2. Gene
  3. Map3k7 - mitogen-activated protein kinase kinase kinase 7 Gene

Map3k7 - mitogen-activated protein kinase kinase kinase 7 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Tak1; B430101B05

Gene ID: 26409 | Gene type: protein coding

About Map3k7

Chromosome 4: 31,964,097-32,023,467 forward strand.GRCm39:CM000997.3

This gene has 9 transcripts (splice variants), 208 orthologues, 1 paralogue and is associated with 32 phenotypes. Ubiquitous expression in CNS E11.5 (RPKM 14.7), limb E14.5 (RPKM 14.) and 28 other tissues.

Summary

Enables Enzyme activator activity; protein kinase activity; and receptor tyrosine kinase binding activity. Involved in several processes, including JNK cascade; anoikis; and negative regulation of necroptotic process. Acts upstream of or within several processes, including intracellular signal transduction; regulation of signal transduction; and tube morphogenesis. Located in postsynaptic density. Is expressed in several structures, including central nervous system; gut; metanephros; reproductive system; and respiratory system. Used to study Wolff-Parkinson-White syndrome. Human ortholog(s) of this gene implicated in frontometaphyseal dysplasia 2 and prostate Cancer. Orthologous to human MAP3K7 (mitogen-activated protein kinase kinase kinase 7). [provided by Alliance of Genome Resources, Apr 2022]

Map3k7 Products(2)

mRNA Protein Name
NM_172688.3 NP_766276.1 mitogen-activated protein kinase kinase kinase 7 isoform A
NM_009316.1 NP_033342.1 mitogen-activated protein kinase kinase kinase 7 isoform B

Map3k7 Protein Structure

STKc_TAK1

STKc_TAK1: cd14058 (41 - 291)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 579 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase kinase kinase 7

TGF-beta-activated kinase 1

transforming growth factor-beta-activated kinase 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-136848 SM1-71 Inhibitor 96.00% Unkown
HY-RS08062 MAP3K7 Human Pre-designed siRNA Set A / Unkown
HY-RS08063 Map3k7 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08064 MAP3K7 Rat Pre-designed siRNA Set A / Unkown
HY-RS08065 MAP3K7CL Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Map3k7 NCBI NCBI:6885