SHC2 - SHC adaptor protein 2 Gene

Also Known as SCK; SLI; SHCB

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 25759

About SHC2

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:416,589-461,033 (from NCBI)

This gene has 6 transcripts (splice variants) and 10 orthologues. Ubiquitous expression in prostate (RPKM 10.2), gall bladder (RPKM 9.1) and 24 other tissues.

Summary

Predicted to enable receptor tyrosine kinase binding activity. Predicted to be involved in transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to be located in cytosol. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SHC2 Products (2)

mRNA Protein Name
NM_001387056.1 NP_001373985.1 SHC-transforming protein 2 isoform 2
NM_012435.3 NP_036567.2 SHC-transforming protein 2 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16273093 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SHC2 Protein Structure

PID

PID: Phosphotyrosine interaction domain (PTB/PID) (153 - 307)

SH2

SH2: SH2 domain (487 - 558)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 582 a.a.
Protein Preferred Names Protein Names

SHC-transforming protein 2

  • SH2 domain protein C2

SHC2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SHC2 P98077 MET Homo sapiens P08581
FPS
24728074
Intra
SHC2 P98077 KIT Homo sapiens P10721
FPS
24728074
Intra
SHC2 P98077 EGFR Homo sapiens P00533
Protein Array
16273093
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Skeletal Tuberculosis

  • Tuberculosis, Osteoarticular

  • Osteoarticular Tuberculosis
Vaginal Discharge
Seckel Syndrome 1

  • SCKL1

  • Nanocephalic Dwarfism

  • Microcephalic Primordial Dwarfism I

  • Seckel-Type Dwarfism

  • Bird-Headed Dwarfism

  • Sckl

  • Seckel Syndrome, Type 1

  • Seckel Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12857 SHC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SHC2 VGNC VGNC:65118
Mus musculus SHC2 MGD MGI:106180
Bos taurus SHC2 VGNC VGNC:55307
Rattus norvegicus SHC2 RGD RGD:1307137
Others SHC2 NCBI