2. Gene
  3. Map2k2 - mitogen-activated protein kinase kinase 2 Gene

Map2k2 - mitogen-activated protein kinase kinase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as MK2; MEK2; Prkmk2

Gene ID: 26396 | Gene type: protein coding

About Map2k2

Chromosome 10: 80,941,749-80,969,809 forward strand.GRCm39:CM001003.3

This gene has 9 transcripts (splice variants), 273 orthologues, 8 paralogues and is associated with 8 phenotypes. Ubiquitous expression in duodenum adult (RPKM 23.), adrenal adult (RPKM 218.2) and 28 other tissues.

Summary

Enables molecular adaptor activity. Involved in positive regulation of cell motility. Acts upstream of or within several processes, including ERK1 and ERK2 cascade; animal organ development; and regulation of neuron projection development. Located in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in cardiofaciocutaneous syndrome 4 and small intestine adenocarcinoma. Orthologous to human MAP2K2 (mitogen-activated protein kinase kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Map2k2 Products(3)

mRNA Protein Name
NM_001347144.1 NP_001334073.1 dual specificity mitogen-activated protein kinase kinase 2 isoform 2
NM_023138.5 NP_075627.2 dual specificity mitogen-activated protein kinase kinase 2 isoform 1
NM_001358539.1 NP_001345468.1 dual specificity mitogen-activated protein kinase kinase 2 isoform 3

Map2k2 Protein Structure

PKc_MEK

PKc_MEK: cd06615 (69 - 386)

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Protein Preferred Names Protein Names

dual specificity mitogen-activated protein kinase kinase 2

ERK activator kinase 2

MAP kinase kinase 2

MAP kinase/Erk kinase

MAPK/ERK kinase 2

MAPKK 2

MEK 2

protein kinase, mitogen activated, kinase 2, p45

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08036 MAP2K2 Human Pre-designed siRNA Set A / Unkown
HY-RS08037 Map2k2 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08038 Map2k2 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Map2k2 NCBI NCBI:5605