GCNT1 - glucosaminyl (N-acetyl) transferase 1 Gene

Also Known as G6NT; C2GNT; C2GNT1; NACGT2; NAGCT2; C2GNT-L; C2GlcNAcT

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2650

About GCNT1

Cytogenetic location: 9q21.13 Genomic coordinates (GRCh38): 9:76,441,666-76,507,416 (from NCBI)

This gene has 6 transcripts (splice variants), 150 orthologues and 8 paralogues. Biased expression in duodenum (RPKM 20.0), stomach (RPKM 13.9) and 13 other tissues.

Summary

This gene is a member of the beta-1,6-N-acetylglucosaminyltransferase gene family. It is essential to the formation of Gal beta 1-3(GlcNAc beta 1-6)GalNAc structures and the core 2 O-glycan branch. The gene coding this enzyme was originally mapped to 9q21, but was later localized to 9q13. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

GCNT1 Products (9)

mRNA Protein Name
NM_001097633.2 NP_001091102.1 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
NM_001097634.1 NP_001091103.1 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
NM_001097635.2 NP_001091104.1 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
NM_001097636.2 NP_001091105.1 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
NM_001407181.1 NP_001394110.1 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
NM_001407182.1 NP_001394111.1 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
NM_001407183.1 NP_001394112.1 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
NM_001407184.1 NP_001394113.1 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
NM_001490.5 NP_001481.2 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
23027862 GOA
Biological Process GO Annotation Evidence Références Source
involved in O-glycan processing, core 2 IDA
IDA: Inferred from direct assay
1329093 GOA
involved in cell adhesion molecule production IMP
IMP: Inferred from mutant phenotype
23027862 GOA
involved in glycoprotein biosynthetic process IMP
IMP: Inferred from mutant phenotype
23027862 GOA
involved in leukocyte tethering or rolling IMP
IMP: Inferred from mutant phenotype
23027862 GOA
Cellular Component GO Annotation Evidence Références Source
located in Golgi cisterna IDA
IDA: Inferred from direct assay
23027862 GOA
located in trans-Golgi network IDA
IDA: Inferred from direct assay
23027862 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GCNT1 Protein Structure

Branch

Branch: Core-2/I-Branching enzyme (123 - 391)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 428 a.a.
Protein Preferred Names Protein Names

beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

  • beta-1,6-N-acetylglucosaminyltransferase

GCNT1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
GCNT1 Q02742 GOLPH3 Homo sapiens Q9H4A6
Y2H
23027862
Intra
GCNT1 Q02742 GOLPH3 Homo sapiens Q9H4A6
Pull Down
23027862
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS05339 GCNT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus GCNT1 RGD RGD:621370
Canis familiaris GCNT1 VGNC VGNC:54843
Mus musculus GCNT1 MGD MGI:95676
Bos taurus GCNT1 VGNC VGNC:56968
Others GCNT1 NCBI