CLIP3 - CAP-Gly domain containing linker protein 3 Gene

Also Known as RSNL1; CLIPR59; CLIPR-59

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 25999

About CLIP3

Cytogenetic location: 19q13.12 Genomic coordinates (GRCh38): 19:36,014,660-36,032,873 (from NCBI)

This gene has 6 transcripts (splice variants), 181 orthologues and 4 paralogues. Biased expression in brain (RPKM 97.6), endometrium (RPKM 19.6) and 9 other tissues.

Summary

This gene encodes a member of the cytoplasmic linker protein 170 family. Members of this protein family contain a cytoskeleton-associated protein glycine-rich domain and mediate the interaction of microtubules with cellular organelles. The encoded protein plays a role in T cell Apoptosis by facilitating the association of tubulin and the lipid raft ganglioside GD3. The encoded protein also functions as a scaffold protein mediating membrane localization of phosphorylated protein kinase B. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]

CLIP3 Products (2)

mRNA	Protein	Name
NM_001199570.2	NP_001186499.1	CAP-Gly domain-containing linker protein 3
NM_015526.3	NP_056341.1	CAP-Gly domain-containing linker protein 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ganglioside binding	IDA IDA: Inferred from direct assay	20052288	GOA
enables microtubule binding	IDA IDA: Inferred from direct assay	15262990	GOA
enables microtubule binding	IMP IMP: Inferred from mutant phenotype	20052288	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	26198635	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in membrane biogenesis	IMP IMP: Inferred from mutant phenotype	11854307	GOA
involved in negative regulation of microtubule polymerization	IMP IMP: Inferred from mutant phenotype	15262990	GOA
involved in peptidyl-L-cysteine S-palmitoylation	IMP IMP: Inferred from mutant phenotype	15262990	GOA
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	20052288	GOA
involved in positive regulation of endocytosis	IMP IMP: Inferred from mutant phenotype	11854307	GOA
involved in protein transport along microtubule	IMP IMP: Inferred from mutant phenotype	20052288	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in early endosome membrane	IDA IDA: Inferred from direct assay	11854307	GOA
located in membrane raft	IDA IDA: Inferred from direct assay	15262990	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	19139280	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	15262990	GOA
located in recycling endosome membrane	IDA IDA: Inferred from direct assay	11854307	GOA
located in trans-Golgi network membrane	IDA IDA: Inferred from direct assay	11854307	GOA
located in trans-Golgi network membrane	IMP IMP: Inferred from mutant phenotype	15262990	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLIP3 Protein Structure

Ank_2

CAP_GLY

0
100
200
300
400
500
547 a.a.

Protein Preferred Names	Protein Names
CAP-Gly domain-containing linker protein 3	CLIP-170-related 59 kDa protein

CLIP3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CLIP3	Q96DZ5	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	CLIP3	Q96DZ5	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	CLIP3	Q96DZ5	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	CLIP3	Q96DZ5	CEP83	Homo sapiens	Q9Y592-2	Validated Y2H	32296183
Intra	CLIP3	Q96DZ5	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	CLIP3	Q96DZ5	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	CLIP3	Q96DZ5	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	CLIP3	Q96DZ5	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	CLIP3	Q96DZ5	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	CLIP3	Q96DZ5	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	CLIP3	Q96DZ5	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	CLIP3	Q96DZ5	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02812	CLIP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CLIP3	VGNC	VGNC:97383
Mus musculus	CLIP3	MGD	MGI:1923936
Macaca mulatta	CLIP3	VGNC	VGNC:109601
Bos taurus	CLIP3	VGNC	VGNC:27446
Rattus norvegicus	CLIP3	RGD	RGD:1306245
Canis familiaris	CLIP3	VGNC	VGNC:39344
Others	CLIP3	NCBI