SHC2 - SHC adaptor protein 2 Gene

Homo sapiens

Also known as SCK; SLI; SHCB

Gene ID: 25759 | Gene type: protein coding

About SHC2

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:416,589-461,033 (from NCBI)

This gene has 6 transcripts (splice variants) and 10 orthologues. Ubiquitous expression in prostate (RPKM 10.2), gall bladder (RPKM 9.1) and 24 other tissues.

Summary

Predicted to enable receptor tyrosine kinase binding activity. Predicted to be involved in transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to be located in cytosol. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SHC2 Products(2)

mRNA	Protein	Name
NM_001387056.1	NP_001373985.1	SHC-transforming protein 2 isoform 2
NM_012435.3	NP_036567.2	SHC-transforming protein 2 isoform 1

SHC2 Protein Structure

PID

SH2

0
100
200
300
400
500
582 a.a.

Protein Preferred Names

Protein Names

SHC-transforming protein 2

SH2 domain protein C2

Related Diseases

Diseases

Alias

Skeletal Tuberculosis

Tuberculosis, Osteoarticular

Osteoarticular Tuberculosis

Vaginal Discharge

Seckel Syndrome 1

SCKL1	Nanocephalic Dwarfism
Microcephalic Primordial Dwarfism I	Seckel-Type Dwarfism
Bird-Headed Dwarfism	Sckl
Seckel Syndrome, Type 1	Seckel Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12857	SHC2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SHC2	VGNC	VGNC:65118
Mus musculus	SHC2	MGD	MGI:106180
Bos taurus	SHC2	VGNC	VGNC:55307
Rattus norvegicus	SHC2	RGD	RGD:1307137