Map3k7 - mitogen-activated protein kinase kinase kinase 7 Gene

Also Known as Tak1; B430101B05

Species: Mus musculus

Gene Type: protein coding
Gene ID: 26409

About Map3k7

Chromosome 4: 31,964,097-32,023,467 forward strand.GRCm39:CM000997.3

This gene has 9 transcripts (splice variants), 208 orthologues, 1 paralogue and is associated with 32 phenotypes. Ubiquitous expression in CNS E11.5 (RPKM 14.7), limb E14.5 (RPKM 14.) and 28 other tissues.

Summary

Enables enzyme activator activity; protein kinase activity; and receptor tyrosine kinase binding activity. Involved in several processes, including JNK cascade; anoikis; and negative regulation of necroptotic process. Acts upstream of or within several processes, including intracellular signal transduction; regulation of signal transduction; and tube morphogenesis. Located in postsynaptic density. Is expressed in several structures, including central nervous system; gut; metanephros; reproductive system; and respiratory system. Used to study Wolff-Parkinson-White syndrome. Human ortholog(s) of this gene implicated in frontometaphyseal dysplasia 2 and prostate Cancer. Orthologous to human MAP3K7 (mitogen-activated protein kinase kinase kinase 7). [provided by Alliance of Genome Resources, Apr 2022]

Map3k7 Products (2)

mRNA Protein Name
NM_172688.3 NP_766276.1 mitogen-activated protein kinase kinase kinase 7 isoform A
NM_009316.1 NP_033342.1 mitogen-activated protein kinase kinase kinase 7 isoform B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables MAP kinase kinase activity IDA
IDA: Inferred from direct assay
12464436 MGI
enables MAP kinase kinase kinase kinase activity IMP
IMP: Inferred from mutant phenotype
20551513 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12556533 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
18762249 MGI
enables protein serine/threonine kinase activity IMP
IMP: Inferred from mutant phenotype
16260493 MGI
enables receptor tyrosine kinase binding IPI
IPI: Inferred from physical interaction
18762249 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within I-kappaB phosphorylation IGI
IGI: Inferred from genetic interaction
16260493 MGI
involved in JNK cascade IDA
IDA: Inferred from direct assay
29291351 MGI
acts upstream of JNK cascade IGI
IGI: Inferred from genetic interaction
16260493 MGI
acts upstream of or within MAPK cascade IDA
IDA: Inferred from direct assay
12556533 MGI
involved in MAPK cascade IMP
IMP: Inferred from mutant phenotype
20551513 MGI
acts upstream of or within angiogenesis IMP
IMP: Inferred from mutant phenotype
16556914 MGI
involved in anoikis IMP
IMP: Inferred from mutant phenotype
23778976 MGI
acts upstream of apoptotic signaling pathway IGI
IGI: Inferred from genetic interaction
16260493 MGI
acts upstream of apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
16260493 MGI
involved in bone development IMP
IMP: Inferred from mutant phenotype
20551513 MGI
acts upstream of or within negative regulation of apoptotic signaling pathway IGI
IGI: Inferred from genetic interaction
16260493 MGI
acts upstream of or within negative regulation of apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
16260493 MGI
involved in negative regulation of necroptotic process IMP
IMP: Inferred from mutant phenotype
21052097 MGI
involved in negative regulation of reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
21052097 MGI
acts upstream of or within negative regulation of ripoptosome assembly involved in necroptotic process IGI
IGI: Inferred from genetic interaction
21052097 MGI
acts upstream of or within neural tube formation IMP
IMP: Inferred from mutant phenotype
16260493 MGI
involved in osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
20551513 MGI
acts upstream of or within positive regulation of JNK cascade IGI
IGI: Inferred from genetic interaction
16260493 MGI
involved in positive regulation of canonical NF-kappaB signal transduction IGI
IGI: Inferred from genetic interaction
16260493 MGI
involved in positive regulation of macroautophagy IMP
IMP: Inferred from mutant phenotype
23778976 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
12464436 MGI
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
28842570 MGI
acts upstream of or within regulation of reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
21052097 MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
16145668 MGI
Cellular Component GO Annotation Evidence References Source
located in postsynaptic density IDA
IDA: Inferred from direct assay
17114649 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Map3k7 Protein Structure

STKc_TAK1

STKc_TAK1: cd14058 (41 - 291)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 579 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase kinase kinase 7

  • TGF-beta-activated kinase 1

  • transforming growth factor-beta-activated kinase 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-136848 SM1-71 Inhibitor 96.09% Unkown
HY-RS08062 MAP3K7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08063 Map3k7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08064 MAP3K7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08065 MAP3K7CL Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Map3k7 NCBI NCBI:6885