IFFO1 - intermediate filament family orphan 1 Gene

Also Known as IFFO; HOM-TES-103

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 25900

Summary

This gene is a member of the intermediate filament family. Intermediate filaments are proteins which are primordial components of the Cytoskeleton and nuclear envelope. The proteins encoded by the members of this gene family are evolutionarily and structurally related but have limited sequence homology, with the exception of the central rod domain. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Ubiquitous expression in spleen (RPKM 12.7), lymph node (RPKM 8.2) and 24 other tissues.

IFFO1 Products (5)

mRNA Protein Name
NM_001039670.3 NP_001034759.1 non-homologous end joining factor IFFO1 isoform 4
NM_001193457.2 NP_001180386.1 non-homologous end joining factor IFFO1 isoform 5
NM_001330324.2 NP_001317253.1 non-homologous end joining factor IFFO1 isoform 7
NM_001330325.2 NP_001317254.1 non-homologous end joining factor IFFO1 isoform 8
NM_080730.5 NP_542768.2 non-homologous end joining factor IFFO1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA double-strand break attachment to nuclear envelope IDA
IDA: Inferred from direct assay
31548606 GOA
involved in double-strand break repair via nonhomologous end joining IMP
IMP: Inferred from mutant phenotype
31548606 GOA
involved in protein localization to site of double-strand break IMP
IMP: Inferred from mutant phenotype
31548606 GOA
Cellular Component GO Annotation Evidence References Source
located in nuclear matrix IDA
IDA: Inferred from direct assay
31548606 GOA
located in nucleoplasm IDA
IDA: Inferred from direct assay
31548606 GOA
located in site of double-strand break IDA
IDA: Inferred from direct assay
31548606 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IFFO1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
IFFO1 Q0D2I5 LMNA Homo sapiens P02545-2
Anti Tag CoIP
31548606
Cross: Cross-species interaction Intra: Intraspecies interaction