2. Gene
  3. Pparg - peroxisome proliferator-activated receptor gamma Gene

Pparg - peroxisome proliferator-activated receptor gamma Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as PPARgamma2

Gene ID: 25664 | Gene type: protein coding

About Pparg

Primary_assembly 4: 148,423,194-148,548,468 forward strand.mRatBN7.2:CM026977.1

This gene has 2 transcripts (splice variants), 405 orthologues, 19 paralogues and is associated with 103 phenotypes. Biased expression in Thymus (RPKM 11.5), Adrenal (RPKM 13.6) and 7 other tissues.

Summary

Enables several functions, including DNA-binding transcription factor activity; Estrogen Receptor binding activity; and protein Phosphatase binding activity. Involved in several processes, including positive regulation of cell differentiation; regulation of cellular macromolecule biosynthetic process; and response to vitamin. Located in cytosol; nucleus; and perinuclear region of cytoplasm. Used to study several diseases, including acute kidney failure; artery disease (multiple); pancreatitis; polycystic kidney disease; and transient cerebral ischemia. Biomarker of several diseases, including alcoholic cardiomyopathy; diabetic encephalopathy; hyperandrogenism; obesity; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); end stage renal disease; lipodystrophy (multiple); obesity; and type 2 diabetes mellitus. Orthologous to human PPARG (peroxisome proliferator activated receptor gamma). [provided by Alliance of Genome Resources, Apr 2022]

Pparg Products(3)

mRNA Protein Name
NM_001145366.1 NP_001138838.1 peroxisome proliferator-activated receptor gamma isoform 2
NM_001145367.1 NP_001138839.1 peroxisome proliferator-activated receptor gamma isoform 2
NM_013124.3 NP_037256.1 peroxisome proliferator-activated receptor gamma isoform 1

Pparg Protein Structure

PPARgamma_N

PPARgamma_N: pfam12577 (30 - 107)

NR_DBD_Ppar

NR_DBD_Ppar: cd06965 (137 - 220)

NR_LBD_PPAR

NR_LBD_PPAR: cd06932 (236 - 503)

  • 0
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  • 200
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  • 400
  • 505 a.a.
Protein Preferred Names Protein Names

peroxisome proliferator-activated receptor gamma

PPAR-gamma

nuclear receptor subfamily 1 group C member 3

peroxisome proliferator activator receptor, gamma

Related Agents

Pre-clinical Phase
Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-153344 FX-909 Inhibitor 98.80% Unkown
HY-160160 BAY-5516 Inhibitor / Unkown
HY-160161 BAY-5094 Inhibitor / Unkown
HY-153364 FTX-6746 Inhibitor 98.68% Unkown
HY-108569 nTZDpa / Unkown
HY-160159 PPARγ modulator-1 Modulator / Unkown
HY-160188 BAY-9683 Modulator / Unkown
HY-RS10925 PPARG Human Pre-designed siRNA Set A / Unkown
HY-RS10926 Pparg Mouse Pre-designed siRNA Set A / Unkown
HY-RS10927 Pparg Rat Pre-designed siRNA Set A / Unkown
HY-N12840 Logmalicid B / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pparg NCBI NCBI:5468