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Pparg - peroxisome proliferator-activated receptor gamma Gene

Also Known as PPARgamma2

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 25664

About Pparg

Primary_assembly 4: 148,423,194-148,548,468 forward strand.mRatBN7.2:CM026977.1

This gene has 2 transcripts (splice variants), 405 orthologues, 19 paralogues and is associated with 103 phenotypes. Biased expression in Thymus (RPKM 11.5), Adrenal (RPKM 13.6) and 7 other tissues.

Summary

Enables several functions, including DNA-binding transcription factor activity; Estrogen receptor binding activity; and protein Phosphatase binding activity. Involved in several processes, including positive regulation of cell differentiation; regulation of cellular macromolecule biosynthetic process; and response to vitamin. Located in cytosol; nucleus; and perinuclear region of cytoplasm. Used to study several diseases, including acute kidney failure; artery disease (multiple); pancreatitis; polycystic kidney disease; and transient cerebral ischemia. Biomarker of several diseases, including alcoholic cardiomyopathy; diabetic encephalopathy; hyperandrogenism; obesity; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); end stage renal disease; lipodystrophy (multiple); obesity; and type 2 diabetes mellitus. Orthologous to human PPARG (peroxisome proliferator activated receptor gamma). [provided by Alliance of Genome Resources, Apr 2022]

Pparg Products (3)

mRNA	Protein	Name
NM_001145366.1	NP_001138838.1	peroxisome proliferator-activated receptor gamma isoform 2
NM_001145367.1	NP_001138839.1	peroxisome proliferator-activated receptor gamma isoform 2
NM_013124.3	NP_037256.1	peroxisome proliferator-activated receptor gamma isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	16257923	RGD
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	19383491	RGD
enables nuclear estrogen receptor binding	IPI IPI: Inferred from physical interaction	20689342	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	18828195	RGD
enables protein phosphatase binding	IDA IDA: Inferred from direct assay	18600431	RGD
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	19383491	RGD
enables transcription coactivator binding	IPI IPI: Inferred from physical interaction	10037764	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in animal organ regeneration	IEP IEP: Inferred from expression pattern	18565023	RGD
involved in cellular response to hyperoxia	IEP IEP: Inferred from expression pattern	22444276	RGD
involved in cellular response to hypoxia	IDA IDA: Inferred from direct assay	29695452	RGD
involved in cellular response to prostaglandin E stimulus	IEP IEP: Inferred from expression pattern	10797535	RGD
involved in cellular response to prostaglandin stimulus	IEP IEP: Inferred from expression pattern	11936221	RGD
involved in cellular response to retinoic acid	IEP IEP: Inferred from expression pattern	10797535	RGD
involved in cellular response to vitamin E	IEP IEP: Inferred from expression pattern	11752099	RGD
involved in fatty acid oxidation	IMP IMP: Inferred from mutant phenotype	17003342	RGD
involved in heart development	IEP IEP: Inferred from expression pattern	15754086	RGD
involved in negative regulation of acute inflammatory response	IMP IMP: Inferred from mutant phenotype	18479673	RGD
acts upstream of or within negative regulation of cardiac muscle hypertrophy in response to stress	IDA IDA: Inferred from direct assay	29695452	RGD
involved in negative regulation of cell growth	IMP IMP: Inferred from mutant phenotype	18600431	RGD
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	16556873	RGD
involved in negative regulation of collagen biosynthetic process	IMP IMP: Inferred from mutant phenotype	16202214	RGD
acts upstream of or within negative regulation of connective tissue replacement involved in inflammatory response wound healing	IDA IDA: Inferred from direct assay	29695452	RGD
acts upstream of negative regulation of gene expression	IGI IGI: Inferred from genetic interaction	28867608	RGD
involved in negative regulation of gene expression	IGI IGI: Inferred from genetic interaction	28867608	RGD
involved in negative regulation of lipid storage	IDA IDA: Inferred from direct assay	29695452	RGD
involved in negative regulation of pancreatic stellate cell proliferation	IMP IMP: Inferred from mutant phenotype	16202214	RGD
acts upstream of negative regulation of smooth muscle cell proliferation	IGI IGI: Inferred from genetic interaction	28867608	RGD
acts upstream of or within positive regulation of adiponectin secretion	IDA IDA: Inferred from direct assay	29695452	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16202214	RGD
involved in positive regulation of fat cell differentiation	IMP IMP: Inferred from mutant phenotype	27910957	RGD
involved in positive regulation of fatty acid oxidation	IMP IMP: Inferred from mutant phenotype	18475159	RGD
involved in positive regulation of oligodendrocyte differentiation	IMP IMP: Inferred from mutant phenotype	18543250	RGD
involved in positive regulation of phagocytosis, engulfment	IMP IMP: Inferred from mutant phenotype	15940641	RGD
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19383491	RGD
involved in regulation of fat cell differentiation	IDA IDA: Inferred from direct assay	10438514	RGD
involved in regulation of lipid metabolic process	IMP IMP: Inferred from mutant phenotype	18621767	RGD
involved in regulation of transcription by RNA polymerase II	IEP IEP: Inferred from expression pattern	10438514	RGD
involved in regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16202214	RGD
involved in response to caffeine	IEP IEP: Inferred from expression pattern	18486259	RGD
involved in response to estrogen	IEP IEP: Inferred from expression pattern	18769493	RGD
involved in response to immobilization stress	IEP IEP: Inferred from expression pattern	15820709	RGD
involved in response to linoleic acid	IEP IEP: Inferred from expression pattern	18304850	RGD
involved in response to lipid	IEP IEP: Inferred from expression pattern	19251397	RGD
involved in response to mechanical stimulus	IEP IEP: Inferred from expression pattern	15572034	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	18520050	RGD
involved in response to starvation	IEP IEP: Inferred from expression pattern	19157823	RGD
involved in response to vitamin A	IEP IEP: Inferred from expression pattern	18384703	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	18846335	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	15774612	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pparg Protein Structure

PPARgamma_N

NR_DBD_Ppar

NR_LBD_PPAR

0
100
200
300
400
505 a.a.

Protein Preferred Names	Protein Names
peroxisome proliferator-activated receptor gamma	PPAR-gamma nuclear receptor subfamily 1 group C member 3 peroxisome proliferator activator receptor, gamma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153344	FX-909	Inhibitor	99.79%	Unkown
HY-153364	FTX-6746	Inhibitor	99.07%	Unkown
HY-160160	BAY-5516	Inhibitor	98.17%	Unkown
HY-W009066	2-Ethylhexyl diphenyl phosphate		94.27%	Unkown
HY-108569	nTZDpa		98.53%	Unkown
HY-160161	BAY-5094	Inhibitor	98.04%	Unkown
HY-RS10925	PPARG Human Pre-designed siRNA Set A		/	Unkown
HY-RS10926	Pparg Mouse Pre-designed siRNA Set A		/	Unkown
HY-121579	L-764406	Agonist	/	Unkown
HY-160159	PPARγ modulator-1	Modulator	/	Unkown
HY-160188	BAY-9683	Modulator	/	Unkown
HY-178447	PPARγ agonist 20		/	Unkown
HY-RS10927	Pparg Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pparg	NCBI	NCBI:5468
Mus musculus	Pparg	NCBI	NCBI:19016