: Inferred from mutant phenotype	19255943	RGD
involved in bilirubin transport	IMP IMP: Inferred from mutant phenotype	10421658	RGD
involved in canalicular bile acid transport	IMP IMP: Inferred from mutant phenotype	25547484	RGD
involved in cellular response to dexamethasone stimulus	IEP IEP: Inferred from expression pattern	17683490	RGD
involved in cellular response to interleukin-1	IEP IEP: Inferred from expression pattern	20702406	RGD
involved in cellular response to interleukin-6	IEP IEP: Inferred from expression pattern	20702406	RGD
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	20702406	RGD
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	20702406	RGD
involved in cellular response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	27090119	RGD
involved in detoxification of mercury ion	IMP IMP: Inferred from mutant phenotype	23059061	RGD
involved in female pregnancy	IEP IEP: Inferred from expression pattern	15917434	RGD
involved in intracellular chloride ion homeostasis	IDA IDA: Inferred from direct assay	12085350	RGD
involved in leukotriene transport	IMP IMP: Inferred from mutant phenotype	10220572	RGD
involved in mercury ion transport	IMP IMP: Inferred from mutant phenotype	21134393	RGD
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	17437408	RGD
involved in organic anion transport	IMP IMP: Inferred from mutant phenotype	19525466	RGD
involved in prostaglandin transport	IMP IMP: Inferred from mutant phenotype	16584400	RGD
involved in response to antineoplastic agent	IEP IEP: Inferred from expression pattern	21881227	RGD
involved in response to arsenic-containing substance	IEP IEP: Inferred from expression pattern	16737587	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	19299525	RGD
involved in response to estrogen	IDA IDA: Inferred from direct assay	12702498	RGD
involved in response to estrogen	IEP IEP: Inferred from expression pattern	27090119	RGD
involved in response to glucagon	IEP IEP: Inferred from expression pattern	28842383	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	28842383	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	16925582	RGD
involved in response to oxidative stress	IEP IEP: Inferred from expression pattern	16785030	RGD
involved in response to steroid hormone	IEP IEP: Inferred from expression pattern	16483613	RGD
involved in response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	16757538	RGD
involved in thyroid hormone transport	IMP IMP: Inferred from mutant phenotype	19211616	RGD
involved in transepithelial transport	IGI IGI: Inferred from genetic interaction	17437408	RGD
involved in transepithelial transport	IMP IMP: Inferred from mutant phenotype	12663688	RGD
involved in xenobiotic catabolic process	IMP IMP: Inferred from mutant phenotype	18088505	RGD
involved in xenobiotic detoxification by transmembrane export across the plasma membrane	IMP IMP: Inferred from mutant phenotype	16857726	RGD
involved in xenobiotic transmembrane transport	IMP IMP: Inferred from mutant phenotype	10220572	RGD
involved in xenobiotic transport across blood-brain barrier	IGI IGI: Inferred from genetic interaction	17437408	RGD
involved in xenobiotic transport across blood-brain barrier	IMP IMP: Inferred from mutant phenotype	12663688	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	10220572	RGD
located in brush border membrane	IDA IDA: Inferred from direct assay	16899240	RGD
located in intracellular canaliculus	IDA IDA: Inferred from direct assay	19027009	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
ATP-binding cassette sub-family C member 2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2 ATP-binding cassette, subfamily C (CFTR/MRP), member 2 cMrp2/cMoat canalicular apical conjugate export pump calicular multispecific organic anion transporter canalicular multidrug resistance prot

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0488A	Vincristine		98.60%	Yes

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00061	ABCC2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21468	Abcc2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27986	Abcc2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Abcc2	NCBI	NCBI:1244