Star - steroidogenic acute regulatory protein Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25557

Summary

Predicted to enable Cholesterol binding activity. Involved in several processes, including cellular response to organonitrogen compound; response to glucocorticoid; and steroid biosynthetic process. Located in several cellular components, including cytosol; mitochondrial envelope; and neuronal cell body. Biomarker of hypogonadism; hypothyroidism; nephrosis; polycystic ovary syndrome; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia. Orthologous to human STAR (steroidogenic acute regulatory protein). [provided by Alliance of Genome Resources, Apr 2022]

Star Products (1)

mRNA Protein Name
NM_031558.3 NP_113746.1 steroidogenic acute regulatory protein, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12925534 RGD
Biological Process GO Annotation Evidence References Source
involved in bile acid biosynthetic process IDA
IDA: Inferred from direct assay
15382124 RGD
involved in biphenyl metabolic process IEP
IEP: Inferred from expression pattern
19071209 RGD
involved in cellular response to alkaloid IEP
IEP: Inferred from expression pattern
19639602 RGD
involved in cellular response to antibiotic IEP
IEP: Inferred from expression pattern
18655822 RGD
involved in cellular response to cAMP IEP
IEP: Inferred from expression pattern
9832418 RGD
involved in cellular response to cadmium ion IEP
IEP: Inferred from expression pattern
17719163 RGD
involved in cellular response to dexamethasone stimulus IEP
IEP: Inferred from expression pattern
20075416 RGD
involved in cellular response to epinephrine stimulus IEP
IEP: Inferred from expression pattern
11064152 RGD
involved in cellular response to fibroblast growth factor stimulus IEP
IEP: Inferred from expression pattern
17494997 RGD
involved in cellular response to follicle-stimulating hormone stimulus IEP
IEP: Inferred from expression pattern
20810564 RGD
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
18353182 RGD
involved in cellular response to gonadotropin stimulus IEP
IEP: Inferred from expression pattern
11172811 RGD
involved in cellular response to growth hormone stimulus IEP
IEP: Inferred from expression pattern
10098503 RGD
involved in cellular response to insulin stimulus IEP
IEP: Inferred from expression pattern
17023532 RGD
involved in cellular response to interferon-alpha IMP
IMP: Inferred from mutant phenotype
19929576 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
20665543 RGD
involved in cellular response to luteinizing hormone stimulus IEP
IEP: Inferred from expression pattern
17241129 RGD
involved in cellular response to metal ion IEP
IEP: Inferred from expression pattern
18602937 RGD
involved in cellular response to organic cyclic compound IEP
IEP: Inferred from expression pattern
20937274 RGD
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: Inferred from expression pattern
18511507 RGD
involved in cellular response to type II interferon IEP
IEP: Inferred from expression pattern
9564825 RGD
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
19190255 RGD
involved in dibenzo-p-dioxin metabolic process IEP
IEP: Inferred from expression pattern
18637154 RGD
involved in diterpenoid metabolic process IEP
IEP: Inferred from expression pattern
11064152 RGD
involved in estrogen biosynthetic process IMP
IMP: Inferred from mutant phenotype
16579833 RGD
involved in insecticide metabolic process IEP
IEP: Inferred from expression pattern
18401575 RGD
involved in intracellular cholesterol transport IEP
IEP: Inferred from expression pattern
14617579 RGD
involved in male gonad development IEP
IEP: Inferred from expression pattern
18772241 RGD
involved in negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
16579833 RGD
involved in organic acid metabolic process IEP
IEP: Inferred from expression pattern
17400581 RGD
involved in phenol-containing compound metabolic process IEP
IEP: Inferred from expression pattern
18191889 RGD
involved in phthalate metabolic process IEP
IEP: Inferred from expression pattern
16809437 RGD
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
19156851 RGD
involved in positive regulation of neurogenesis IMP
IMP: Inferred from mutant phenotype
16579833 RGD
involved in regulation of neuronal synaptic plasticity IMP
IMP: Inferred from mutant phenotype
16673174 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
20393161 RGD
involved in response to benzoic acid IEP
IEP: Inferred from expression pattern
30476341 RGD
involved in response to corticosterone IEP
IEP: Inferred from expression pattern
18335507 RGD
involved in response to estrogen IEP
IEP: Inferred from expression pattern
19734697 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
16930210 RGD
involved in response to fungicide IEP
IEP: Inferred from expression pattern
16214947 RGD
involved in response to gonadotropin IEP
IEP: Inferred from expression pattern
19929576 RGD
involved in response to herbicide IEP
IEP: Inferred from expression pattern
20667998 RGD
involved in response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
14635199 RGD
involved in response to insecticide IEP
IEP: Inferred from expression pattern
19892000 RGD
involved in response to ionizing radiation IEP
IEP: Inferred from expression pattern
18821396 RGD
involved in response to lead ion IEP
IEP: Inferred from expression pattern
14514953 RGD
involved in response to leptin IEP
IEP: Inferred from expression pattern
11604238 RGD
involved in response to nicotine IEP
IEP: Inferred from expression pattern
20498001 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
16882930 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
19190255 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
16737795 RGD
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
18609294 RGD
involved in response to retinoic acid IEP
IEP: Inferred from expression pattern
30476341 RGD
involved in response to steroid hormone IEP
IEP: Inferred from expression pattern
19961867 RGD
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
20610472 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
16777379 RGD
involved in testosterone biosynthetic process IEP
IEP: Inferred from expression pattern
19883722 RGD
Cellular Component GO Annotation Evidence References Source
located in mitochondrial crista IDA
IDA: Inferred from direct assay
9065457 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
19730783 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

steroidogenic acute regulatory protein, mitochondrial

  • START domain-containing protein 1

  • stARD1

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12502A Efonidipine hydrochloride monoethanolate Inhibitor 99.83% Unkown
HY-12502 Efonidipine Inhibitor 99.88% Unkown
HY-12502AR Efonidipine hydrochloride monoethanolate (Standard) Inhibitor / Unkown
HY-12502B Efonidipine hydrochloride Inhibitor / Unkown

Pre-clinical Phase

Bioactive Molecules (21)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15483 DY131 99.72% Unkown
HY-Y0740 4-Methoxybenzaldehyde 99.80% Unkown
HY-W1048851B 4-Arm-PEG10000-Maleimide 97.0% Unkown
HY-134462 RJW103 Agonist 98.71% Unkown
HY-W073128 Perfluorotetradecanoic acid 98.0% Unkown
HY-D2348 ACE / Unkown
HY-143656 SH379 / Unkown
HY-161384 WJM-715 Inhibitor / Unkown
HY-N12102 Dihydrodehydrodiconiferyl alcohol 9-O-α-L-rhamnopyranoside Inhibitor / Unkown
HY-N12136 1α-Hydroxy-3-deoxypseudoanisatin / Unkown
HY-P10780 RFRP-3 (mouse) 98.82% Unkown
HY-RS02193 CD163L1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05921 GUCY2C Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13875 STAR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W750726 7,8,7’,8’-Tetradehydroastaxanthin / Unkown
HY-Y0740S 4-Methoxybenzaldehyde-d1 / Unkown
HY-Y0740S1 4-Methoxybenzaldehyde-d3 / Unkown
HY-RS18153 Star Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24627 Star Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W721611 Terbucarb / Unkown
HY-Y0740S2 4-Methoxybenzaldehyde-d2 / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992132 Solaprubart Inhibitor 99.59% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Star NCBI NCBI:6770
Canis familiaris Star NCBI NCBI:475588
Macaca fascicularis Star NCBI NCBI:102132972
Mus musculus Star NCBI NCBI:20845