Map2k2 - mitogen-activated protein kinase kinase 2 Gene

Also Known as MK2; MEK2; Prkmk2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 26396

About Map2k2

Chromosome 10: 80,941,749-80,969,809 forward strand.GRCm39:CM001003.3

This gene has 9 transcripts (splice variants), 273 orthologues, 8 paralogues and is associated with 8 phenotypes. Ubiquitous expression in duodenum adult (RPKM 23.), adrenal adult (RPKM 218.2) and 28 other tissues.

Summary

Enables molecular adaptor activity. Involved in positive regulation of cell motility. Acts upstream of or within several processes, including ERK1 and ERK2 cascade; animal organ development; and regulation of neuron projection development. Located in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in cardiofaciocutaneous syndrome 4 and small intestine adenocarcinoma. Orthologous to human MAP2K2 (mitogen-activated protein kinase kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Map2k2 Products (3)

mRNA Protein Name
NM_001347144.1 NP_001334073.1 dual specificity mitogen-activated protein kinase kinase 2 isoform 2
NM_023138.5 NP_075627.2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1
NM_001358539.1 NP_001345468.1 dual specificity mitogen-activated protein kinase kinase 2 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables MAP kinase kinase activity IDA
IDA: Inferred from direct assay
8297798 MGI
enables molecular adaptor activity IDA
IDA: Inferred from direct assay
20179103 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17380122 MGI
Biological Process GO Annotation Evidence References Source
involved in ERBB2-ERBB3 signaling pathway IDA
IDA: Inferred from direct assay
24493648 MGI
acts upstream of or within ERK1 and ERK2 cascade IGI
IGI: Inferred from genetic interaction
25100655 MGI
involved in MAPK cascade IGI
IGI: Inferred from genetic interaction
21220101 MGI
involved in Schwann cell development IMP
IMP: Inferred from mutant phenotype
10704452 MGI
acts upstream of or within epithelial cell proliferation involved in lung morphogenesis IGI
IGI: Inferred from genetic interaction
25100655 MGI
acts upstream of or within face development IGI
IGI: Inferred from genetic interaction
18952847 MGI
acts upstream of or within heart development IGI
IGI: Inferred from genetic interaction
18952847 MGI
involved in insulin-like growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
21699731 MGI
acts upstream of or within lung morphogenesis IGI
IGI: Inferred from genetic interaction
25100655 MGI
involved in myelination IMP
IMP: Inferred from mutant phenotype
10704452 MGI
acts upstream of or within positive regulation of axonogenesis IGI
IGI: Inferred from genetic interaction
24733831 MGI
involved in positive regulation of cell motility IDA
IDA: Inferred from direct assay
20179103 MGI
acts upstream of or within protein phosphorylation IGI
IGI: Inferred from genetic interaction
19047410 MGI
acts upstream of or within regulation of axon regeneration IGI
IGI: Inferred from genetic interaction
24733831 MGI
acts upstream of or within thymus development IGI
IGI: Inferred from genetic interaction
18952847 MGI
acts upstream of or within thyroid gland development IGI
IGI: Inferred from genetic interaction
18952847 MGI
acts upstream of or within trachea formation IGI
IGI: Inferred from genetic interaction
25100655 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
23920377 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Map2k2 Protein Structure

PKc_MEK

PKc_MEK: cd06615 (69 - 386)

  • 0
  • 100
  • 200
  • 300
  • 400 a.a.
Protein Preferred Names Protein Names

dual specificity mitogen-activated protein kinase kinase 2

  • ERK activator kinase 2

  • MAP kinase kinase 2

  • MAP kinase/Erk kinase

  • MAPK/ERK kinase 2

  • MAPKK 2

  • MEK 2

  • protein kinase, mitogen activated, kinase 2, p45

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-E70844 MAP2K2 Recombinant Human Active Protein Kinase / Unkown
HY-RS08036 MAP2K2 Human Pre-designed siRNA Set A / Unkown
HY-RS08037 Map2k2 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08038 Map2k2 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Map2k2 NCBI NCBI:5605